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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 3 | Fixed-bed pyrolysis of safflower seed:Influence of pyrolysis parameters on product yields and compositions显示文摘 | Beis S H Onay O Kockar O M | 2002 | Renewable Energy2002，26，1： | 1 |
| 4 | Comparison of the genera-tion of oil by the extraction and the hydropyrolysis of biomass显示文摘 | ONAY O GAINES A F KOCKAR M O | 2006 | Fuel2006，85，3： | 1 |
| 5 | Slow,fast,and flash pyrolysis of rapeseed显示文摘 | Onay O Kockar O M | 2003 | Renewable Energy2003，28，15： | 1 |
| 6 | Fast pyrolysis of linseed:product yields and compositions显示文摘 | Aclkgoz C Onay O Kockar O M | 2004 | Journal of Analytical and Applied Pyrolysis2004，71，2： | 1 |
| 7 | Distribution power flow management utilizing an online optimal power flow technique显示文摘 | Dolan M J Davidson E M Kockar I | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 8 | Slow,fast and flash pyrolysis of rapeseed显示文摘 | ONAY O KOCKAR O M | 2003 | Renewable Energy2003，28，15： | 1 |
| 9 | Fixed-bed pyrolysis of safflower seed:Influence of pyrolysis parameters on product yields and compositions显示文摘 | Beis S H Onay O Kockar O M | 2002 | Renewable Energy2002，26，： | 1 |
| 10 | Fixed-bed pyrolysis of safflower seed:influence of pyrolysis parameters on product yields and compositions显示文摘 | BEIS S H ONAY O KOCKAR M | 2002 | Renewable Energy2002，26，： | 1 |
| 11 | Effect of Bentonite on Permeability of Dune Sand显示文摘 | Ameta N K Akgun H Kockar M K | 2008 | EJGE2008，13，： | 1 |
| 12 | Characterization of the pyrolysis oil produced in the slow pyrolysis of sunflower-extracted bagasse显示文摘 | YORGUN S SENSOZ S KOCKAR O M | 2001 | Biomass and Bioenergy2001，20，2： | 1 |
| 13 | Expression of CK-19 and CEA mRNA in peripheral blood of gastric cancer patients 显示文摘 | Kutun S Celik A Cem Kockar M | 2010 | Exp Oncol2010，32，4： | 1 |
| 14 | Fast pyrolysis of rape seed in a well - swept fixed - bed reactor显示文摘 | O Onay S H Beis O M Kockar | 2001 | Journal of Analytical and Applied Pyrolysis2001，5859，： | 1 |
| 15 | Pyrolysis of rapeseed in a free fall reactor for production of bio-oil显示文摘 | Kockar O M | 2006 | Fuel2006，85，7： | 1 |
| 16 | Slow,fast and flash pyrolysis of rapeseed显示文摘 | Kockar O M | 2003 | Renewable Energy2003，28，15： | 1 |
| 17 | Diabetic gastroparesis in as- sociation with autonomic neuropathy and microvasculopathy显示文摘 | Kockar M C Kayaben L K Bavbek N | 2002 | Acta Med Okayama2002，56，5： | 1 |
| 18 | Fixed-bed pyrolysis of rapeseed显示文摘 | Onay O Kockar O M | 2004 | Biomass & Bioenergy2004，26，： | 1 |
| 19 | Distribution power flow management utilizing an online optimal power flow technique显示文摘 | DOLAN M J DAVIDSON E M KOCKAR I | 2012 | IEEE Trans on Power Systems2012，27，2： | 1 |
| 20 | Flash pyrolysis of sunflower oil cake for production of liquid fuels显示文摘 | Yorgun S Sensoz Kockar O S M | 2001 | Journal of Analytical and Applied Pyrolysis2001，60，： | 1 |
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