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| 1 | Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways显示文摘瞄准:我们显示出从 Benth (吴·竹·尤) 支持的中国植物茱萸 rutaecarpa (法) 的弄干的水果提取的那 rutaecarpine 在胰岛素抵抗的主要骨胳的肌肉房间的葡萄糖消费和反煽动性的 cytokine 表示。在我们调查了 rutaecarpine 是否改善了的这研究,在老鼠的肥胖侧面,类脂化合物反常,葡萄糖新陈代谢和胰岛素抵抗 hyperlipidemia 和 hyperglycemia.Methods 当模特儿:在高脂肪的节食喂 8 个星期的老鼠,由 streptozotocin 的注射列在后面(30 mg/kg, ip ) 导致 hyperlipidemia 和多糖症。在 streptozotocin 注射以后的一个星期,喂脂肪的、对待 streptozotocin 的老鼠口头上地与 rutaecarpine 被对待(25 mg· kg −1·d−1) 或积极控制药 metformin (250 mg·为 7 个星期的 kg −1·d−1) 。身体重量,内脏的脂肪,血类脂化合物侧面和葡萄糖铺平,胰岛素敏感被测量。煽动性的 cytokines 的浆液层次被分析。IRS-1 和 Akt/PKB phosphorylation, PI3K 和 NF-κ在肝纸巾的 B 蛋白质层次被估计;肝和胰的病理学的变化被检验。葡萄糖举起和 AMPK/ACC2 phosphorylation 在有教养的老鼠被学习在 vitro.Results 的骨胳的肌肉房间:rutaecarpine 或 metformin 的管理显著地减少了肥胖,内脏的胖累积,水消费,和浆液 TC, TG 和 LDL 胆固醇在喂脂肪的、对待 streptozotocin 的老鼠铺平。二药也稀释了多糖症并且提高了胰岛素敏感。而且,二药显著地减少了 NF-κ在肝纸巾的 B 蛋白质层次和血浆 TNF-α, IL-6, CRP 和 MCP-1 铺平,并且改善在肝和胰的病理学的变化。另外,二药增加了 PI3K p85 子单元层次和 Akt/PKB phosphorylation,但是减少在肝纸巾的 IRS-1 phosphorylation。有 rutaecarpine 的有教养的骨胳的肌肉房间的治疗(20-180 μ mol/L ) 或 metformin (20 μ mol/L ) 支持了 AMPK 和 ACC2 的 phosphorylation,并且增加了葡萄糖 uptake.Conclusion:Rutaecarpine 改善在经由调整在骨胳的肌肉在肝和 AMPK/ACC2 发信号小径表明小径的 IRS-1/PI3K/Akt 的喂脂肪的、对待 streptozotocin 的老鼠的 hyperlipidemia 和多糖症。 | Xu-qiang NIE Huai-hong CHEN Jian-yong ZHANG Yu-jing ZHANG Jian-wen YANG Hui-jun PAN Wen-xia SONG Ferid MURAD Yu-qi HE Ka BIAN | 2016 | Acta Pharmacologica Sinica2016，37，4： | 23 |
| 2 | Flexible microbubble-based Fabry-Pérot cavity for sensitive ultrasound detection and wide-view photoacoustic imaging显示文摘Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub-blcs routincly act as active microscale oscillators or actuators.In contrast,microbubbles were utilized here as passive reccivers to detect broadband ultrasound waves in aqueous environments.The microbubble was photo-thermally generated on a microstructured optical fiber(MOF)tip,forming a flexible Fabry-Perot cavity whose gas-water interface was sensitive to ultrasound waves.The MOF severed as both a low-loss waveguide and a compact light condenser,allowing high-efficiency generation and stabilization of ultrasmall microbubbles.Integrated with all-fiber interferometry,a 10 um diameter microbubble exhibited a low noise-cquivalcnt pressur elevei of^3.4 mPa/Hz^1/2 and a broad bandwidth of^0.8 MHz,capable of detecting weak ultrasounds emittedfrom red blood cells irradiated by pulsed laser light.With advantages of high sensitivity,compact size,and low cost,the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications. | JUN MA YANG HE XUE BAI LI-PENG SUN KA CHEN KYUNGHWAN OH BAI-OU GUAN | 2020 | Photonics Research2020，8，10： | 4 |
| 3 | Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review显示文摘Dihydroartemisinin(DHA),a first-line antimalarial drug,has demonstrated great anticancer effects in many types of tumors,including liver cancer,glioblastoma,and pancreatic cancer.Due to its abilities to induce programmed cell death(PCD;apoptosis,autophagy and ferroptosis),inhibit tumor metastasis and angiogenesis,and modulate the tumor microenvironment,DHA could become an antineoplastic agent in the foreseeable future.However,the therapeutic efficacy of DHA is compromised owing to its inherent disadvantages,including poor stability,low aqueous solubility,and short plasma halflife.To overcome these drawbacks,nanoscale drug delivery systems(NDDSs),such as polymeric nanoparticles(NPs),liposomes,and metal-organic frameworks(MOFs),have been introduced to maximize the therapeutic efficacy of DHA in either single-drug or multidrug therapy.Based on the beneficial properties of NDDSs,including enhanced stability and solubility of the drug,prolonged circulation time and selective accumulation in tumors,the outcomes of DHA-loaded NDDSs for cancer therapy are significantly improved compared to those of free DHA.This reviewfirst summarizes the current understanding of the anticancer mechanisms of DHA and then provides an overview of DHA-including nanomedicines,aiming to provide inspiration for further application of DHA as an anticancer drug. | Ka Hong Wong Donglin Yang Shanshan Chen Chengwei He Meiwan Chen | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 3 |
| 4 | Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level显示文摘The aorta,with ascending,arch,thoracic and abdominal segments,responds to the heartbeat,senses metabolites and distributes blood to all parts of the body.However,the heterogeneity across aortic segments and how metabolic pathologies change it are not known.Here,a total of 216612 individual cells from the ascending aorta,aortic arch,and thoracic and abdominal segments of mouse aortas under normal conditions or with high blood glucose levels,high dietary salt,or high fat intake were profiled using single-cell RNA sequencing.We generated a compendium of 10 distinct cell types,mainly endothelial(EC),smooth muscle(SMC),stromal and immune cells.The distributions of the different cells and their intercommunication were influenced by the hemodynamic microenvironment across anatomical segments,and the spatial heterogeneity of ECs and SMCs may contribute to differential vascular dilation and constriction that were measured by wire myography.Importantly,the composition of aortic cells,their gene expression profiles and their regulatory intercellular networks broadly changed in response to high fat/salt/glucose conditions.Notably,the abdominal aorta showed the most dramatic changes in cellular composition,particularly involving ECs,fibroblasts and myeloid cells with cardiovascular risk factor-related regulons and gene expression networks.Our study elucidates the nature and range of aortic cell diversity,with implications for the treatment of metabolic pathologies. | Dongxu He Aiqin Mao Chang-Bo Zheng Hao Kan Ka Zhang Zhiming Zhang Lei Feng Xin Ma | 2020 | National Science Review2020，7，5： | 2 |
| 5 | Walking pace and the risk of stroke:A meta-analysis of prospective cohort studies显示文摘Purpose:The extent to which walking pace is associated with a reduced risk for stroke remains unclear.This study examined the association between walking pace and stroke risk based on prospective cohort studies.Methods:Databases of PubMed,EMBASE,Web of Science,Scopus,and China National Knowledge Internet were searched from the inception dates to January 31,2019,for prospective cohort studies focusing on walking pace and risk of stroke in adults.Two reviewers independently extracted data and assessed the quality of the studies.The dependent measure was stroke incidence.Using random-effects models,a metaanalysis was performed to estimate the overall relative risks(RR)of stroke incidence and 95%confidence intervals(CIs)for the individuals with the fastest walking paces vs.individuals with the slowest walking paces.A dose-response relationship was also examined.Results:After screening 1294 titles/abstracts and 14 full-text studies identified in the search,7 studies(from 8 cohorts)were included in the metaanalysis.The 7 studies included a total of 135,645 participants(95.2%women;mean age 63.6 years)and 2229 stroke events(median follow-up time=8.0 years).Compared to individuals in the slowest walking-pace category(median=1.6 km/h),individuals in the fastest walking-pace category(median=5.6 km/h)had a 44%lower risk of stroke(pooled RR=0.56,95%CI:0.48-0.65).There was also a linear dose-response relationship(RR=0.87;95%CI:0.83-0.91),with the risk of stroke decreased by 13%for every 1 km/h increment in baseline walking pace.We observed similar results across walking-pace assessment,type of stroke ascertainment,stroke subtypes,sex,sample size,and duration of follow-up.Conclusion:Findings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke. | Minghui Quan Pengcheng Xun Ru Wang Ka He Peijie Chen | 2020 | Journal of Sport and Health Science2020，9，6： | 2 |
| 6 | Cutting edge:Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4 + but not CD8 + T cells显示文摘 | Newell KA He G Guo Z | 1999 | J Immunol1999，163，： | 1 |
| 7 | Differing Prevalence and Diversity of Bacterial Species in Fetal Membranes from Very Preterm and Term Labor显示文摘 | Jones HE Harris KA Azizia M | 2009 | PLoS One2009，4，12： | 1 |
| 8 | Differentiation benign and malignant breast lasions with T2*-weighted first pass perfusion imaging显示文摘 | Kvistad KA Lundgren S Fjsne HE | 1999 | Acta Radiol1999，40，1： | 1 |
| 9 | Dietary influences on the secretion into and degradation of mucin in the digestive tract of monogastric animals and humans 显示文摘 | Lien KA Sauer WC He JM | 2001 | J Anim Feed Sci2001，10，： | 1 |
| 10 | Differing preva- lence and diversity of bacterial species in fetal membranesfrom very preterm and term labor显示文摘 | Jones HE Harris KA Azizia M | 2009 | PLoS One2009，4，12： | 1 |
| 11 | A new rotational thrombectomy catheter:system design and first clinical experiences显示文摘 | Schmitt HE Jager KA Jacob AL | 1999 | Cardiovesc Intervent Radiol1999，22，： | 1 |
| 12 | Microtubule transport in the axon: Re-thinking a potential role for the actin cytoskele- ton 显示文摘 | Myers KA He Y Hasaka TP | 2006 | Neuroscientist2006，12，2： | 1 |
| 13 | Warm heart surgery显示文摘 | Lichtenstein SV Ashe KA Dalati HE | 1991 | J Thorac Cardiovasc Surg1991，10，2： | 1 |
| 14 | Determinants of CD81dimerization and interaction with hepatitis C virus glycoprotien E2 显示文摘 | Drummer HE Wilson KA Poumbourios P | 2005 | Biochem biophys res Commun2005，328，1： | 1 |
| 15 | Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells显示文摘 | Newell KA He G Guo Z | 1999 | J Immunol1999，163，45： | 1 |
| 16 | Determinants of CD81 dimerization and interaction with hepatitis C virus glycoprotein E2 显示文摘 | Drummer HE Wilson KA Poumbourios P | 2005 | Biochem Biophys Res Commun2005，328，1： | 1 |
| 17 | Sequelae of osteosarcoma medical therapy:a review of rare acute toxicities and late effects显示文摘 | Janeway KA Grier HE | 2010 | Lancet Oncol2010，11，7： | 1 |
| 18 | Warm heart surgery显示文摘 | Lichenstein SV Ashe KA Dalat HE | 1991 | Thorac Cardiovasc Surg1991，101，2： | 1 |
| 19 | The mouse mahogany locus encodes a transmembrane form of human Attractin显示文摘 | Gunn TM Miller KA He L | 1999 | Nature1999，398，6723： | 1 |
| 20 | Postnatal penile length and growth rate correlate to serum testosterone levels: a longitu- dinal study of 1962 normal boys 显示文摘 | Boas M Boisen KA Virtanen HE | 2006 | Eur J Endocrinol2006，154，1： | 1 |
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