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| 1 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 2 | Impotence after fractures of the pelvis显示文摘 | King J | 1975 | J Bone Joint Surg Am1975，57，8： | 3 |
| 3 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 4 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 5 | Prednisone,azathioprine,and N-acetylcysteine for pulmonary fibrosis显示文摘 | Raghu G Anstrom K J King TE Jr | | 0，，21： | 2 |
| 6 | Fundamentals and applications of supercritical fluid extraction in chromatographic science 显示文摘 | King J W | 1989 | J Chromatogr Sci1989，27，7： | 2 |
| 7 | Heterogeneity of the genome-linked protein of FMDV显示文摘 | King A M Q Anger T J R Brown F | 1980 | J Virol1980，34，： | 2 |
| 8 | 显示文摘 | Koros P J King T B | 1962 | Trans Metall Soc AIME1962，224，2： | 2 |
| 9 | Glycyl-L-glutamineenriched total parenteral nutrition maintains small intestine gut-associated lymphoid tissue and upper respiratory tract immunity显示文摘 | Li J King BK Janu PG | 1998 | JPEN1998，22，： | 2 |
| 10 | A double-blind, placebocontrolled trial of sertraline for depressive symptoms in patients with stable,chronic schizophrenis 显示文摘 | Mulholland C Lynch G King D J | 2003 | J Psychopharmacol2003，17，： | 1 |
| 11 | phenomena of scintillation noise in radar-tracking system显示文摘 | Dunn J H Howard D D king A M | 1959 | Proceedings of IRE1959，47，5： | 1 |
| 12 | Usefulness of ovarian volume and cysts in female is osexual precocbus puberty 显示文摘 | KING L R SIEGE I M J SOBMON A L | 1993 | J Ultrasound in Medicine1993，12，10： | 1 |
| 13 | Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes显示文摘 | King J Hamil T Creighton J | 2004 | Microvasc Res2004，167，2： | 1 |
| 14 | Surgery, of Rathke cleft cysts: fechical considerations and oulcomcs 显示文摘 | Benveniste R J King WA Walsh J | 2004 | J Neurosurg2004，101，4： | 1 |
| 15 | Intensity-based protein identification by machine learning from a library of tandem mass spectra显示文摘 | Elias J E Gibbons F D King O D | 2004 | Nature Biotechnology2004，22，： | 1 |
| 16 | Supercritical CO2 Extraction of carotene and lutein from leaf protein concentrates显示文摘 | King J w Friedrich J p | 1988 | Journal of Food Science1988，5，53： | 1 |
| 17 | Anthocyanin, phenolic composition, colour measurement and sensory analysis of BC commercial red wines显示文摘 | CLIFF M A KING M C SCHLOSSER J | 2007 | Food Research International2007，40，1： | 1 |
| 18 | Correlation of heavy-truck driver fatigue with vehicle-based control measures显示文摘 | SIEGMUND G P KING D J MUMFORD D K | 1995 | SAE Paper 9525941995，，： | 1 |
| 19 | Prior Political Experience and Gubernatorial Popularity 显示文摘 | King J D Hamman J A Cohen J E | 2005 | Presented at the Fifth Annual State Polities and Policy Conference East Lansing Michigan2005，，： | 1 |
| 20 | Recent developments in acute myelogenous leukemia therapy 显示文摘 | King M E Rowe J M | 2007 | Oncologist2007，12，2： | 1 |
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