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| 1 | Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE显示文摘Multiple sclerosis(MS)is a chronic inflammatory disease of the central nervous system(CNS)in which the immune system damages the protective insulation surrounding the nerve fibers that project from neurons.A hallmark of MS and its animal model,experimental autoimmune encephalomyelitis(EAE),is autoimmunity against proteins of the myelin sheath.Most studies in this field have focused on the roles of CD4^(+)T lymphocytes,which form part of the adaptive immune system as both mediators and regulators in disease pathogenesis.Consequently,the treatments for MS often target the inflammatory CD4^(+)T-cell responses.However,many other lymphocyte subsets contribute to the pathophysiology of MS and EAE,and these subsets include CD8^(+)T cells and B cells of the adaptive immune system,lymphocytes of the innate immune system such as natural killer cells,and subsets of innate-like T and B lymphocytes such asγδT cells,natural killer T cells,and mucosal-associated invariant T cells.Several of these lymphocyte subsets can act as mediators of CNS inflammation,whereas others exhibit immunoregulatory functions in disease.Importantly,the efficacy of some MS treatments might be mediated in part by effects on lymphocytes other than CD4^(+)T cells.Here we review the contributions of distinct subsets of lymphocytes on the pathogenesis of MS and EAE,with an emphasis on lymphocytes other than CD4^(+)T cells.A better understanding of the distinct lymphocyte subsets that contribute to the pathophysiology of MS and its experimental models will inform the development of novel therapeutic approaches. | Luc Van Kaer Joshua L.Postoak Chuan Wang Guan Yang Lan Wu | 2019 | Cellular & Molecular Immunology2019，16，6： | 10 |
| 2 | Particle image velocimetry and computational fluid dynamics analysis of fuel ceil manifold 显示文摘 | LEBAEK J ANDREASEN M B ANDRESEN A A BANG M KAER S K | 2010 | Transactions of ASME Jounml of Fuel Cell Science and Technology2010，7，03： | 1 |
| 3 | Natural killer T cells in health and disease 显示文摘 | Wu L Van Kaer L | 2011 | Front Biosci( Sehol Ed)2011，3，： | 1 |
| 4 | Flow and pressure distribution in fuel cell manifolds 显示文摘 | LEBAEK J ANDREASEN M B ANDRESEN A A BANG M KAER S K | 2010 | Transactions of ASME Journal of Fuel Cell Science and Technology2010，7，06： | 1 |
| 5 | Natural killer T cells in multiple sclerosis and its animal model,experimental autoimmune encephalomyelitis显示文摘 | Van Kaer L Wu L Parekh VV | 2015 | Immunology2015，146，1： | 1 |
| 6 | Ischemic preconditioning- induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency 显示文摘 | Cai ZP Shen Z Van Kaer L | 2008 | FASEB J2008，22，12： | 1 |
| 7 | Autoreactive T ceils mediate NK cell degeneration in autoimmune disease显示文摘 | Liu R Van Kaer L La Cava A | 2006 | J Immunol2006，176，9： | 1 |
| 8 | Immunotherapy with ligands of natural killer T cells 显示文摘 | Wilson MT Singh AK Van Kaer L | 2002 | Trends Mol Med2002，8，7： | 1 |
| 9 | Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model 显示文摘 | Yang JQ Wen X Liu H Folayan G Dong X Zhou M Van Kaer L Singh RR | 2007 | Arthritis Rheum2007，56，4： | 1 |
| 10 | Reciprocal regulation between natural killer ceils and autoreactive T cells 显示文摘 | Shi FD Van Kaer L | 2006 | Nat Rev Immunol2006，6，10： | 1 |
| 11 | Numerical modeling of a straw-fired grate boiler 显示文摘 | Kaer S K | 2004 | Fuel2004，83，9： | 1 |
| 12 | Study by means of high-performance liquid chromatography of solutes that decrease theophylline/protein binding in the serum of uremic patients 显示文摘 | De Smet R Vogeleere P Van Kaer J | 1999 | J Chromatogr A1999，847，12： | 1 |
| 13 | Grate-firing of biomass for heat and power production 显示文摘 | YIN C G ROSENDAHL L A KAER S K | 2008 | Progress in Energy and Combustion Science2008，34，6： | 1 |
| 14 | Invariant natural killer T cells: bridging innate and adaptive immunity 显示文摘 | Van Kaer L Parekh VV Wu L | 2011 | Cell Tissue Res2011，343，1： | 1 |
| 15 | Critical contribution of IFN‐γ and NK cells, but not perforin‐mediated cytotoxicity, to anti‐metastatic effect of α‐galactosylceramide显示文摘 | YoshihiroHayakawa KazuyoshiTakeda HideoYagita ShigeruKakuta YoichiroIwakura LucVan Kaer IkuoSaiki KoOkumura | 2001 | Eur. J. Immunol2001，，6： | 1 |
| 16 | Chemistry and radiation in oxy-fuel combustion: A computational fluid dynamics modeling study显示文摘 | Yin C Rosendahl LA Kaer SK | 2011 | Fuel2011，90，： | 1 |
| 17 | Straw combustion on slow-moving grates -- a comparison of model predictions with experimental data 显示文摘 | KAER S K | 2005 | Biornass ~ Bioenergy2005，28，3： | 1 |
| 18 | NKT cells, T lymphocytes with innate effector functions 显示文摘 | Kaer L V | 2007 | Curr Opin Immunol2007，19，3： | 1 |
| 19 | Reciprocal regulation between natural killer cells and autoreactive T cells显示文摘 | Shi FD Luc Van Kaer | 2006 | Nature Rev2006，10，6： | 1 |
| 20 | CD4+CD25+ Tregs and NKT cells: regulators regulating regulators 显示文摘 | LACAVAA van KAER L FU-DONG-SHI | 2006 | Trends Immunol2006，27，7： | 1 |
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