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| 1 | Lipotoxicity in the liver显示文摘Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21stcentury. With the increasing prevalence of obesity, non-alcoholic fatty liver disease is also emerging as a pandemic. While previously this pathophysiological condition was mainly attributed to triglyceride accumulation in hepatocytes,recent data show that the development of oxidative stress, lipid peroxidation, cell death, inflammation and fibrosis are mostly due to accumulation of fatty acids,and the altered composition of membrane phospholipids. In fact, triglyceride accumulation might play a protective role, and the higher toxicity of saturated or trans fatty acids seems to be the consequence of a blockade in triglyceride synthesis. Increased membrane saturation can profoundly disturb cellular homeostasis by impairing the function of membrane receptors,channels and transporters. However, it also inducesendoplasmic reticulum stress via novel sensing mechanisms of the organelle's stress receptors. The triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. These findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis.This minireview focuses on the metabolic and redox aspects of lipotoxicity and lipoapoptosis, with special regards on the involvement of endoplasmic reticulum stress responses. | Veronika Zámbó Laura Simon-Szabó Péter Szelényi va Kereszturi Gábor Bánhegyi Miklós Csala | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 2 | Safety analysis of reactivity initiated accidents in a HPLWR reactor by the coupled ATHLET-KIKO3D code显示文摘 | MAR(A)CZY C KERESZTURI A TROSZTEL I | | 0，，02： | 1 |
| 3 | The role of external environ- mental factors in changing eruption styles of monogenetic volcanoes in a Mio/Pleistoeene continental volcanic field in western Hungary 显示文摘 | Kereszturi G N6meth K Csillag G | 2011 | Journal of Volcanology & Geothermal Research2011，201，14： | 1 |
| 4 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 5 | Crystallinity of Polyethylene Measured by Density, DSC, and Raman Spectroscopy 显示文摘 | Foldes E Keresztury G Iring M | 2003 | Macromol Mater Eng2003，187，1： | 1 |
| 6 | DNA typing revealing high HLA-Cw polymorphism completes availability of Major Histocompatibility Complex loci in forensic medicine显示文摘 | Keresztury L Rajczy K Tauszik T | 2003 | Am J Forensic Med Pathol2003，24，1： | 1 |
| 7 | Vibrational spectroscopy of triazoles and tetrazole显示文摘 | Billes F Endredi H Keresztury G | 2000 | Journal of Mo- lecular Structure (Theochem)2000，530，： | 1 |
| 8 | 显示文摘 | Kiss A B Keresztury G Fakas L | 1980 | Spectrochim Ac- ta Part A1980，36，： | 1 |
| 9 | No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity显示文摘 | Kereszturi E Kiraly O Barta C | 2006 | BMC Mol Biol2006，24，： | 1 |
| 10 | Vibrational spectroscopy of triazoles and tetrazole显示文摘 | Billes F Endredi H Keresztury G | 2000 | Journal of Molecular Structure (Theochem)2000，530，： | 1 |
| 11 | Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample 显示文摘 | Nagy G Kovacs-Nagy R Kereszturi E | 2009 | BMC Med Genet2009，10，： | 1 |
| 12 | Association of hy- poxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample显示文摘 | Nagy G Kovacs-Nagy R Kereszturi E | 2009 | BMC Med Genet2009，10，： | 1 |
| 13 | The library crisis in New Jersey: a statewide strategy for survival显示文摘 | Keresztury T | 2009 | The Bottom Line Managing Library Fi- nances2009，22，4： | 1 |
| 14 | No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity显示文摘 | Kereszturi E Kiraly O Barta O | 2006 | BMC Mol Biol2006，7，1： | 1 |
| 15 | Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses 显示文摘 | Kereszturi E Kiraly O Csapo Z | 2007 | Am J Med Genet B Neuropsychiatr Genet2007，144，2： | 1 |
| 16 | Surface Modifica- tion of Poly(Tetrafluoroethylene) by Saddle Field Fast Atom Beam Source显示文摘 | Kereszturi K Szab A T th A | 2008 | Surface and Coatings Technology2008，202，24： | 1 |
| 17 | Crystallinity of polyethylene measured by density, DSC and Raman spectroscopy:a comparison显示文摘 | Foldes E Keresztury G Iring M | 2003 | Ange Wandte Makromolekulare Chemie2003，187，1： | 1 |
| 18 | Association of hypoxia inducible factor-1alpha gene polymorphism with both type 1and type 2diabetes in a Caucasian(Hungarian)sample显示文摘 | NAGY G KOVACS-NAGY R KERESZTURI E | 2009 | BMC Med Genet2009，10，： | 1 |
| 19 | A Three-Dimensional Hexagonal benchmark Problem 显示文摘 | Kereszturi A Telbisz M | 1992 | Proceedings of the 2^nd Symposium of AER KFKI Atomic Research Institute Budapest1992，，： | 1 |
| 20 | Development and validation of the three-dimensional dynamic code-KIKO3D 显示文摘 | Kereszturi A | 2003 | Annals of Nuclear Energy2003，30，1： | 1 |
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