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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Identification and functional analysis of a locus for improvement of lodging resistance in rice显示文摘 | TAKAYUKI K KEN I | 2004 | Plant physiology2004，134，2： | 1 |
| 3 | A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population显示文摘 | Ken S Hiroshi A Tomohiro K et a l | 2008 | Hypertension2008，52，6： | 1 |
| 4 | Self-induced preparation of assembled shrubbery TiSi nanowires by chemical vapor deposition显示文摘 | DU J KEN Z D TAO K Y | 2008 | Cryst Growth Design2008，8，10： | 1 |
| 5 | Hypothalamic melanocortin signaling and leptin resistance-- Perspective of therapeutic application for obesit~diabetes syn drome显示文摘 | HIROAKI MASUZAKI TT KEN EBIHARA KH NAKAO K | 2009 | Peptides2009，30，： | 1 |
| 6 | Different roles for human lung den- dritic cell subsets in pulmonary immune defense mechanisms 显示文摘 | Ingel K D Ken R B Tania M | 2006 | Am J Respir Cell Mol Biol2006，35，4： | 1 |
| 7 | Desorption kinetic of PCP-contaminated soil:effect of temperature显示文摘 | Ken K C Tse Shang-Lien Lo | 2002 | Water Research2002，36，： | 1 |
| 8 | A unique technique of laser-induced breakdown spectroscopy using transversely excited atmospheric CO2 laser for the sensitive analysis of powder samples 显示文摘 | Ali K Hideaki N Ken F | 2011 | Current Applied Physics2011，11，3： | 1 |
| 9 | Drastic SOxremoval and influences of various factors in O2/CO2pulverized coal combustion system显示文摘 | Hao L Shiro K Ken O | 2001 | Energy&Fuels2001，15，2： | 1 |
| 10 | Software calibration reduces offset and gain errors显示文摘 | Ken K | 2006 | Electronic Engineering Times2006，24，1420： | 1 |
| 11 | Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina 显示文摘 | KUGIYAMA K,YASUE H,KEN O, | 1996 | Circulation1996，94，3： | 1 |
| 12 | Detection of recombinant DNA segments introduced to genetically modified maize (Zea mays)显示文摘 | Takeshi M Hideo K Ken T | | 0，，07： | 1 |
| 13 | Effect of side methyl groups of polymer glycol on elongation - induced crystallization behavior of polyurethane elastomers显示文摘 | KEN K SADAHARU N MUTSUHISA F | 2004 | Pol- ymer2004，45，24： | 1 |
| 14 | Comparison of postoperative volume status and hemodynamics between surgical clipping and endovascular coiling in patients after subarachnoid hemorrhage显示文摘 | Tatsushi M Ken K Yuka Y | 2014 | Journal of Neurosurgical Anesthesiology2014，27，1： | 1 |
| 15 | Ineapability of Teehnology Capability: A Case Study on Produet Innovation in Japanese Facsimile Maehine Industry显示文摘 | Ken K | 1997 | The Journal of Product Innovation Management1997，14，3： | 1 |
| 16 | Influence of hemorrhagic shock on remifentanil: a pharmacokinetic and pharmacodynamic analysis 显示文摘 | Ken BJ Steven K Elizabeth H | 2001 | Anesthesiology2001，94，4： | 1 |
| 17 | Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase:identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant显示文摘 | Tomoko N Ken O Yuko K | 2005 | J Biol Chem2005，280，24： | 1 |
| 18 | SmaB-world overlay P2P networks: construction, management and handling of dynamic flash crowds显示文摘 | Hui Ken Y K Lui John C S Yan David K Y | 2006 | Computer Networks2006，50，15： | 1 |
| 19 | Diagnostic andtherapentic laser conization for cervical intraepithelial neoplasia显示文摘 | MASATSUGU U KEN U MASANORI K | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 20 | Examination of the sputtering profile of NiTi under target heating conditions显示文摘 | Ken K Ho Mohanchandra K P Gregory P Carman | 2002 | Thin Solid Films2002，413，： | 1 |
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