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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | Intravenous lidocaineinfusion facilitates acute rehabilitation after laparoscopic colec- tomy显示文摘 | Kaba A Laurent S R Detroz B J | 2007 | Anesthesiology2007，106，1： | 1 |
| 3 | Intravenous lidocaine infusion facilitatesacute rehabilitation after laparoscopic colectomy显示文摘 | KABA A LAURENT S R | 2007 | Anesthesiology2007，106，1： | 1 |
| 4 | The evolution of the doctor-patient relationship显示文摘 | Kaba R Sooriakumaran P | 2007 | Int J Surg2007，5，1： | 1 |
| 5 | Intravenous lidocaine infusion facilitates acute rehabilitation after laporoscopic colectomy显示文摘 | Kaba A Laurent S R Detroz B J | 2007 | Anesthesiology2007，106，1： | 1 |
| 6 | Immediate skin grafting of sub-acute and chronic wounds debrided by hydrosurgery显示文摘 | Vanwijek R Kaba L Boland S | 2010 | J Plast Reeonstr Aesthet Surg2010，63，3： | 1 |
| 7 | The evolution of the doctor - patient relationship显示文摘 | Kaba R Sooriakumaran P | 2007 | International Journal of Surgery2007，，5： | 1 |
| 8 | Severs N J:Altered connexin expression in human congestive heart failure显示文摘 | DUPONT E MATSUSHITA T KABA R A | 2001 | J Mol Cell Cardiol2001，33，2： | 1 |
| 9 | Integration of landscape reclamation and design in mine tailing in Cartagena-La Uni6n, SE Spain显示文摘 | Kabas S Acosta J A Zornoza R | 2011 | International Journal of Energy and Environment2011，5，2： | 1 |
| 10 | Altered connexin expression in human congeative heart failure 显示文摘 | DUPONT E MATSUSHITA T KABA R A | 2001 | J Mol Cell Cardiol2001，33，2： | 1 |
| 11 | Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy显示文摘 | Kaba A Laurent S R Detroz B J | 2007 | Anesthesiology2007，106，1： | 1 |
| 12 | Integration of Landscape Reclamation and Design in a Mine Tailing in Cartagena-La U- nion, Se Spain 显示文摘 | Kabas S Acosta J A Zornoza R | 2011 | International Journal of Energy and Environ- ment2011，2，5： | 1 |
| 13 | Altered connexin expression in human congestive heart failure显示文摘 | DUPONT E MATSUSHITA T KABA R A | 2001 | J Mol Cell Cardiol2001，33，2： | 1 |
| 14 | The evolution of the doctor-patient relationship显示文摘 | Kaba R Sooriakumaran P | 2007 | International Journal of Surgery2007，1，5： | 1 |
| 15 | Intravenous li- docaine infusion facilitates acute rehabilitation after lapa- roscopic colectomy 显示文摘 | Kaba A Laurent S R Detroz B J | 2007 | Anesthesiology2007，106，1： | 1 |
| 16 | Epidemiology of mamma- lian hepatitis E virus infection'显示文摘 | KABA M MOAL V GEROLAMI R | 2013 | Intervirology2013，56，2： | 1 |
| 17 | Immediate skin grafting of sub-acute and chronic wounds debrided by hydrosurgery显示文摘 | Vanwijck R Kaba L Boland S | 2010 | J Plast Reconstr Aesthet Surg2010，63，3： | 1 |
| 18 | Epidemiology of mammalian hepatitis E virus infection 显示文摘 | KABA M MOAL V GEROLAMI R | 2013 | Intervirology2013，56，2： | 1 |
| 19 | Epidemiology ofmammalian hepatitis E virus infection 显示文摘 | Kaba M Moal V Gerolami R | 2013 | Intervirology2013，56，2： | 1 |
| 20 | Altered connexin expression in human congestive heart failure显示文摘 | Dupont E Matsushita T Kaba R A | 2001 | J Mol Cell Cardiol2001，33，2： | 1 |
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