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| 1 | Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus显示文摘Dysregulated B-cell activation plays pivotal roles in systemic lupus erythematosus(SLE),which makes B-cell depletion a potential strategy for SLE treatment.The clinical success of anti-CD19 CAR-T cells in treating B-cell malignancies has attracted the attention of researchers.In this study,we aimed to investigate the feasibility of applying anti-CD19 CAR-T cell therapy to SLE treatment in a mouse disease model.We constructed murine anti-CD19 CARs with either CD28 or 4-1BB as the intracellular costimulatory motif and evaluated the therapeutic function of the corresponding CAR-T cells by infusing them into MRL-lpr mice.Furthermore,anti-CD19 CAR-T cells were transferred to MRL-lpr mice before the onset of disease to determine their role in SLE prevention.According to our observations,compared with antibody treatment,the adoptive transfer of our anti-CD19 CAR-T cells showed a more sustained B-cell-depletion effect in MRL-lpr mice.The transfer of syngeneic anti-CD19 CAR-T cells not only prevented disease pathogenesis before the onset of disease symptoms but also displayed therapeutic benefits at a later stage after disease progression.We also tried to optimize the treatment strategy and found that compared with CAR-T cells with the CD28 costimulatory motif,CAR-T cells with the 4-1BB costimulatory motif showed better therapeutic efficiency without cell enrichment.Taken together,these results show that anti-CD19 CAR-T cell therapy was effective in the prevention and treatment of a murine model of SLE,indicating its potential for clinical use in patients. | Xuexiao Jin Qin Xu Chengfei Pu Kaixiang Zhu Cheng Lu Yu Jiang Lei Xiao Yongmei Han Linrong Lu | 2021 | Cellular & Molecular Immunology2021，18，8： | 12 |
| 2 | Facile synthesis and electrochemical sodium storage of CoS2 micro/nano-structures显示文摘我们报导合成和钴二硫化物的电气化学的钠存储(有各种各样的 micro/nano-structures 的公司 2) 。有 microscale 尺寸的公司 2 也被 nanoparticles 装配(经由一条灵巧的 solvothermal 线路或 nanooctahedrons 的 P 公司 2) 构造了固体(O 公司 2) 和空微观结构(H 公司 2) 由热水的方法制作了。在三形态学之中, H 公司 2 作为钠离子电池(亲族) 的阳极展出最大的分泌物能力和最好的率性能。而且, H 公司 2 交付 690 妈 | Xue Liu Kai Zhang Kaixiang Lei Fujun Li Zhanliang Tao Jun Chen | 2016 | Nano Research2016，9，1： | 8 |
| 3 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 4 | Remaining Useful Life Prediction for a Roller in a Hot Strip Mill Based on Deep Recurrent Neural Networks显示文摘Accurate estimation of the remaining useful life(RUL)and health state for rollers is of great significance to hot rolling production.It can provide decision support for roller management so as to improve the productivity of the hot rolling process.In addition,the RUL prediction for rollers is helpful in transitioning from the current regular maintenance strategy to conditional-based maintenance.Therefore,a new method that can extract coarse-grained and fine-grained features from batch data to predict the RUL of the rollers is proposed in this paper.Firstly,a new deep learning network architecture based on recurrent neural networks that can make full use of the extracted coarsegrained fine-grained features to estimate the heath indicator(HI)is developed,where the HI is able to indicate the health state of the roller.Following that,a state-space model is constructed to describe the HI,and the probabilistic distribution of RUL can be estimated by extrapolating the HI degradation model to a predefined failure threshold.Finally,application to a hot strip mill is given to verify the effectiveness of the proposed methods using data collected from an industrial site,and the relatively low RMSE and MAE values demonstrate its advantages compared with some other popular deep learning methods. | Ruihua Jiao Kaixiang Peng Jie Dong | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，7： | 5 |
| 5 | Synthesis of size-controlled CoMn2O4 quantum dots supported on carbon nanotubes for electrocatalytic oxygen reduction/evolution显示文摘 | Jiajia Shi Kaixiang Lei Weiyi Sun Fujun Li Fangyi Cheng Jun Chen | 2017 | Nano Research2017，10，11： | 3 |
| 6 | A novel entry point for pedicle screw placement in the thoracic spine显示文摘This study was aimed to introduce a novel entry point for pedicle screw fixation in the thoracic spine and compare it with the traditional entry point. A novel entry point was found with the aim of improving accuracy, safety and stability of pedicle screw technique based on anatomical structures of the spine. A total of 76 pieces of normal thoracic CT images at the transverse plane and the thoracic pedicle anatomy of 6 cadaveric specimens were recruited.Transverse pedicle angle(TPA), screw length, screw placement accuracy rate and axial pullout strength of the two different entry point groups were compared. There were significant differences in the TPA, screw length, and the screw placement accuracy rate between the two groups(P<0.05). The maximum axial pullout strength of the novel entry point group was slightly larger than that of the traditional group. However, the difference was not significant(P > 0.05). The novel entry point significantly improved the accuracy, stability and safety of pedicle screw placement.With reference to the advantages above, the new entry point can be used for spinal internal fixations in the thoracic spine. | Zhifeng Sun Kaixiang Yang Hongtao Chen Tao Sui Lei Yang Dawei Ge Jian Tang Xiaojian Cao | 2018 | The Journal of Biomedical Research2018，32，2： | 3 |
| 7 | Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages显示文摘The nucleotide-binding domain,leucine-rich-repeat containing family,pyrin domain-containing 3(NLRP3)inflammasome is essential in inflammation and inflammatory disorders.Phosphorylation at various sites on NLRP3 differentially regulates inflammasome activation.The Ser725 phosphorylation site on NLRP3 is depicted in multiple inflammasome activation scenarios,but the importance and regulation of this site has not been clarified.The present study revealed that the phosphorylation of Ser725 was an essential step for the priming of the NLRP3 inflammasome in macrophages.We also showed that Ser725 was directly phosphorylated by misshapen(Msn)/NIK-related kinase 1(MINK1),depending on the direct interaction between MINK1 and the NLRP3 LRR domain.MINK1 deficiency reduced NLRP3 activation and suppressed inflammatory responses in mouse models of acute sepsis and peritonitis.Reactive oxygen species(ROS)upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.Eliminating ROS suppressed NLRP3 activation and reduced sepsis and peritonitis symptoms in a MINK1-dependent manner.Altogether,our study reveals a direct regulation of the NLRP3 inflammasome by Msn family kinase MINK1 and suggests that modulation of MINK1 activity is a potential intervention strategy for inflammasomerelated diseases. | Kaixiang Zhu Xuexiao Jin Zhexu Chi Sheng Chen Songquan Wu Richard D.Sloan Xuai Lin Dante Neculai Di Wang Hu Hu Linrong Lu | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 8 | H~∞ Theory and its Application to the Position of Rolling Mill Control System显示文摘The controller designed according to classical or modern control theory will not satisfy the performance requirements when the controlled object in industrial field can not be described by exact mathematical model or the disturbance of the controlled system. In order to make the controlled system stable and having good performance, H∞ control theory was put forward to solve this practical problem. Taking the position of a rolling mill as the controlled object, it was rectified by optimal engineering way. Then, three different plans were put forward according to Bang-Bang control, LQ control and H∞ control, respectively. The result of the simulation shows that the controller designed according to H∞ method whose robust performance and ability to restrain colors disturbance is satisfactory. | Jie Dong Chaonan Tong Kaixiang Peng(Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，3： | 1 |
| 9 | Radiological thera py with low enery He Nelaser显示文摘 | WEI XINGCHANG LIU KAIXIANG FENG JUNLIN | 1995 | Chinese Physical Therapy Journal1995，18，2： | 1 |
| 10 | 10<ce:hsp sp='0.25'/>W/90<ce:hsp sp='0.25'/>K single-stage pulse tube cryocoolers显示文摘 | Haizheng Dang Libao Wang Kaixiang Yang | 2012 | Cryogenics (-)2012，，4： | 1 |
| 11 | 10W/90K single-stage coaxial pulse tube cryocoolers 显示文摘 | Haizheng Dang Libao Wang Kaixiang Yang | 2012 | Cryogen- ics2012，52，456： | 1 |
| 12 | Modulate the superficial structure of La_(2)Ce_(2)O_(7) catalyst with anchoring CuO_(x) species for the selective catalytic oxidation of NH_(3)显示文摘Air contamination caused by the ammonia slip phenomenon has gradually captured the researcher’s extensive attention.An effective strategy for controlling fugitive NH_(2)is critical to improving the air quality and living environment.In the present work,CuO_(x)/La_(2)Ce_(2)O_(7)composite as a potential candidate catalyst is synthesized through the electrostatic adsorption method for the selective catalytic oxidation(SCO_(2))of NH_(2)to N.The 5%Cu Ox/La_(2)Ce_(2)O_(7)exhibits the best catalytic activity(T=243℃)and ammonia conversion efficiency.The improvement of performance is mainly attributed to the superficial connection of[Ce-O-Cu],which enhances the capturing ability of ammonia molecule and accelerates the dissociating efficiency of N–H bonding for Nevolution,simultaneously.This work provides a facile method to synthesis pyrochlore-like composite catalyst of NH_(2)-SCO_(2) for solving the problem of ammonia slip pollution in the future. | Xiangchen Kong Zhenguo Li Yuankai Shao Xiaoning Ren Kaixiang Li Hanming Wu Congjie Lv Cheng Lv Shengli Zhu | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 13 | Contribution rate plot for nonlinear quality-related fault diagnosis with application to the hot strip mill proeess显示文摘 | Peng Kaixiang Zhang Kai Li Gang | 2013 | Control Engineering Practice2013，21，4： | 1 |
| 14 | Designing all-solid-state Z-Scheme 2D g-C_3N_4/Bi_2WO_6 for improved photocatalysis and photocatalytic mechanism insight显示文摘Bi_2WO_6 was modified by two-dimensional g-C_3N_4(2D g-C_3N_4)via a hydrothermal method.The structure,morphology,optical and electronic properties were investigated by multiple techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy spectra(XPS),Fourier transform infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Ultravioletvisible diffuse reflection spectroscopy(DRS),photocurrent and electrochemical impedance spectroscopy(EIS),electron spin resonance(ESR),respectively.Rhodamine B(Rh B)was used as the target organic pollutant to research the photocatalytic performance of as-prepared composites.The Bi_2WO_6/2D g-C_3N_4exhibited a remarkable improvement compared with the pure Bi_2WO_6.The enhanced photocatalytic activity was because the photogenerated electrons and holes can quickly separate by Z-Scheme passageway in composites.The photocatalytic mechanism was also researched in detail through ESR analysis. | Mao Mao Shuowei Zhao Zhigang Chen Xiaojie She Jianjian Yi Kaixiang Xia Hui Xu Minqiang He Huaming Li | 2018 | Green Energy & Environment2018，3，3： | 1 |
| 15 | Y-Shaped Circular Aptamer–DNAzyme Conjugates for Highly Efficient in Vivo Gene Silencing显示文摘Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo applications.Herein,we report a circular Y-shaped aptamer–DNAzyme conjugate(cYAD)for highly efficient in vivo gene silencing via RNA cleavage,which can been employed in various disease treatments,including cancer,inflammation,as well as viral infections.Systematic studies revealed that cyclization of the DNA structure could improve the stability of oligonucleotide drugs in vivo.Besides,the bivalent aptamer motifs provided a specific and enhanced tumor cell targeting ability for accumulation and retention of the oligonucleotide drugs at the tumor site.As a proof of concept,a widely applicable Na+-dependent fluorescent sensor,NaA43 DNAzyme,was used to inhibit MET gene expression in mice tumor model tissues,which exhibited highly efficient gene silencing performance in vivo,which confirmed our findings with cYAD.This strategy provides a novel approach for the construction of oligonucleotide drugs for practical therapeutic applications. | Kaixiang Zhang Yanan Li Junjie Liu Xue Yang Yuanhong Xu Jinjin Shi Wei Liu Jinghong Li | 2020 | CCS Chemistry2020，2，6： | 1 |
| 16 | A Hybrid Na//K^(+)-Containing Electrolyte//O_(2) Battery with High Rechargeability and Cycle Stability显示文摘Na-O_(2) and K-O_(2) batteries have attracted extensive attention in recent years.However,the parasitic reactions involving the discharge product of NaO_(2) or K anode with electrolytes and the severe Na or K dendrites plague their rechargeability and cycle stability.Herein,we report a hybrid Na//K^(+)-containing electrolyte//O_(2) battery consisting of a Na anode,1.0 M of potassium trifate in diglyme,and a porous carbon cathode.Upon discharging,KO_(2) is preferentially produced via oxygen reduction in the cathode with Na+stripped from the Na anode,and reversely,the KO_(2) is electrochemically decomposed with Na+plated back onto the anode.Te new reaction pathway can circumvent the parasitic reactions involving instable NaO_(2) and active K anode,and alternatively,the good stability and conductivity of KO_(2) and stable Na stripping/plating in the presence of K^(+) enable the hybrid battery to exhibit an average discharge/charge voltage gap of 0.15 V,high Coulombic efciency of>96%,and superior cycling stability of 120 cycles.Tis will pave a new pathway to promote metal-air batteries. | Zhuo Zhu Xiaomeng Shi Dongdong Zhu Liubin Wang Kaixiang Lei Fujun Li | 2019 | Research2019，，1： | 1 |
| 17 | Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation显示文摘5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells.Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery.MFLs@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of photosensitivity.Meanwhile,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor cells.Our findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA. | Airong Li Chenglin Liang Lihua Xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu Jinjin Shi | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 1 |
| 18 | Dynamic changes in physicochemical property,biogenic amines content and microbial diversity during the fermentation of Sanchuan ham显示文摘Sanchuan ham is appreciated in Yunnan Province,China,for its characteristic flavor and taste,while the microbial community structure and biogenic amines content remain unclear during fermentation processes.In this study,we explored the physicochemical property,biogenic amines concentration and microbial diversity of external and internal Sanchuan ham by high-throughput sequencing during the processing of Sanchuan ham.Results showed that the nitrite remained at a stable level of 0.15 mg/kg which was significantly lower than the national health standard safety level of 20 mg/kg.In addition,compared with fresh hams,the content of total free amino acids in ripe Sanchuan ham has grown 14 folds;sour and bitter were the main tastes of Sanchuan ham.Notably,the concentration of cadaverine was the highest of all biogenic amines during the entire fermentation period.At the bacterial phyla level,Firmicutes and Actinobacteria were the two main phyla,while at the genus level,Staphylococcus was a significant strain throughout the whole fermentation.Moreover,the dry stage has a great impact on the succession change of microbial community structure.Simultaneously,the change trends and composition of bacteria in the interior have slight discrepancies with those of the exterior of Sanchuan ham. | Zhongai Chen Hong Chen Huan Du Cong Chen Kaixiang Lu Qiaoli Xue Yongjin Hu | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 19 | N,O co-doped porous carbon with rich pseudocapacitive groups exhibiting superior energy density in an acidic 2.4 V Li_(2)SO_(4)electrolyte显示文摘Designing a carbon material with a unique composition and surface functional groups for offering high specific capacity in a wide voltage window is of great significance to improve the energy density for the supercapacitor in a cheap and eco-friendly aqueous electrolyte.Herein,we develop an efficient strategy to synthesize a N,O co-doped hierarchically porous carbon(NODPC-1.0)with moderate specific surface area and pore volume as well as rich heteroatoms using a deep eutectic solvent(DES)as an activator.It is found that NODPC-1.0 with a large proportion of pseudocapacitive functional groups(pyrrole-N,pyridineN and carbonyl-quinone)can work stable in an acidic 2 mol/L Li_(2)SO_(4)(pH 2.5)electrolyte,exhibiting specific capacities of 375 and 186 F/g at the current densities of 1.0 and 100 A/g,respectively.Also,the assembled symmetric capacitor using the NODPC-1.0 as the active material and 2 mol/L acidic Li_(2)SO_(4)(pH 2.5)as the electrolyte shows an outstanding energy density of 74.4 Wh/kg at a high power density of 1.44 k W/kg under a broad voltage window(2.4 V).Relevant comparative experiments indicate that H+of the acidic aqueous electrolyte plays a crucial part in enhancement the specific capacity,and the abundant pseudocapacitive functional groups on the surface of the NODPC-1.0 sample play the key role in the improvement of electrochemical cycle stability under a broad voltage window. | Xiao Wang Kaixiang Zou Weijing Wu Yuanfu Deng Guohua Chen | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 20 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
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