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| 1 | Surgery for gastric cancer patients of age 85 and older: Multicenter survey显示文摘AIM To investigate the surgical therapies for gastric cancer(GC) patients of age 85 or older in a multicenter survey.METHODS Therapeutic opportunities for elderly GC patients have expanded in conjunction with extended life expectancy. However, the number of cases encountered in a single institution is usually very small and surgical therapies for elderly GC patients have not yet been standardized completely. In the present study, a total of 134 GC patients of age 85 or older who underwent surgery in 9 related facilities were retrospectively investigated. The relationships between surgical therapies and clinicopathological or prognostic features were analyzed.RESULTS Eighty-nine of the patients(66%) presented with a comorbidity, and 26(19% overall) presented with more than two comorbidities. Radical lymphadenectomy was performed in 59 patients(44%), and no patient received pre- or post-operative chemotherapy. Forty of the patients(30%) experienced perioperative complications, but no surgical or perioperative mortality occurred. Laparoscopic surgery was performed in only 12 of the patients(9.0%). Univariate and multivariate analyses of the 113 patients who underwent R0 or R1 resection identified the factors of p T3/4 and limited lymphadenectomy as predictive of worse prognosis(HR = 4.68, P = 0.02 and HR =2.19, P = 0.05, respectively). Non-cancer-specific death was more common in c Stage Ⅰ patients than in c Stage Ⅱ or Ⅲ patients. Limited lymphadenectomy correlated with worse cancer-specific survival(P = 0.01), particularly in c Stage Ⅱ patients(P < 0.01). There were no relationships between limited lymphadenectomy and any comorbidities, except for cerebrovascular disease(P = 0.07). CONCLUSION N o n- c a n c e r- s p e c i f i c d e a t h w a s n o t n e g l i g i b l e, particularly in c Stage Ⅰ, and gastrectomy with radical lymphadenectomy appears to be an effective treatment for cS tage Ⅱ elderly GC patients. | Hirotaka Konishi Daisuke Ichikawa Hiroshi Itoh Kenichiro Fukuda Naoki Kakihara Manabu Takemura Kaori Okugawa Kiyoshi Uchiyama Masashi Nakata Hiroshi Nishi Toshiyuki Kosuga Shuhei Komatsu Kazuma Okamoto Eigo Otsuji | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 2 | Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma显示文摘AIM To retrospectively evaluate the diagnostic performance of free-breathing diffusion-weighted imaging(FB-DWI) with modified imaging parameter settings for detecting hepatocellular carcinomas(HCCs).METHODS Fifty-one patients at risk for HCC were scanned with both FB-DWI and respiratory-triggered DWI with the navigator echo respiratory-triggering technique(RTDWI).Qualitatively,the sharpness of the liver contour,the image noise and the chemical shift artifacts on each DWI with b-values of 1000 s/mm2 were independently evaluated by three radiologists using 4-point scoring.Wecompared the image quality scores of each observer between the two DWI methods,using the Wilcoxon signed-rank test.Quantitatively,we compared the signal-to-noise ratios(SNRs) of the liver parenchyma and lesion-to-nonlesion contrast-to-noise ratios(CNRs) after measuring the signal intensity on each DWI with a b-factor of 1000 s/mm2.The average SNRs and CNRs between the two DWI methods were compared by the paired t-test.The detectability of HCC on each DWI was also analyzed by three radiologists.The detectability provided by the two DWI methods was compared using Mc Nemar's test.RESULTS For all observers,the averaged image quality scores of FB-DWI were:Sharpness of the liver contour [observer(Obs)-1,3.08 ± 0.81;Obs-2,2.98 ± 0.73;Obs-3,3.54 ± 0.75],those of the distortion(Obs-1,2.94 ± 0.50;Obs-2,2.71 ± 0.70;Obs-3,3.27 ± 0.53),and the chemical shift artifacts(Obs-1,3.38 ± 0.60;Obs-2,3.15 ± 1.07;Obs-3,3.21 ± 0.85).The averaged image quality scores of RTDWI were:Sharpness of the liver contour(Obs-1,2.33 ± 0.65;Obs-2,2.37 ± 0.74;Obs-3,2.75 ± 0.81),distortion(Obs-1,2.81 ± 0.56;Obs-2,2.25 ± 0.74;Obs-3,2.96 ± 0.71),and the chemical shift artifacts(Obs-1,2.92 ± 0.59;Obs-2,2.21 ± 0.85;Obs-3,2.77 ± 1.08).All image quality scores of FB-DWI were significantly higher than those of RT-DWI(P < 0.05).The average SNR of the normal liver parenchyma by FB-DWI(11.0 ± 4.8) was not significantly different from that shown by RT-DWI(11.0 ± 5.0);nor were the lesion-to-nonlesion CNRs significantly different(FB-DWI,21.4 ± 17.7;RT-DWI,20.1 ± 15.1).For all three observers,the detectability of FB-DWI(Obs-1,43.6%;Obs-2,53.6%;and Obs-3,45.0%) was significantly higher than that of RT-DWI(Obs-1,29.1%;Obs-2,43.6%;and Obs-3,34.5%)(P < 0.05).CONCLUSION FB-DWI showed better image quality and higher detectability of HCC compared to RT-DWI,without significantly reducing the SNRs of the liver parenchyma and lesionto-nonlesion CNRs. | Yukihisa Takayama Akihiro Nishie Yoshiki Asayama Kousei Ishigami Daisuke Kakihara Yasuhiro Ushijima Nobuhiro Fujita Ken Shirabe Atsushi Takemura Hiroshi Honda | 2017 | World Journal of Hepatology2017，9，14： | 3 |
| 3 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 4 | Effect of genome composition and cytoplasm on petal colour in resynthesized amphidiploids and sesquidiploids derived from crosses between Brassica rapa and Brassica oleracea显示文摘 | Zhang B Lu C M Kakihara F | 2002 | Plant Breeding2002，121，： | 1 |
| 5 | Both acute phase and constitutive serum amyloid A are present in atherosclerotic lesions 显示文摘 | Yamada T Kakihara T Kamishima T | 1996 | Pathol Int1996，46，10： | 1 |
| 6 | Role of p53 gene in apoptosis repair of genotoxic tissue damage in mice 显示文摘 | Kato F Kakihara H Kunugita N | 2002 | J Radiat Res2002，，： | 1 |
| 7 | A stnlctural stainless steel with excellent corrosion resistance in welding: JFFAIORW显示文摘 | Fujita Kenichi Yaginuma Hiroshi Kakihara Setsuo | 2008 | JFE Technical Report2008，12，： | 1 |
| 8 | Acute suppu rative thyroiditis as a rare complication of aggressive chemo therapy in children with acute myelogeneous leukemia显示文摘 | IMAI C KAKIHARA WATANABE A | 2002 | Pe diatr Hematol Oncol2002，，19： | 1 |
| 9 | Inhibitory effects of methanol extracts of herbal medicines on substance P-Induced Itch-Scratch Response显示文摘 | Chihiro Tohda Yumiko Kakihara Katsuko Komatsu | 2000 | Biol pharm Bull2000，23，5： | 1 |
| 10 | Inhibitory effects of methanol extracts of herbal medicines on substance P - induced itch - scratch response显示文摘 | Tohda C Kakihara Y Komatsu K | 2000 | Biol Pharm Bull2000，23，5： | 1 |
| 11 | Extraction and detection of endogenous soybean DNA from fermented foods显示文摘 | Kakihara Y Matsufuji H Chino M | 2006 | Food Control2006，17，： | 1 |
| 12 | Effect of clonazepam treatment on antipsychotic drug - induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment 显示文摘 | Yoshimura R Kakihara S Soya A | 2001 | Psychiatry Clin Neurosei2001，55，5： | 1 |
| 13 | An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell显示文摘 | Gong Y Kakihara Y Krogan N | 2009 | Molecular Systems Biology2009，5，1： | 1 |
| 14 | Expanding the ' Mobility' concept 显示文摘 | Kakihara M Sorensen C | 2001 | ACM SIGGROUP Bulletin2001，22，3： | 1 |
| 15 | Cytochemical study of prolactin-releasing peptide (PrRP) in the rat brain显示文摘 | IIJIMA N KATAOKA Y KAKIHARA K | 1999 | Neuroreport1999，10，8： | 1 |
| 16 | Development of aluminum metal matrix composites (Al-MMC) brake rotor and pad显示文摘 | Hiroaki Nakanishi Kenji Kakihara Akinori Nakayama | 2002 | JSAE Review2002，23，： | 1 |
| 17 | The sixth decision\sregarding perforated duodenal ulcer显示文摘 | Lagoo S Mcmahon R L Kakihara M | 2002 | Jsls Journal of the Society of\sLaparoendoscopic Surgeons2002，6，4： | 1 |
| 18 | Production of amphidiploids between A and C genomic species in Brassica显示文摘 | Hondo H Kakihara F | 2001 | Breeding Research2001，3，： | 1 |
| 19 | Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA,HVA,and MHPG during treatment显示文摘 | Yoshimura R Kakihara S Soya A | 2001 | Psychiatry Clin Neurosci2001，55，5： | 1 |
| 20 | Cyclization characteristics of cyclodextrin glucanotransferase are conferred by the NH2-terminal region of the enzyme显示文摘 | FUJIWARA S KAKIHARA H WOO K B | | Appl Envir Microbiol0，58，： | 1 |
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