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| 1 | Does the root to shoot ratio show a hormetic response to stress? An ecological and environmental perspective显示文摘Root/shoot(R/S)ratio is an important index for assessing plant health,and has received increased attention in the last decades as a sensitive indicator of plant stress induced by chemical or physical agents.The R/S ratio has been discussed in the context of ecological theory and its potential importance in ecological succession,where species follow different strategies for above-ground growth for light or below-ground competition for water and nutrients.We present evidence showing the R/S ratio follows a biphasic dose–response relationship under stress,typical of hormesis.The R/S ratio in response to stress has been widely compared among species and ecological succession classes.It is constrained by a variety of factors such as ontogeny.Furthermore,the current literature lacks dose-response studies incorporating the full dose–response continuum,hence limiting scientific understanding and possible valuable application.The data presented provide an important perspective for new-generation studies that can advance current ecological understanding and improve carbon storage estimates by R/S ratio considerations.Hormetic response of the R/S ratio can have an important role in forestry for producing seedlings with desired characteristics to achieve maximum health/productivity and resilience under plantation conditions. | Evgenios Agathokleous Regina G.Belz Mitsutoshi Kitao Takayoshi Koike Edward J.Calabrese | 2019 | Journal of Forestry Research2019，30，5： | 5 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer显示文摘 | Ryota Nakanishi Jun Harada Munkhbold Tuul Yan Zhao Koji Ando Hiroshi Saeki Eiji Oki Takefumi Ohga Hiroyuki Kitao Yoshihiro Kakeji Yoshihiko Maehara | 2013 | International Journal of Clinical Oncology2013，，6： | 2 |
| 4 | Real-time turbidimetry of LAMP reaction for quantifying template DNA显示文摘 | Yasuyoshi Mori Masataka Kitao Norihiro Tomita Tsugunori Notomi | 2003 | Journal of Biochemical and Biophysical Methods2003，，2： | 2 |
| 5 | Real-time turbidimetry of LAMP reaction for quantifying template DNA显示文摘 | Kitao M Tomita N | 2004 | J Biochem Biophys Methods2004，59，2： | 1 |
| 6 | IgG4-related lung and pleural disease:a clinicopathologic study of 21 cases显示文摘 | Zen Y Inoue D Kitao A | 2009 | Am J Surg Pathol2009，33，： | 1 |
| 7 | Bacterial flora in the digestive tract of prawn, Penaeus japonicus Bate显示文摘 | Yasuda K Kitao T | 1980 | Aquacul- ture1980，19，3： | 1 |
| 8 | Selective syntheses of 2-AIkylamino-and 2-Alkoxy-6,7-dichloro-5,8-dihydmxy-1,4-naphthoquinones显示文摘 | MATSUOKA M HAMANO K KITAO T | | 0，，11： | 1 |
| 9 | To investigate the efficacy and intubation situation of rouronium in pediatric显示文摘 | MC Donald PF Ki jima S Kitao M | 1997 | Anesth Intens Care1997，25，： | 1 |
| 10 | Syntheses and some properties of infrared-absorbing croconium and related dyes显示文摘 | Yasui S Matsuoka M Kitao T | 1988 | Dyes and Pigments1988，10，： | 1 |
| 11 | The uptake trans?porter OATP8 expression decreases during multistep hepato?carcinogenesis: correlation with gadoxetic acid enhanced MR imaging显示文摘 | KITAO A MATSUI 0 YONEDA N | 2011 | Eur Radiol2011，21，10： | 1 |
| 12 | Susceptibility to photo inhibition of three deciduous broadleaf tree species with different successional traits raisedunder various light regimes 显示文摘 | Kitao M Lei T T Koike T | 2000 | Plant Cell and En- viomment2000，23，： | 1 |
| 13 | Urinary Biomarkers for Screening for Renal Scarfing in Children with Febrile Urinary Tract Infection: Pilot Study 显示文摘 | Kitao T Kimata T Yamanouchi S | 2015 | J Urol2015，194，3： | 1 |
| 14 | Investigation of the genetic regulation in allergic rhinitis显示文摘 | SADANAGA Y UNO M KITAO Y | 1990 | Antis Lasus Larynx1990，17，1： | 1 |
| 15 | Leafmorphology and photosynthetic adjustments among deciduous broad-leaved trees within the vertical canopy profile显示文摘 | KOIKE T KITAO M MARUYAMA Y | 2001 | Tree Phvsiology2001，21，1213： | 1 |
| 16 | Hypervascular hepatoce|lular carcinomas showing hyperintensity on hepatobiliary phase of ga doxetic acid-enhanced magnetic resonance imaging: a possible sub type with mature hepatocyte nature显示文摘 | Yoneda N Matsui O Kitao A | 2013 | Jpn J Radiol2013，31，7： | 1 |
| 17 | Decrease in tumor volume and histolohic response to intraarterial neoadjuvant chemotherapy in pateint wich cervical and endometrial ad 显示文摘 | Fujiwaki R Takahashi K Kitao M | 1997 | Gynecol Oncol1997，65，2： | 1 |
| 18 | Tradeoff between shade adaptation and mitigation of photoinhibition in leaves of Quer- cus mongolica and Acer mono acclimated to deep shade显示文摘 | Kitao M Lei TT Koike T | 2006 | Tree Physiology2006，26，4： | 1 |
| 19 | Induction of the bioconversion of leucomycins by glucose and its regulation by butyrate显示文摘 | Kitao C Miyazawa J Omura S | 1979 | Agr Biol Chem1979，43，4： | 1 |
| 20 | Decrease in tumor volume and histologic response to intraarterial neoadjuvant chemotherapy in patients with cervical and endometrial adenocarcinoma显示文摘 | Fujiwaki R Takahashi K Kitao M | 1997 | Gynecol Oncol1997，65，2： | 1 |
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