|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative analysis of de novo transcriptome assembly显示文摘The fast development of next-generation sequencing technology presents a major computational challenge for data processing and analysis.A fast algorithm,de Bruijn graph has been successfully used for genome DNA de novo assembly;nevertheless,its performance for transcriptome assembly is unclear.In this study,we used both simulated and real RNA-Seq data,from either artificial RNA templates or human transcripts,to evaluate five de novo assemblers,ABySS,Mira,Trinity,Velvet and Oases.Of these assemblers,ABySS,Trinity,Velvet and Oases are all based on de Bruijn graph,and Mira uses an overlap graph algorithm.Various numbers of RNA short reads were selected from the External RNA Control Consortium(ERCC) data and human chromosome 22.A number of statistics were then calculated for the resulting contigs from each assembler.Each experiment was repeated multiple times to obtain the mean statistics and standard error estimate.Trinity had relative good performance for both ERCC and human data,but it may not consistently generate full length transcripts.ABySS was the fastest method but its assembly quality was low.Mira gave a good rate for mapping its contigs onto human chromosome 22,but its computational speed is not satisfactory.Our results suggest that transcript assembly remains a challenge problem for bioinformatics society.Therefore,a novel assembler is in need for assembling transcriptome data generated by next generation sequencing technique. | CLARKE Kaitlin YANG Yi MARSH Ronald XIE LingLin ZHANG Ke K. | 2013 | Science China(Life Sciences)2013，56，2： | 3 |
| 2 | Irritable Bowel Syndrome: A Review and Update显示文摘 | Kaitlin Occhipinti James Smith | 2012 | Clinics in Colon and Rectal Surgery2012，，01： | 2 |
| 3 | Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection显示文摘Mesenchymal stem/stromal cells(MSCs)are extensively studied as cell-therapy agents for neurological diseases.Recent studies consider exosomes secreted by MSCs as important mediators for MSCs’neuroprotective functions.Exosomes transfer functional molecules including proteins,lipids,metabolites,DNAs,and coding and non-coding RNAs from MSCs to their target cells.Emerging evidence shows that exosomal microRNAs(miRNAs)play a key role in the neuroprotective properties of these exosomes by targeting several genes and regulating various biological processes.Multiple exosomal miRNAs have been identified to have neuroprotective effects by promoting neurogenesis,neurite remodeling and survival,and neuroplasticity.Thus,exosomal miRNAs have significant therapeutic potential for neurological disorders such as stroke,traumatic brain injury,and neuroinflammatory or neurodegenerative diseases and disorders.This review discusses the neuroprotective effects of selected miRNAs(miR-21,miR-17-92,miR-133,miR-138,miR-124,miR-30,miR146a,and miR-29b)and explores their mechanisms of action and applications for the treatment of various neurological disease and disorders.It also provides an overview of state-of-the-art bioengineering approaches for isolating exosomes,optimizing their yield and manipulating the miRNA content of their cargo to improve their therapeutic potential. | Aida Nasirishargh Priyadarsini Kumar Lalithasri Ramasubramanian Kaitlin Clark Dake Hao Sabrina V Lazar Aijun Wang | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 4 | Sexual assault and posttraumatic stress disorder:Areview of the biological,psychological and sociological factors and treatments显示文摘 | Kaitlin A Chivers-Wilson | 2006 | MJM2006，9，2： | 1 |
| 5 | Water-based magnetic fluids as extractants for synthetic organic compounds显示文摘 | Geoffrey D Moeser Kaitlin A Roach William H Green | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 6 | Effect of evaporation and matrix interferences on the association of simulated ignitable liquid residues to the corresponding liquid standard 显示文摘 | Kaitlin R Prather Victoria L McGuffin Ruth Waddell Smith | 2012 | Forensic Science International2012，222，24： | 1 |
| 7 | Using ecological niche modeling for quantitative biogeographic analysis: a case study of Miocene and Pliocene Equinae in the Great Plains显示文摘 | KAITLIN C M and ALYCIA L | 2009 | Stigall Paleobiology2009，35，12： | 1 |
| 8 | Diabetes pathogenesis and management:the endothelium comes of age显示文摘Endothelium,acting as a barrier,protects tissues against factors that provoke insulin resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers with altered function.Endothelial insulin resistance and vascular dysfunction occur early in the evolution of insulin resistance-related disease,can co-exist with and even contribute to the development of metabolic insulin resistance,and promote vascular complications in those affected.The impact of endothelial insulin resistance and vascular dysfunction varies depending on the blood vessel size and location,resulting in decreased arterial plasticity,increased atherosclerosis and vascular resistance,and decreased tissue perfusion.Women with insulin resistance and diabetes are disproportionately impacted by cardiovascular disease,likely related to differential sex-hormone endothelium effects.Thus,reducing endothelial insulin resistance and improving endothelial function in the conduit arteries may reduce atherosclerotic complications,in the resistance arteries lead to better blood pressure control,and in the microvasculature lead to less microvascular complications and more effective tissue perfusion.Multiple diabetes therapeutic modalities,including medications and exercise training,improve endothelial insulin action and vascular function.This action may delay the onset of type 2 diabetes and/or its complications,making the vascular endothelium an attractive therapeutic target for type 2 diabetes and potentially type 1 diabetes. | Kaitlin M.Love Eugene J.Barrett Steven K.Malin Jane E.B.Reusch Judith G.Regensteiner Zhenqi Liu | 2021 | Journal of Molecular Cell Biology2021，13，7： | 1 |
| 9 | A Note on the Jadad Score as an Efficient Tool for Measuring Trial Quality显示文摘 | Kaitlin E. Palys Vance W. Berger | 2013 | Journal of Gastrointestinal Surgery2013，，6： | 1 |
| 10 | EC330, a small-molecule compound, is a potential novel inhibitor of LIF signaling显示文摘Dear Editor,LIF,a multi-functional cytokine,is frequently overexpressed in many human cancers,including breast,colorectal,and pancreatic cancers(Liu et al.,2013;Li et al.,2014;Yu et al.,2014;Pascual-Garcia et al.,2019;Shi et al.,2019;Wang et al.,2019).LIF overexpression is frequently associated with poor prognosis in human cancers(Liu et al.,2013;Li et al.,2014;Yu et al.,2014).LIF functions through binding to LIF receptor complex composed of LIF receptor(LIF-R)and glycoprotein gp130(Taga and Kishimoto,1997;Heinrich et al.,2003;Watanabe et al.,2006).LIF overexpression induces activation of several oncogenic signaling pathways in a cell/tissue type-specific manner,including STAT3,PI3K/AKT,and mTOR,which in turn promotes proliferation,metastasis,and therapeutic resistance of cancer cells(Liu et al.,2013;Li et al.,2014;Yu et al.,2014;Shi et al.,2019).Recent studies have suggested that LIF is a potential important target for cancer therapy,especially for cancers with LIF overexpression.LIF neutralization antibodies(LIF neu Abs)have been reported to block LIF signaling and largely abolish the promoting effect of LIF on cancer progression(Li et al.,2014;Yue et al.,2016;Shi et al.,2019). | Xuetian Yue Fangnan Wu Jianming Wang Kaitlin Kim Bindu Santhamma Kalarickal VDileep Kam YJZhang Suryavathi Viswanadhapalli Ratna KVadlamudi Gulzar Ahmed Zhaohui Feng Klaus Nickisch Wenwei Hu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 11 | Scald burns in children under 3?years: an analysis of NEISS narratives to inform a scald burn prevention program显示文摘 | Wendy C Shields Eileen M McDonald Kaitlin Pfisterer Andrea C Gielen | 2015 | Injury Prevention2015，，： | 1 |
| 12 | Multistate Outbreak of Fungal Infection Associated with Injection of Methylprednisolone Acetate Solution from a Single Compounding Pharmacy - United States, 2012显示文摘 | Kainer Marion Wiese Andrew D Benedict Kaitlin Braden Chris Brandt Mary Harris Julie Park Benjamin J Guh Alice Jernigan John Schaefer Melissa Weber J Todd Wise Matt Smith Rachel M Nguyen Duc | 2012 | EN2012，，41： | 1 |
| 13 | Implementing a surgical checklist: More than checking a box显示文摘 | Shauna M. Levy Casey E. Senter Russell B. Hawkins Jane Y. Zhao Kaitlin Doody Lillian S. Kao Kevin P. Lally KuoJen Tsao | 2012 | Surgery2012，，： | 1 |
| 14 | The antiviral protein Viperin is a radical SAM enzyme显示文摘 | Kaitlin S Duschene Joan B Broderick | 2010 | FEBS Lett2010，584，6： | 1 |
| 15 | Nature:大规模研究揭示生命所必需的基因显示文摘在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中,来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上,论文标题为“High—throughput discovery of novel developmental phenotypes”。 | Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. | 2016 | 现代生物医学进展2016，16，31： | 1 |
| 16 | Identification of chromosomal locations associated with tail biting and being a victim of tail-biting behaviour in the domestic pig ( Sus scrofa domesticus )显示文摘 | Kaitlin Wilson Ricardo Zanella Carlos Ventura Hanne Lind Johansen Tore Framstad Andrew Janczak Adroaldo J. Zanella Holly Louise Neibergs | 2012 | Journal of Applied Genetics2012，，4： | 1 |
| 17 | Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4显示文摘 | Mary V Reid }BS Kaitlin A | | 0，，07： | 1 |
| 18 | 对鱼翅说“不”(英文)显示文摘China changes its tune on these monsters of the deep人们慢慢意识到,鱼翅汤并不是婚宴酒席上的'面子'和'好意头',而是残忍的杀戮。拒绝鱼翅,我们可以.If you’ve been invited to a formal Chinese banquet or wedding in the past few decades,it’s likely yon were served a bowl of soup.Swimming within that bowl of soup may have been translucent strands: | KAITLIN SOLIMINE | 2013 | The World of Chinese2013，0，1： | 1 |
| 19 | 绿色长城上的缺口(英文)显示文摘Kaitlin Solimine takes a closer look at how authorities are trying to combat the growing problem of desertification in | KAITLIN SOLIMINE | 2013 | The World of Chinese2013，0，4： | 0 |
| 20 | Validity and Reproducibility of the Garmin Vector Power Meter When Compared to the SRM Device显示文摘 | Randolph Hutchison Gibson Klapthor Karlee Edwards Kaitlin Bruneau Gregory Mocko Ardalan Vahidi | 2017 | Journal of Sports Science2017，5，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员