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| 1 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 2 | 参麦注射液防治晚期非小细胞肺癌化疗不良反应的临床观察(英文)显示文摘Objective: To observe the efficacy of Shenmai injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer (NSCLC). Methods: 45 NSCLC patients with stages IIIb-IV were randomly divided into two groups: the treatment group (treated by chemotherapy combined with Shenmai injection) and the control group (treated by chemotherapy only). The efficacy of the two groups was evaluated after 3 cycles of treatment. Results: There was no significant difference between the two groups in the recent curative effects (P > 0.05), while there were significant differences between them in Karnofsky score and weight (P < 0.05). The treatment group was better than the control group in preventing leucopenia and decreased hemoglobin, and significant differences were found between them (P < 0.05). The incidence of thrombocytopenia, nausea and vomiting, hepatic and renal dysfunction in the treatment group was lower than that in the control group, but no significant differences were found between them (P > 0.05). Conclusion: Shenmai injection would not influence the efficacy of chemotherapy on advanced NSCLC patients, while it could improve the quality of life, increase the body weight of patients, alleviate adverse reactions of chemotherapy as myelosuppression so as to improve the tolerance of organism to chemotherapy. | Yang Cao Yan Li Yuzhen Bi Peng Li Ruishen Chen Yusheng Wu Kaiji Tan | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 6 |
| 3 | Minimal-invasive enhancement of auditory perception by terahertz wave modulation显示文摘Hearing impairment is a common disease affecting a substantial proportion of the global population.Currently,the most effective clinical treatment for patients with sensorineural deafness is to implant an artificial electronic cochlea.However,the improvements to hearing perception are variable and limited among healthy subjects.Moreover,cochlear implants have disadvantages,such as crosstalk derived from the currents that spread into non-target tissue between the electrodes.Here,in this work,we describe terahertz wave modulation,a new and minimally invasive technology that can enhance hearing perception in animals by reversible modulation of currents in cochlear hair cells.Using single-cell electrophysiology,guinea pig audiometry,and molecular dynamics simulations,we show that THM can reversibly increase mechano-electrical transducer currents(~50%higher)and voltage-gated K^(+)currents in cochlear hair cells through collective resonance of–C=O groups.In addition,measurement of auditory brainstem response(ABR)in guinea pigs treated with THM indicated a~10 dB increase in hearing sensitivity.This study thus reports a new method of highly spatially selective hearing enhancement without introducing any exogeneous gene,which has potential applications for treatment of hearing disorders as well as several other areas of neuroscience. | Xiaoxuan Tan Kaijie Wu Shuang Liu Yifang Yuan Chao Chang Wei Xiong | 2022 | Nano Research2022，15，6： | 0 |
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