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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | Antizyme 3 inhibits polyamine uptake and omithine decarboxylase (ODC) activity, but does not stimulate ODC degradation显示文摘 | Snapir Z Keren - Paz A Bercovich Z | 2009 | Biochent J2009，419，1： | 1 |
| 3 | Female TBI patients recover better than males显示文摘 | Groswasser Z Cohen M Keren O | 1998 | Brain Inj1998，12，9： | 1 |
| 4 | Role of EGFR as a prog- nostic factor for survival in head and neck cancer:a meta- analysis显示文摘 | Keren S Shoude Z Lu Z | 2014 | Tumour Biol2014，35，3： | 1 |
| 5 | Nonredundant roles for Stat5a/b in directly regulating Foxp3显示文摘 | Yao Z Kanno Y Keren yi M | 2007 | Blood2007，109，10： | 1 |
| 6 | A tunable silk-alginate hydrogel scaffold for stem cell culture and transplantation显示文摘 | Keren Z Harald N Yael B H | 2014 | Biomaterials2014，35，12： | 1 |
| 7 | Benign paroxysmal positional vertigo as the cause of dizziness in patients after severe traumatic brain injury:diagnosis and treatment显示文摘 | MOTIN M KEREN O GROSWASSER Z | 2005 | Brain Inj2005，19，： | 1 |
| 8 | Creep behavior of pure magnesium and Mg-Al alloys in active environments显示文摘 | UNIGOVSKI Y KEREN Z ELIEZER A | 2005 | Mater Sci Eng A2005，398，： | 1 |
| 9 | Effect of dietary concentrations of fat and energy on fat deposition in broilers selected for high or low abdominal adipose tissue显示文摘 | Keren Z S Nitsan Z | 1990 | British Poultry Science1990，31，3： | 1 |
| 10 | Benign Paroxysmal Positional Vertigo as the Cause of Dizziness in Patients after Severe Traumatic Brain Injury: Diagnosis and Treatment显示文摘 | Motin M Keren O Groswasseer Z | 2005 | Brain Inj2005，19，69： | 1 |
| 11 | Noninvasive molecular imaging of small living subjects using Raman spectroscopy显示文摘 | Keren S Zavaleta C Cheng Z | 2008 | Proceedings of the National Academy of Sciences2008，105，15： | 1 |
| 12 | Carbon nano- tubes as photoacoustic molecular imaging agents in living mic'e 显示文摘 | D L Z ADAM Z CRISTINA S KEREN | 2008 | Nature Nanotechnology2008，3，9： | 1 |
| 13 | Effect of different dietary levels of protein of fat deposition in broilers divergently selected for high or low abdominal adipose tissue显示文摘 | Keren Z S Nitsan Z | 1992 | British Poultry Science1992，33，： | 1 |
| 14 | Effect of dietary concentrations of fat and energy on fat deposition in broilers divergently selected for high or low abdominal adipose tissue显示文摘 | Keren Z S Nir I Nitsan Z | 1990 | British Poultry Science1990，31，3： | 1 |
| 15 | Benign paroxysmal positional vertigo as the cause of dizziness in patients after severe traumatic brain injury: diagnosis and treatment显示文摘 | Motin M Keren O Groswasser Z | 2005 | Brain Inj2005，19，9： | 1 |
| 16 | Wastew at er Effects on Montm oril lonit e Suspens ion s andHydraulic Propert ies of S andy Soils显示文摘 | TARCHIT Z J GOLOBAT I Y KEREN R ^ al | 1999 | Soil SciSoc AmJ1999，63，： | 1 |
| 17 | Role of EGFR as a prognostic factor for survival in head and neck cancer: A meta-analysis 显示文摘 | Keren S Shoude Z Lu Z | 2014 | Tumor Biol2014，35，3： | 1 |
| 18 | Mechanism of shape determination in motile cells显示文摘 | Keren K Pincus Z Allen G M | 2008 | Nature2008，453，7194： | 1 |
| 19 | Noninvasive molecular imaging of small living subjects using Raman spectroscopy 显示文摘 | Keren S Zavaleta C Cheng Z | 2008 | Proc Natl Acad Sci USA2008，105，15： | 1 |
| 20 | Role of EGFR as a prognostic factor for survival in head and neck cancer: a meta-analysis显示文摘 | Keren S Shoude Z Lu Z | 2014 | Tumour Biol2014，35，3： | 1 |
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