|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 3 | VDR基因敲除鼠一氧化氮合酶和内皮素-1基因的表达显示文摘目的探讨维生素D受体(VDR)基因敲除鼠血压变化以及与血压水平密切相关的内皮型一氧化氮合酶、内皮素-1基因在主动脉的表达情况,了解维生素D、维生素D受体与血压的联系及可能机制。方法小鼠血压采用动脉血管插管法直接测定,主动脉内皮型一氧化氮合酶、内皮素-1基因表达采用实时定量聚合酶链式反应检测。结果内皮型一氧化氮合酶、内皮素-1基因均能在野生型正常鼠及维生素D受体基因敲除鼠主动脉表达。与野生型正常鼠比较,纯合子维生素D受体基因敲除鼠收缩压、舒张压明显升高,主动脉内皮型一氧化氮合酶基因表达明显下调,内皮素-1基因表达明显上调(P均<0.05),杂合子维生素D受体基因敲除鼠收缩压、舒张压及主动脉内皮型一氧化氮合酶、内皮素-1基因表达则无明显改变(P均>0.05)。相关性研究发现主动脉内皮型一氧化氮合酶基因表达水平与收缩压、舒张压水平呈负相关,与收缩压、舒张压水平呈正相关(P均<0.05)。结论纯合子维生素D受体基因敲除鼠存在与血压密切相关的主动脉内皮型一氧化氮合酶、内皮素-1基因表达水平明显异常。 | 向伟 蒋湘玲 符生苗 Wei Zheng Uskokovic M Jian Kong YC Li | 2005 | 中国热带医学2005，5，5： | 7 |
| 4 | MyShake一个跨界的系统:智能手机用于地震预警显示文摘在城市地区发生的大地震可以造成重大人员伤亡,引发社会和经济灾难。地震预警(Earthquake Early Warning,EEW)可以提供秒到分钟的警报,让人们转移到安全区,使工厂停工,车辆减速和刹车。目前世界上只在少数国家使用传统的地震台网和大地测量观测网运行EEW系统。智能手机比传统地震台网更为广泛和普及,它内置了可检测地震的加速度计。我们开发了一种新的测震系统称为MyShake,它利用智能手机内置传感器来收集数据并分析地震。智能手机MyShake系统可以从日常的各种震动中检测到距手机10km或以内的5级地震。这些数据汇集到观测中心,经过一定的算法处理,可以实时测定地震的位置和震级,发出地震预警信息,证明我们的理念是可行的。对没有地震预警系统的区域,MyShake系统可提供地震预警,而对有预警系统的区域,MyShake系统是对原系统预警能力的补充和增强。此外,该系统地震波形记录可以用来提供快速地震烈度图,以评估地震对建筑物的影响,还可以获取地球内部浅层结构图像和地震破裂过程。 | Qingkai Kong Richard M Allen Louis Schreier Young-Woo Kwon 陈会忠(译) 张晁军(译) 沈萍(译) 李卫东(校) | 2016 | 国际地震动态2016，0，6： | 3 |
| 5 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 6 | Simultaneous measurement of strain and temperature: graphical representation显示文摘Simultaneousmeasurementofstrainandtemperature:graphicalrepresentation⒇WJin(Dept.Electr.Eng.,HongKongPolytechnicUniv.)WCMichie... | W Jin (Dept. Electr. Eng., Hong Kong Polytechnic Univ. ) W C Michie, G Thursby, M Konstantaki, B Culshaw (Optoelectron. Div., Univ. of Strathclyde, Glasgow, UK) | 1997 | 大连理工大学学报1997，37，S2： | 3 |
| 7 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 8 | Variations of bacterioplankton community composition during Microcystis spp. blooms in a shallow eutrophic lake显示文摘 | Xing P Kong FX Cao HS Zhang M Tan X | 2007 | 中国生物学文摘2007，21，8： | 2 |
| 9 | Kinematics and singularity analysis of a novel type of 3 - CRR 3 - DOF translational parallel manipulator 显示文摘 | Kong Xianwen Gosselin C M | 2002 | International Journal of Robotics Research2002，21，9： | 1 |
| 10 | Chemical Vapor Deposition of Methane for Single-Walled Carbon Nanotubes 显示文摘 | Kong Jing Cassell Alan M | 1998 | Chemical Physics Letters1998，292，46： | 1 |
| 11 | Study of the characteristics of CH4 and N2O emission and methods of controlling their emission in the soil-trench wastewater treatment process 显示文摘 | Kong H N Kimochi Y Mizuochi M | 2002 | The Science of the Total Environment2002，290，： | 1 |
| 12 | Facile synthesis of highly ordered mesoporous silver using cubic mesoporous silica template with controlled surface hydrophobicity显示文摘 | Shon J K Kong S S Kim J M | 2009 | Chemical Communications2009，，6： | 1 |
| 13 | H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to duck 显示文摘 | Guan Y Peiris M Kong K F | 2002 | Virol2002，292，： | 1 |
| 14 | Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implica tions for cell based vascular therapy显示文摘 | Griese D P Ehsan A Melo L G Kong D Zhang L Mann M J | 2003 | Circulation2003，108，： | 1 |
| 15 | Functional MR imaging of the spinal cord in cervical spinal cord injury patients by acupuncture at LI 4 (Hegu) and LI 11(Quchi)显示文摘 | CHEN Y X KONG K M WANG W D | 2007 | Conf Proc IEEE Eng Med Biol Soc2007，2007，： | 1 |
| 16 | Silicon quantum-wires arrays synthesized by chemical vapor deposition and its icrostructural properties显示文摘 | LU M LI M K KONG L B | 2003 | Chemical Physics Letters2003，374，： | 1 |
| 17 | Reactive oxygen species:the unavoidable environmental insult? 显示文摘 | Gracy R W Talent J M Kong Y | 1999 | Mutation Research1999，428，12： | 1 |
| 18 | Improved biological performance of Ti implants due to surface modification by micro-arc oxidation显示文摘 | Li L H Kong Y M Kim H W | 2004 | Biomaterials2004，25，： | 1 |
| 19 | A new scaling method for component maps of gas turbine using system identification 显示文摘 | KONG C KI J KANG M | 2003 | Journal of Engineering for Gas Turbines and Power2003，125，： | 1 |
| 20 | Chitosan WN-gamma-pDNA nanoparticle (CIN) therapy for allergic asthma 显示文摘 | Kumar M Kong X Behera A K | 2003 | Genet Vaccines Ther2003，1，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员