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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm显示文摘The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative materials.However,its practical benefits still remain unproven in real-world applications,particularly in polymer science.We demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer chemistry.This discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property measurements.Using a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical polymers.From these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further applications.The synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics. | Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick Junko Morikawa Ryo Yoshida | 2019 | npj Computational Materials2019，，1： | 14 |
| 3 | Fabrication of long-Y123 coated conductors by combination of IBAD and PLD 显示文摘 | Kakimoto K Iijima Y Saitoh T | 2003 | Physica C2003，392，： | 1 |
| 4 | CT and MR1 images of pleomorphic adenoma in major and minor salivary glands显示文摘 | Kakimoto N Gamoh S Tamaki J | 2009 | Eur J Radio2009，，69： | 1 |
| 5 | Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6—a role of NAD(P)H oxidase in β-cells显示文摘 | Hirotaka Tsubouchi Toyoshi Inoguchi Mieko Inuo Maiko Kakimoto Toshiyo Sonta Noriyuki Sonoda Shuji Sasaki Kunihisa Kobayashi Hideki Sumimoto Hajime Nawata | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 6 | Separation of β-lactam Antibiotics by Micellar Electrokinetic Chromatography 显示文摘 | Nishi H Tsumagari N Kakimoto T | 1989 | J Chromatogr1989，477，2： | 1 |
| 7 | 显示文摘 | Guo Yiping Kakimoto K I Ohsato H | 2004 | Solid State Commun2004，129，： | 1 |
| 8 | Polymer-ceramic nanocomposites based on new concepts for embedded capacitor显示文摘 | Kakimoto M A Takahashi A Tsurumi T A | 2006 | Mat Sci Eng B-solid2006，132，12： | 1 |
| 9 | High glucose level and free fatty acid stimulates reactive oxygen speies production through protein knase C-dependent activation of NADP(H)oxidase in culture vascular cells显示文摘 | Inoguchi T Li P Umeda F Yu HY Kakimoto M Imamura M | 2000 | Diabetes2000，49，11： | 1 |
| 10 | A 40-nucleotide repeat polymorphism in the human dopamine transporter gene显示文摘 | Sano A Kondoh K Kakimoto Y | 1993 | Hum genet1993，91，4： | 1 |
| 11 | Global Simulation of Coupled Carbon and Oxygen Transport in a Unidirectional Solidification Furnace for SolarCells显示文摘 | Gao B Nakano S Kakimoto K | 2010 | Journal of the Electrochemical Society2010，157，： | 1 |
| 12 | Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells显示文摘 | H. Y. Yu T. Inoguchi M. Kakimoto N. Nakashima M. Imamura T. Hashimoto F. Umeda H. Nawata | 2001 | Diabetologia2001，，5： | 1 |
| 13 | Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test显示文摘 | Masaki Kakimoto Hiroyuki Uetake Takayuki Osanai Yoshinori Shirota Yoko Takagi Emiko Takeshita Yoichi Toriya Kathleen Danenberg Peter V. Danenberg Kenichi Sugihara | 2004 | Cancer Letters2004，，1： | 1 |
| 14 | Subsynchronous Resonance Damping Controll of Thyristor- Controlled Series Capacitor显示文摘 | Naoto Kakimoto Anan Phongphanphanee | 2003 | IEEE transaction on power delivery2003，818，3： | 1 |
| 15 | Hyperbranched polymers : a promising new class of materials 显示文摘 | Jikei M Kakimoto M A | 2001 | Prog Polym Sci2001，26，8： | 1 |
| 16 | Oxidative stress cau- ses alveolar bone loss in metabolic syndrome model mice with type 2 diabetes显示文摘 | Ohnishi T Bandow K Kakimoto K | 2009 | J Periodontal Res2009，44，1： | 1 |
| 17 | 3D numerical analysis of the influence of material property of a crucible on stress and dislocation in multicrystalline silicon for solar cells显示文摘 | Chen Xuejiang Nakano S Kakimoto K | 2011 | Journal of Crystal Growth2011，318，1： | 1 |
| 18 | Hyperbranched polymers:a promising new class of materials显示文摘 | Jikei M Kakimoto M | 2001 | Prog Polym Sci2001，26，： | 1 |
| 19 | Evaluation of rapid ischemic preconditioning in a rabbit model of spinal cord ischemia显示文摘 | Kakimoto M Kawaguchi M Sakamoto T | 2003 | Anesthesiology2003，99，5： | 1 |
| 20 | The effect of sevoflurane on myogenil motor-evoked potentials induced by single and paired transcranial electrical stimulation of the motor cortex during nitrous oxide/ketamine/fentany anesthesia 显示文摘 | Kawaguchi M Inoue S Kakimoto M | 1998 | J Neurosury Anesth1998，10，3： | 1 |
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