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| 1 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 4 | De novo expression of intercellular adhesion molecule 1 ( ICAM-1 CD54) in pancreas cancer显示文摘 | Schwaeble W Kerlin M Meyer Zum Büschenfelde KH | | 0，，： | 2 |
| 5 | Activation of Toll - like receptor 4 is associated with insulin resistance in adipocytes显示文摘 | Song M J Kim KH Yoon JM | 2006 | Biochem Biophys Res Commun2006，346，3： | 1 |
| 6 | The robotic,2-stage,3-field esophagolymphadenectomy显示文摘 | Kernstine KH DeArmond DT Karimi M | 2004 | J Thorac Cardiovasc Surg2004，127，6： | 1 |
| 7 | Early and late results of partial left ventriculectomy:single center experience and review of the literature显示文摘 | Ascione R Lim KH Chamberlain M | 2003 | J Card Surg2003，18，3： | 1 |
| 8 | Comparison of MR sequences in quantifying in vitro cartilage degeneration in osteoarthritis of the knee显示文摘 | Uhl M Allmann KH Tauer U | 1998 | The British Journal of Radiology1998，71，3： | 1 |
| 9 | Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction:an experimental serial cardiac magnetic resonance imaging study显示文摘 | Nahrendorf M Hu K Hiller KH | 2002 | J Am Coll Cardiol2002，40，9： | 1 |
| 10 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpineinduced status epileptitus in adult rats 显示文摘 | Chu K Kim M Jung KH | 2004 | Brain Res2004，1023，2： | 1 |
| 11 | Quality criteria for treatment of colorectal cancer:From a surgeon's viewpoint显示文摘 | Link KH Kommann M Bittner R | 2010 | Chirurg2010，81，3： | 1 |
| 12 | Nateglinide improves glycaemic control when added to metformin monotherapy:results of a randomized trial with type 2 diabetes patients显示文摘 | Marre M Van Gaal L Usadel KH | | Diabetes0，，： | 1 |
| 13 | Considerations for implan- tation site of VX2 carcinoma into rabbit liver 显示文摘 | Lee KH Liapi E Buijs M | 2009 | J Vase Interv Radiol2009，20，1： | 1 |
| 14 | In vitro evaluation of polyester-based scaffolds seeded with adipose derived stem cells for peripheral nerve regeneration显示文摘 | Tse KH Sun M Mantovani C | | 0，，： | 1 |
| 15 | Endoscopic papillary dilation(EPD) for the treatment of common bile duct stones and papillary stenosis显示文摘 | Staritz M Ewe K Meyer zum Buschenfelde KH | 1983 | Endoscopy1983，151，： | 1 |
| 16 | Activation of the cardiac ciliary neurotrophie factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity 显示文摘 | Raju SV Zheng M Schuleri KH | 2006 | Proc Natl Acad Sci U S 42006，103，11： | 1 |
| 17 | An epidemic of enterovirus 71 infection in Taiwan显示文摘 | Ho M Chen ER Hsu KH | 1999 | N Engl J Med1999，341，13： | 1 |
| 18 | Synchronous Gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia显示文摘 | Lee KH Williams LM Breakspear M | 2003 | Brain Research Reviews2003，41，1： | 1 |
| 19 | Ecological footprint time series of Austria, the Philippines, and South Korea for 1961-1999: comparing the conventional approach to an Aactual land area' approach显示文摘 | Waekernagel M Monfreda C Erh KH | 2004 | Land Use Policy2004，21，3： | 1 |
| 20 | Randomized clinical trial comparing quality of life after straight and pouch coloanal reconstruction显示文摘 | Sailer M Fuchs KH Fein M | 2002 | Br J Surg2002，89，： | 1 |
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