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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | The expanded supraclavicular flap, prefabricated with thoracoacromial vessels, for reconstruction of postburn anterior cervical eontractures 显示文摘 | Alexander M Keren A Michael I | 2007 | Hast Reconstr Surg2007，119，7： | 1 |
| 3 | Acute viral myocarditis :current con- cepts in diagnosis and treatment显示文摘 | Shauer A Gotsman I Keren A | 2013 | Isr Med Assoe J2013，15，3： | 1 |
| 4 | Increased C - reactive protein level after coronary stent in patients with stable coronary artery disease 显示文摘 | Almagor M Keren A Banai S | 2003 | Am Heart J2003，145，2： | 1 |
| 5 | ICD-9 codes for identifyinginfluenza hospitalizations in children显示文摘 | Keren R Wheeler A Coffin SE | 2006 | Emerg Infect Dis2006，12，10： | 1 |
| 6 | Producing electricity from Israeli oil shale with PFBC technology显示文摘 | Grinberg A Keren M Podshivalov V | 2000 | Oil Shale2000，17，4： | 1 |
| 7 | Producing electricity from israel oil shale with PFBC technology显示文摘 | GRINBERG A KEREN M PODSHIVALOV V | 2000 | Oil Shale2000，17，4： | 1 |
| 8 | Antizyme 3 inhibits polyamine uptake and omithine decarboxylase (ODC) activity, but does not stimulate ODC degradation显示文摘 | Snapir Z Keren - Paz A Bercovich Z | 2009 | Biochent J2009，419，1： | 1 |
| 9 | Antiapoptotie function of Bcl-2 in mast ceils is dependent on its association with heat shock protein 90beta 显示文摘 | Cohen Saidon C Carmi I Keren A | 2006 | Blood2006，107，4： | 1 |
| 10 | The impact of sensory preferences and thinking vs feeling appeals on advertising effectiveness 显示文摘 | Golden L L Keren A J | 1983 | Advances in Consumer Research1983，，1： | 1 |
| 11 | The global burden of myocarditis : part 1 : a systematic literature review for the Global Burden of Diseases, Injuries, and Risk Factors 2010 study 显示文摘 | Cooper LT Jr Keren A Sliwa K et at | 2014 | Glob Heart2014，9，1： | 1 |
| 12 | On the psychology of playing blackjack: Normative and descriptive considerations with implications for decision theory显示文摘 | KEREN G WAGERNAAR W A | 1985 | J Experimental Psychol1985，114，： | 1 |
| 13 | Strontium adsorption by noncalcareous soils-exchangeable ions and solution composition effects显示文摘 | Keren R O'Connor G A | 1983 | Soil Science1983，135，： | 1 |
| 14 | Increased C-reactiveprotein level after coronary stent implantation in patients withstable coronary artery disease 显示文摘 | ALMAGOR M KEREN A BANAI S | 2003 | Am Heart J2003，145，2： | 1 |
| 15 | Changes in uric acid levels andallopurinol use in chronic heart failure: association with improved sur-vival显示文摘 | Gotsman I Keren A Lotan C | 2012 | J Card Fail2012，18，9： | 1 |
| 16 | Natural history of left ventricular thrombi:their appearance and resolution in the posthospitalization period of acute myocardial infarction显示文摘 | Keren A Goldberg S Gottlieb S Klein J Schuger C Medina A | 1990 | J Am Coll Cardiol1990，15，： | 1 |
| 17 | Increased C-reactive protein lev-el after coronary stent implantation in patients with stable cor-onary artery disease显示文摘 | Almagor M Keren A Banai S | 2003 | Am Heart J2003，145，2： | 1 |
| 18 | Increased C-reactive protein level after coronary stent implantation in patients with stable conronary artery disease显示文摘 | Almagor M Keren A Banal S | 2003 | Am Heart J2003，145，2： | 1 |
| 19 | Combined effect of salinityand excess boron on plant growth and yield显示文摘 | Yermiyahu U Ben-Gal A Keren R | 2008 | Plant and Soil2008，304，12： | 1 |
| 20 | Hypertrophic cardiomyopathy:the genetic determinants of clinical disease expression显示文摘 | Keren A Syrris P McKenna WJ | 2008 | Nat Clin Pract Cardiovasc Med2008，5，： | 1 |
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