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| 1 | Sources, Toxicity and Detection Techniques of Semicarbazide: A Review显示文摘Semicarbazide has become an important pollutant in the environment,but there was no comprehensive literature on its advances.In this review,the source,biotoxicity and detection methods are summarized.Among the sources is the material of chemical reaction,a metabolite of nitrofurazone,food processing(production by azobisformamide and hypochlorite treatment),endogenous substances,etc.Semicarbazide is demonstrated to be accumulative and reproductive toxicity,mutagenicity and genotoxicity,endocrine disruptors,and neurotoxicity.There are still many controversies on the effect of genotoxicity and no clear result on the carcinogenic mechanism.HPLC-MS/MS is the mainstream of the detection methods.Other methods,including HPLC,immunoassay method,biosensor method,electrochemical detection,capillary electrophoresis technique,and spectral techniques mainly,have become less and less in recent years.On all these counts,to reduce the content of semicarbazide in the environment,the key is to control the use of nitrofurazone as the banned drug effectively.Meanwhile the toxicity data should be supplemented to reveal its toxic mechanism. | TIAN Xiuhui LI Huanjun HAN Dianfeng WEN Fenggong LIU Huan LIU Ge PENG Kaixiu GONG Xianghong LIU Xin WANG Weiyun YU Haixia XU Yingjiang | 2021 | Journal of Ocean University of China2021，20，5： | 2 |
| 2 | Dual isotope simultaneous imaging to evaluate the effects of intracoronarybone marrow-derived mesenchymal stem cells on perfusion and metabolism in canineswith acute myocardial infarction显示文摘 | Linjun Hao Jin Hao Wei Fang Chunlei Han Kaixiu Zhang Xuemei Wang | 2015 | Biomedical Reports2015，，： | 1 |
| 3 | Influence of plant coverage and environmental variables on pollen productivities:evidence from northern China显示文摘Pollen productivity is a critical parameter in the interpretation of pollen-vegetation relationships,and in the quantitative reconstructions of past vegetation from fossil pollen records.One-year monitoring records were collected for 143 pollen traps in various parts of northern China,together with modern vegetation data.Absolute Pollen Productivity Estimates(APPE)were calculated for 11 taxa using the ratio of pollen influx to plant coverage at each applicable sampling site,in which the plants of the target taxon were present.Relative Pollen Productivity Estimates(RPPE)were calculated for the 11 taxa(taking Poaceae as the reference taxon)at those sites in which each taxon occurred together with Poaceae.Artemisia and Chenopodiaceae were found to have the highest RPPEs and the largest RPPEs ranges,while Pinus and Quercus also had higher RPPEs than Poaceae;Abies,Betula,Larix,Picea and Cyperaceae had relatively low RPPEs.Variations in RPPE between different areas may be explained by variations in climatic conditions,plant coverage and land use practices which might influence plant growing situation.Marked effect that variations in pollen productivity can have on vegetation reconstructions was demonstrated by applying these distinct RPPEs to reconstructions of Holocene vegetation in the Lake Daihai area(northern China),such as a large range of RPPE produces a large range of plant coverage.Variations in RPPEs within a single taxon,related to vegetation coverage and climatic conditions,therefore need to be considered in future vegetation reconstructions. | Kaixiu Zhang Wen Qin Fang Tian Xianyong Cao Yuecong Li Jule Xiao Wei Ding Ulrike Herzschuh Qinghai Xu | 2020 | Frontiers of Earth Science2020，14，4： | 0 |
| 4 | The correlation between the hemoglobin-to-red cell distribution width ratio and all-cause mortality in patients with malignant tumors and sepsis:A retrospective cohort study using the MIMIC-Ⅳdatabase显示文摘Objective The aim of the study was to investigate the correlation between the hemoglobin-to-red cell distribution width ratio(HRR)and all-cause mortality in patients with malignant tumors and sepsis.Methods All patients who met the inclusion criteria of the Medical Information Mart for Intensive Care(MIMIC)-Ⅳwere selected and divided into four groups according to the quartile range of HRR distribution.Kaplan-Meier(K-M)analysis was used to plot the 28-day survival curve,and the log-rank test was used to compare the prognosis in each HRR group.A Cox proportional hazards regression model was used to evaluate the prognosis of HRR as both a continuous and categorical variable,and a restricted cubic spline was used to study the effect of HRR,as a continuous variable,on the mortality in patients with malignant tumors and sepsis.Interaction and subgroup analyses were performed to evaluate the consistency of correlations.Results A total of 3926 patients were included in the study,including 934 patients in the HRR≤4.97 group,988 patients in the 4.97 | Shu Zhang Shan Xu Rui Liao Kaixiu Qin | 2023 | Oncology and Translational Medicine2023，9，2： | 0 |
| 5 | Chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor for neurotrophic keratopathy显示文摘Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of etiologies.The treatment options for neurotrophic keratopathy are limited.In this study,an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor(CTH-mNGF).Its effectiveness was evaluated in corneal denervation(CD)mice and patients with neurotrophic keratopathy.In the preclinical setting,CTH-mNGF was assessed in a murine corneal denervation model.CTH-mNGF was transparent,thermosensitive,and ensured sustained release of mNGF for over 20 hours on the ocular surface,maintaining the local mNGF concentration around 1300 pg/mL in vivo.Corneal denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice.A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2 or 3 neurotrophic keratopathy.Patients received topical CTH-mNGF twice daily for 8 weeks.Fluorescein sodium images,Schirmer’s test,intraocular pressure,Cochet-Bonnet corneal perception test,and best corrected visual acuity were evaluated.In total,six patients(total of seven eyes)diagnosed with neurotrophic keratopathy were enrolled.After 8 weeks of CTH-mNGF treatment,all participants showed a decreased area of corneal epithelial defect,as stained by fluorescence.Overall,six out of seven eyes had fluorescence staining scores<5.Moreover,best corrected visual acuity,intraocular pressure,Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant improvement.An increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven eyes.This study demonstrates that CTH-mNGF is transparent,thermosensitive,and has sustained-release properties.Its effectiveness in healing corneal epithelial defects in all eyes with neurotrophic keratopathy suggests CTH-mNGF has promising application prospects in the treatment of neurotrophic keratopathy,being convenient and cost effective. | Jie Wu Yulei Huang Hanrui Yu Kaixiu Li Shifeng Zhang Guoqing Qiao Xiao Liu Hongmei Duan Yifei Huang Kwok-Fai So Zhaoyang Yang Xiaoguang Li Liqiang Wang | 2024 | Neural Regeneration Research2024，19，3： | 0 |
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