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| 1 | Risk factors for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones显示文摘BACKGROUND Previous studies have revealed that patients with asymptomatic common bile duct(CBD)stones are at a high risk of developing post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP).However,no studies to date have addressed the risk factors for PEP in patients with asymptomatic CBD stones.AIM To examine the risk factors for PEP in patients with asymptomatic CBD stones.METHODS Using medical records of three institutions in Japan for 6 years,we identified a total of 1135 patients with choledocholithiasis including 967 symptomatic patients and 168 asymptomatic patients with native papilla who underwent therapeutic ERCP.We performed univariate and multivariate analyses to examine the risk factors for PEP in the 168 patients with asymptomatic CBD stones.RESULTS The overall incidence rate of PEP in all the patients with during study period was 4.7%(53/1135).Of the 168 patients with asymptomatic CBD stones,24(14.3%)developed PEP.In univariate analysis,precut sphincterotomy(P=0.009)and biliary balloon sphincter dilation(P=0.043)were significant risk factors for PEP.In multivariate analysis,precut sphincterotomy(P=0.002,95%CI:2.2-27.8,odds ratio=7.7),biliary balloon sphincter dilation(P=0.015,95%CI:1.4-17.3,odds ratio=4.9),and trainee endoscopists(P=0.048,95%CI:1.01-8.1,odds ratio=2.9)were significant risk factors for PEP.CONCLUSION ERCP for asymptomatic CBD stones should be performed by experienced endoscopists.When performing precut sphincterotomy or biliary balloon sphincter dilation in patients with asymptomatic CBD stones,the placement of a prophylactic pancreatic stent is strongly recommended to prevent PEP. | Hirokazu Saito Tatsuyuki Kakuma Ikuo Matsushita | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 5 |
| 2 | Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring显示文摘AIM To determine the usefulness of assigning narrow-band imaging(NBI) scores for predicting tumor grade and invasion depth in colorectal tumors.METHODS A total of 161 colorectal lesions were analyzed from138 patients who underwent endoscopic or surgical resection after conventional colonoscopy and magnifying endoscopy with NBI. The relationships between the surface and vascular patterns of the lesions, as visualized with NBI, and the tumor grade and depth of submucosa(SM) invasion were determined histopathologically.Scores were assigned to distinct features of the surface microstructures of tubular and papillary-type lesions.Using a multivariate analysis, a model was developed for predicting the tumor grade and depth of invasion based on NBI-finding scores.RESULTS NBI findings that correlated with a high tumor grade were associated with the 'regular/irregular'(P < 0.0001)surface patterns and the 'avascular area' pattern(P =0.0600). The vascular patterns of 'disrupted vessels'(P = 0.0714) and 'thick vessels'(P = 0.0133) but none of the surface patterns were associated with a depth of invasion of ≥ 1000 μm. In our model, a total NBIfinding score ≥ 1 was indicative of a high tumor grade(sensitivity: 0.97; specificity: 0.24), and a total NBIfinding score ≥ 9(sensitivity: 0.56; specificity: 1.0) was predictive of a SM invasion depth ≥ 1000 μm. Scores less than these cutoff values signified adenomas and a SM invasion depth < 1000 μm, respectively. Associations were also noted between selected NBI findings and tumor tissue architecture and histopathology.CONCLUSION Our multivariate statistical model for predicting tumor grades and invasion depths from NBI-finding scores may help standardize the diagnosis of colorectal lesions and inform therapeutic strategies. | Yasuhiko Maeyama Keiichi Mitsuyama Tetsuhiro Noda Shiuchiro Nagata Tsutomu Nagata Shinichiro Yoshioka Hikaru Yoshida Michita Mukasa Hiroaki Sumie Hiroshi Kawano Jun Akiba Yuko Araki Tatsuyuki Kakuma Osamu Tsuruta Takuji Torimura | 2018 | World Journal of Gastroenterology2018，24，42： | 4 |
| 3 | 完全母乳喂养的最佳期限显示文摘 | Kramer MS Kakuma R 胡晓宇 | 2006 | 生殖与避孕2006，26，4： | 4 |
| 4 | Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4显示文摘BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been increasing.However,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor PS.AIM To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4.METHODS This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic ERCP.As a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were included.One-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS 3-4.RESULTS The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),respectively.In the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate analysis.Therapeutic success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or 4.Nevertheless,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics. | Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 5 | Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study显示文摘瞄准:进行一个双窗帘,控制安慰剂使随机化并且评估 Ganoderma 的摘录的安全和功效的变化剂量的学习易懂嗯(G。易懂嗯) 在有更低的泌尿道症状(LUTS ) 的人。方法:我们注册了男志愿者(≥ 50 年) 与一个国际前列腺症状分数(IPSS;问题 1-7 ) ≥ 5 并且前列腺特定的抗原(PSA ) 价值 <
4 ng/mL。志愿者被使随机化进一些安慰剂(n = 12 ) , G。易懂 0.6 mg 的 um (n = 12 ) , 6 mg (n = 12 ) 或 60 mg (n = 14 ) ,管理从前每日。功效在 IPSS 和山峰尿流动率(Q_( 最大)) 从基线作为一个变化被测量。前列腺体积和残余尿被 ultrasonography 估计,并且包括 PSA 层次,验血在基线并且在处理的结束被测量。结果:全面管理很好被容忍,没有主要不利效果。在在试验性的组之间的变化的大小的统计意义在星期被观察 4 和 8。没有变化被观察关于 Q_( 最大) ,残余尿,前列腺体积或 PSA 铺平。结论:G 的摘录。易懂嗯很好被容忍,在 IPSS 的改进被观察。G 的摘录的推荐剂量。易懂嗯是在有 LUTS 的人的 6 mg。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 6 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 7 | Serum vascular endothelial growth factor as a predictor of response and survival in patients with advanced hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy显示文摘 | Takashi Niizeki Shuji Sumie Takuji Torimura Junichi Kurogi Ryoko Kuromatsu Hideki Iwamoto Hajime Aino Masahito Nakano Atsushi Kawaguchi Tatsuyuki Kakuma Michio Sata | 2012 | Journal of Gastroenterology2012，，6： | 2 |
| 8 | Leptin - induced regulation of fat metabolism and its accumulation 显示文摘 | Kakuma T Sakata T | 2001 | Nippon Yakurigaku Zasshi2001，118，5： | 1 |
| 9 | Improved uncertainty of optical frequency domain rellectometry based length measurement by linearizing the frequency chirping of a laser diode显示文摘 | S Kakuma K Ohmura R Ohba | 2003 | Opt Rev2003，10，4： | 1 |
| 10 | Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia 显示文摘 | WANG ZW ZHOU YT KAKUMA T | 1999 | Proc Natl Acad Sci1999，96，10： | 1 |
| 11 | Effects of leptin,trog-litazone,and dietary fat on stearoyl CoA desoturase显示文摘 | Kakuma T Lee Y Unger RH | 2002 | Biochem Biophys Res Commum2002，297，5： | 1 |
| 12 | A random- ized clinical trial of suspension technique for improving early re- covery of urinary continence after radical retropubic prostatecto- my显示文摘 | NOGUCHI M KAKUMA T SUEKANE S | 2008 | BJUInt2008，102，8： | 1 |
| 13 | Delirium in older emergency department patients discharged home: effect on survival显示文摘 | Kakuma R Fort D Galbaud G | 2003 | I Am Geriatr Soc2003，51，4： | 1 |
| 14 | Human resources for mental health care:current situation and strategies for action显示文摘 | Kakuma R Minas S van Ginneken N | 2011 | Lancet2011，378，9803： | 1 |
| 15 | Nakazato M Yoshimatsu H Pancreatic stem/progenitor cells for the treatment of diabetes显示文摘 | Noguchi H Masaki T Kakuma T | 2010 | Rev Diabet Stud2010，7，2： | 1 |
| 16 | Maternal dietary antigen avoidance during pregnancy or lactation,or both,for preventing or treating atopic disease in the child显示文摘 | Kramer MS Kakuma R | | 0，，03： | 1 |
| 17 | Comparing the hypothalamie and extrahypothalamic actions of endogenous hyperleptinemia显示文摘 | Wang Z W Zhou Y T Kakuma T | 1999 | Proc Nail Acad Sci USA1999，96，10： | 1 |
| 18 | Effect of CPAP treatment on residual depressive symptoms in patients with major depression and coexisting sleep apnea: contribution of daytime sleepiness to residual depressive symptoms 显示文摘 | Habukawa M Uchimura N Kakuma T | 2010 | Sleep Med2010，11，6： | 1 |
| 19 | The optimal duration of exclusive breastfeeding , a systematic review 显示文摘 | Kramer MS Kakuma R | 2004 | Adv Exp Med Bioi2004，554，： | 1 |
| 20 | Leptin troglitazone,and the expressing of sterol regulatory element binding proteins in liver and pancreatic islets显示文摘 | Kakuma T Lee Y Higa M | 2000 | Proceedings of the National Academy of Sciences of the United States of America2000，，97： | 1 |
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