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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Mixed micelles of PEG 2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide:Enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer(NSCLC)cell lines显示文摘 | Gill KK Kaddoumi A Nazzal S | 2012 | European Journal of Pharmaceutical Sciences2012，46，12： | 1 |
| 3 | High - performance liquid chromatography with fluorescence detection for the simultaneous determination of 3,4 - methylenedioxymeth - amphetamine, methamphetamine and their metabolites in human hair using DIB-CI as a label 显示文摘 | Kaddoumi A Kikura - Hanajiri R Nakashima K | 2004 | Biomed Chromatogr2004，18，3： | 1 |
| 4 | Chiral HPLC Determination of dl-Fenfluramine and dl-Norfenfluramine in Biological Fluids Using DIB-C1 as a Label显示文摘 | A Kaddoumi MN Nakashima M Takahashi | 2001 | Anal Sci2001，，： | 1 |
| 5 | High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1 H-imidazole-2-yl) benzoyl chloride as a label 显示文摘 | Kaddoumi A Kubota A Nakashima MN | 2001 | Biomed Chromatogr2001，15，： | 1 |
| 6 | Hair analysis for fenfluramine and norfenfluramine as biomarkers for N - nitrosofenfluramine ingestion显示文摘 | Kaddoumi A Wada M Nakashima NM | 2004 | Forensic Sci Int2004，146，1： | 1 |
| 7 | 查看详情显示文摘 | Khanfar M Hill R Kaddoumi A Kaddoumi A. Sayed K | | 0，，： | 1 |
| 8 | Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid显示文摘 | Kaddoumi A Choi SU Kinman L | 2007 | Drug Metab Dispos2007，35，9： | 1 |
| 9 | In- hibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospi- nal fluid显示文摘 | Kaddoumi A Choi SU Whittington D | 2007 | Drug Metab Dispos2007，35，9： | 1 |
| 10 | Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide:enhanced chemosenstization and antitumor efficacy against non-small cell Jung cancer(NSCLC)cell lines显示文摘 | GILL K K KADDOUMI A NAZZAL S | 2012 | Eur J Pharm Sci2012，46，12： | 1 |
| 11 | Orlistat limits cholesterol intestinal absorption by Niemann-pick C1-like 1 (NPC1L1) inhibition显示文摘 | Saeed Alqahtani Hisham Qosa Brian Primeaux Amal Kaddoumi | 2015 | European Journal of Pharmacology2015，，： | 1 |
| 12 | Overcoming poor aqueous solubility of drugs for oral delivery 显示文摘 | HEIMBACH T FLEISHER D KADDOUMI A | 2007 | Biotechnology : Pharmaceutical Aspects2007，5，： | 1 |
| 13 | Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C 1-1ike 1: in sire rat intestinal perfusion studies显示文摘 | Ahuasal B Sylvester P W Kaddoumi A | 2010 | Drug Metabolism and Disposition2010，38，6： | 1 |
| 14 | High Performance Liquid Chromatography with Fluorescence Detection for the Determination of Phenylpropanolamine in Human Plasma and Rat's Blood and Brain Microdialysates Using DIB-Cl as a Label 显示文摘 | KADDOUMI AMAL MORI TOYOMI NAKASHIMA MIHOKO N | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，34，3： | 1 |
| 15 | Chiral HPLC determination of dl-Fenfluramine and dl-Norfenfluramine in biological fluids using DIB-Cl as a label显示文摘 | Kaddoumi A Nakashima MN Takahashi M | 2001 | Anal Sci2001，，： | 1 |
| 16 | Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats显示文摘 | Kaddoumi A Nakashima MN Maki T | 2003 | Chromatogr B Analyt Technol Biomed Life Sci2003，791，12： | 1 |
| 17 | Mixed micelles of PEG 2000-DSPE and vitamin-E TPGS for concurrent de- livery of paclitaxel and parthenolide: Enhanced chemo- senstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines显示文摘 | Gill KK Kaddoumi A Nazzal S | 2012 | Eur J Pharm Sci2012，46，12： | 1 |
| 18 | Role of ABC Transporte in the Pathogenesis of Alzheimer's Disease 显示文摘 | Abuznait AH Kaddoumi A | 2012 | ACS Chem Neuro sci2012，3，11： | 1 |
| 19 | Determination of methamphetamine and amphetamine in abusers' plasma and hair samples with HPLC -FL显示文摘 | NAKASHIMA K KADDOUMI A ISHIDA Y | 2003 | Biomed Chromatogr2003，17，7： | 1 |
| 20 | Redox-silent tocotrienol esters as breast cancer prolifer- ation and migration inhibitors 显示文摘 | Behery FA Elnagar AY Akl MR Wali VB Abuasal B Kaddoumi A | 2010 | Bioorg Med Chem2010，18，22： | 1 |
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