|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes 显示文摘 | Thol F Kade S Schlarmann C | 2012 | Blood2012，119，15： | 1 |
| 2 | Frequency and prognostic impact of mutations in SRSF2, U2AFI, and ZRSR2 in patients with myelodysplastic syndromes 显示文摘 | Thol F Kade S Schlarmann C | 2012 | Blood2012，119，15： | 1 |
| 3 | Frequency and prognostic impact of mutations in SRSF2, U2AFI, and ZRSR2 in patients with myelodysplastie syndromes 显示文摘 | Thol F Kade S Schlannann C | 2012 | Blood2012，119，15： | 1 |
| 4 | Frequency and prognostic impact of mutations in SRSF2,U2AF1,and ZRSR2 in patients with myelodysplastic syndromes显示文摘 | Thol F Kade S Schlarmann C | 2012 | Blood2012，119，15： | 1 |
| 5 | Frequency and prognostic impact of mutations in SRSF2,U2AF1,and ZRSR2 in patients with myelodysplastic syndromes显示文摘 | Thol F Kade S Schlarmann C | 2012 | Blood2012，119，： | 1 |
| 6 | Antimutagedie potential of the Thai herb, Mucuna coUettii Lace显示文摘 | WICHAI C WAN'DEE S KADE P | 2008 | Journal of Etlmophanuacology2008，115，1： | 1 |
| 7 | Renal resistive index as a marker of vascular damage in cardiovascular diseases显示文摘 | Lubas A Kade G Niemczyk S | | 0，，： | 1 |
| 8 | Frequency and prognostic impact of mutations in SRSF2,U2AF1,and ZRSR2 in patients with myelodysplastic syndromes 显示文摘 | Thol F Kade S Schlarmann C | 2012 | Blood2012，119，15： | 1 |
| 9 | Renal resistive index as a marker of vascular dmnage in cardiovascular diseases 显示文摘 | Lubas A Kade G Niemczyk S | 2014 | Int Urol Nephrol2014，46，2： | 1 |
| 10 | Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish显示文摘Background:We are using genetics to identify genes specifically involved in hearing regeneration.In a large-scale genetic screening,we identified mgat5a,a gene in the N-glycosylation biosynthesis pathway whose activity negatively impacts hair cell regeneration.Methods:We used a combination of mutant analysis in zebrafish and a hair cell regeneration assay to phenotype the loss of Mgat5a activity in zebrafish.We used pharmacological inhibition of N-glycosylation by swansonine.We also used over-expression analysis by mRNA injections to demonstrate how changes in N-glycosylation can alter cell signaling.Results:We found that mgat5a was expressed in multiple tissues during zebrafish embryo development,particularly enriched in neural tissues including the brain,retina,and lateral line neuromasts.An mgat5a insertional mutation and a CRISPR/Cas9-generated truncation mutation both caused an enhancement of hair cell regeneration which could be phenocopied by pharmacological inhibition with swansonine.In addition to hair cell regeneration,inhibition of the N-glycosylation pathway also enhanced the regeneration of lateral line axon and caudal fins.Further analysis showed that N-glycosylation altered the responsiveness of TGF-beta signaling.Conclusions:The findings from this study provide experimental evidence for the involvement of N-glycosylation in tissue regeneration and cell signaling. | Wuhong Pei Sunny C.Huang Lisha Xu Kade Pettie María Laura Ceci Mario Sánchez Miguel L.Allende Shawn M.Burgess | 2016 | Cell Regeneration2016，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员