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| 1 | Type 1 diabetes and polyglandular autoimmune syndrome: A review显示文摘Type 1 diabetes(T1D) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1 D as a monoglandular disease and the relation to polyglandular autoimmune syndrome(PAS) have also been wellexplored. The incidence of T1 D has steadily increased in most parts of the world, especially in industrialized nations. T1 D is frequently associated with autoimmune endocrine and non-endocrine diseases and patients with T1 D are at a higher risk for developing several glandular autoimmune diseases. Familial clustering is observed, which suggests that there is a genetic predisposition. Various hypotheses pertaining to viral- and bacterialinduced pancreatic autoimmunity have been proposed, however a definitive delineation of the autoimmune pathomechanism is still lacking. In patients with PAS, pancreatic and endocrine autoantigens either colocalize on one antigen-presenting cell or are expressed on two/various target cells sharing a common amino acid, which facilitates binding to and activation of T cells. The most prevalent PAS phenotype is the adult type 3 variant or PAS type Ⅲ, which encompasses T1 D and autoimmune thyroid disease. This review discusses the findings of recent studies showing noticeable differences in the genetic background and clinical phenotype of T1 D either as an isolated autoimmune endocrinopathy or within the scope of polyglandular autoimmune syndrome. | Martin P Hansen Nina Matheis George J Kahaly | 2015 | World Journal of Diabetes2015，6，1： | 7 |
| 2 | 肥胖的遗传因素显示文摘肥胖在全世界范围内的流行,给个人以及公共卫生健康带来了沉重的负担。肥胖的发生原因各异,特点不同,具有基因多态性,也是治疗不得力的主要原因之一。肥胖的遗传背景也越来越引起人们的重视,过去的少食多动的理论也收到了新的挑战。近期的研究发现,个体间约40%~70%体重指数(BMI,常用于定义和评估肥胖)差异都被归因于遗传因素。之前至少已经发现77个位点与肥胖有关。但更大部分的BMI基因变异仍未探知。 | 曲伸 Adam E.Locke Bratati Kahali Sonja I.Berndt | 2015 | 糖尿病天地(临床)2015，9，3： | 3 |
| 3 | Dimethylammonium iodide stabilized bismuth halide perovskite photocatalyst for hydrogen evolution显示文摘Metal halide perovskites have emerged as novel and promising photocatalysts for hydrogen generation.Currently,their stability in water is a vital and urgent research question.In this paper a novel approach to stabilize a bismuth halide perovskite[(CH_(3))_(2)NH_(2)]_(3)[Bil_(6)](DA_(3)Bil_(6))in water using dimethylammonium iodide(DAI)without the assistance of acids or coatings is reported.The DA3Bil6 powder exhibits good stability in DAI solutions for at least two weeks.The concentration of DAI is found as a critical parameter,where the I^(-)ions play the key role in the stabilization.The stability of DA3Bil6 in water is realized via a surface dissolution-recrystallization process.Stabilized DA3Bil6 demonstrates constant photocatalytic properties for visible light-induced photo-oxidation of I^(-)ions and with PtCI4 as a co-catalyst(Pt-DA_(3)Bil_(6)),photocatalytic H2 evolution with a rate of 5.7μmol·h^(-1)from HI in DAI solution,obtaining an apparent quantum efficiency of 0.83%at 535 nm.This study provides new insights on the stabilization of metal halide perovskites for photocatalysis in aqueous solution. | He Zhao Kalyani Chordiya Petri Leukkunen Alexey Popov Mousumi Upadhyay Kahaly Krisztian Kordas Satu Ojala | 2021 | Nano Research2021，14，4： | 2 |
| 4 | Cardiovascular and atherogenie aspects of subclinical hypot- hyroidism 显示文摘 | Kahaly GJ | 2000 | Thyroid2000，10，8： | 1 |
| 5 | Selenium and the course of mild Graves′ orbitopathy显示文摘 | Marcocci C Kahaly GJ Krassas GE | 2011 | New England J Med2011，364，20： | 1 |
| 6 | Coneurrent autoimmune diseases in patients with autoimmune hepatitis显示文摘 | Teufel A Weinmann A Kahaly G J | 2010 | J Clin Gastroen- terol2010，44，3： | 1 |
| 7 | Genetic studies of body mass indexyield new insights for obesity biology 显示文摘 | Locke AE Kahali B Bemdt SI | 2015 | Nature2015，518，7538： | 1 |
| 8 | Glycosaminoglycan antibodies in endocrine ophthalmopathy显示文摘 | Kahaly G Hansen C E Stover C | 1993 | Horm Metab Res1993，25，3： | 1 |
| 9 | The tale of radioiodine and Graves' orbitopathy显示文摘 | Ponto KA Zang S Kahaly GJ | 2010 | Thyroid2010，20，7： | 1 |
| 10 | Thyroid disorders:its very personal显示文摘 | Tomer Y Sarapura V Kahaly GJ | 2010 | Thyroid2010，20，7： | 1 |
| 11 | Imaging in thyroid-associated orbitopathy显示文摘 | Kahaly GJ | 2001 | Eur J Endocrinol2001，145，2： | 1 |
| 12 | Aortic intramural hemorrhage visualized by transesophageal echocardiography Findings and prognostic implications显示文摘 | Mohr- Kahaly S Erbel R Kearney P | 1994 | J Am Coil Cardioh1994，23，： | 1 |
| 13 | Psychosocial factors in subjects with thyroid associated ophthalmopathy显示文摘 | Kahaly GJ Hardt J Petrak F | | 0，，： | 1 |
| 14 | Thyroid hormone action in the heart显示文摘 | Kahaly GJ Dillmann WH | 2005 | Endocr Rev2005，26，5： | 1 |
| 15 | Thyroid hormone action in the heart 显示文摘 | Kahaly G J Dillmann W H | 2005 | Endocr Rev2005，26，5： | 1 |
| 16 | Decreased suppressor T-lymphoeytes in autoimmune thyroid disease detected by monoclonal antibodies 显示文摘 | Kahaly G Sehuler K Sewell AE | 1982 | Clin Endocrinol Matab1982，54，： | 1 |
| 17 | Cardiovascular and atherogenie aspects of subclinical hypothyroidism 显示文摘 | Kahaly GJ | 2000 | Thyroid2000，10，： | 1 |
| 18 | Virulence charac- teristics and molecular epidemiology of enteroaggregative Escherichia coli isolates from hospitalized diarrheal patients in kolkata, india显示文摘 | Soumen Kahali Bhaswati Sarkar K Rajendren | | J C lin Mierobiol0，42，9： | 1 |
| 19 | Low-versus high-dose radiotherapy for Graves' ophthalmopathy: a randomized,single blind trial显示文摘 | Kahaly GJ Rosier HP Pitz S | 2000 | Clin Endocrinol Metab2000，85，1： | 1 |
| 20 | Thyroid hormone action in the heart显示文摘 | Kahaly GJ Dillmann WH | 2005 | Endocr Rev2005，26，5： | 1 |
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