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| 1 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 2 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 3 | Correlation of VEGF production with IL - 1α and IL - 6 secretion by human pituitary adenoma cells 显示文摘 | BORG S A KERRY K E ROYDS J A | 2005 | European Journal of Endocrinology2005，152，： | 1 |
| 4 | Changes in the microbiological and physicochemical quality of high-pressure-treated oysters ( Crassostrea gigas ) during chilled storage 显示文摘 | Cruz-Romero M Kerry J Kelly A | 2008 | Food Control2008，19，12： | 1 |
| 5 | Antioxidative mechanisms of teacatechins in chicken meet systems 显示文摘 | Tang S Z Kerry J P’Sheeha D | 2002 | Food chemistry2002，16，： | 1 |
| 6 | Seismic waves in a stratified half - space 显示文摘 | KENNETT B L N KERRY N J | 1979 | Geophys J R Astron Soc1979，57，： | 1 |
| 7 | High pressure processing of shellfish:A review of microbiological and other quality aspects显示文摘 | MURCHIE L W KERRY J P LINTON M | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 8 | Facilitation of conditioned fear exinction by systemic administration or intra-amygdala infusions of D-Cycloserine as assessed with fear-potentiated startle in rats显示文摘 | David L Walker Kerry J Ressler Kwak-Tung LU | 2002 | The Journal of Neuroscience2002，22，6： | 1 |
| 9 | arbon dioxide flavor taint in modified atmosphere packed beef steaks显示文摘 | O'SUHIVAN M G CRUZ-ROMERO M KERRY J P | 2013 | Food Science and Technology2013，44，10： | 1 |
| 10 | Characterization of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | HUGHES M KERRY J ARENDT E | 2002 | Meat Science2002，62，2： | 1 |
| 11 | Ecological-economic analysis of wetlands: scientific integration for management and policy显示文摘 | R Kerry Turner Jeroen C J M van den Bergh Tore Soederqvist | 2000 | Ecological Economics2000，35，： | 1 |
| 12 | Antioxidative effect of dietarytea catechins on lipid oxidation of long - term frozen stored chickenmeat显示文摘 | Tang S Z Kerry J P Sheehan D | 2001 | Meat science2001，57，： | 1 |
| 13 | The importance of the host plant on the interaction of root knot nematodes and the nematophous fungus, Verticillium chlamydosporium Goddard 显示文摘 | Bourne J M Kerry B R Leij de F A A M | 1996 | Biocontrol Science Biology1996，6，： | 1 |
| 14 | Effect of varying the gas headspace to meat ratio on the quality andshelf life of beef steaks packaged in high oxygen modified atmosphere packs 显示文摘 | MURPHY K M O'GRADY M N KERRY J P | 2013 | Meat Science2013，94，4： | 1 |
| 15 | Impact of varying salt and fat levels on the physicochemical properties and sensory quality of white pudding显示文摘 | FELLENDORF S O'SULLIVAN M G KERRY J P | 2015 | Meat science2015，103，： | 1 |
| 16 | Seismic waves in a stratified halfspace 显示文摘 | Kennett B L N Kerry N J | 1979 | Geophys J R Astr Soc1979，57，： | 1 |
| 17 | Influence of processing method and holding time on the physical and sensory qualities of cooked marinated chicken breast fillets 显示文摘 | YUSOP S M O'SULLIVAN M G KERRY J F | 2012 | LWT-Food Science and Technology2012，46，1： | 1 |
| 18 | Effects of high-pressure and heat treatments on physical and biochemicalcharacteristics of oysters (Crassostrea gigas)显示文摘 | Cruz-Romero M Kelly A L Kerry J P | 2007 | InnovativeFood Science and Emerging Technologies2007，，8： | 1 |
| 19 | An improved automated immunochemiluminometric third generation hTSH assay for the ACCESS immunoassay system显示文摘 | Danier J Kerry L Peter G | 1996 | Clin Chem1996，42，： | 1 |
| 20 | Fatty acids, volatile compounds and colour changes in high-pressure-treated oysters ( Crassostrea gigas ) 显示文摘 | CRUZ-ROMERO M C KERRY J P KELLY A L | 2008 | Innovat Food Sci Emerg Tech2008，9，1： | 1 |
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