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| 1 | Endoscopic submucosal dissection for gastrointestinal neoplasms显示文摘Endoscopic submucosal dissection (ESD) is an advanced technique of therapeutic endoscopy for superficial gastrointestinal neoplasms. Three steps characterize it:injecting fluid into the submucosa to elevate the lesion, cutting the surrounding mucosa of the lesion, and dissecting the submucosa beneath the lesion. The ESD technique has rapidly permeated in Japan for treatment of early gastric cancer, due to its excellent results of en- bloc resection compared to endoscopic mucosal resection (EMR). Although there is still room for improvement to lessen its technical difficulty, ESD has recently been applied to esophageal and colorectal neoplasms. Favorable short-term results have been reported, but the application of ESD should be well considered by three aspects:(1) the possibility of nodal metastases of the lesion, (2) technical difficulty such as location, ulceration and operator’s skill, and (3) organ characteristics. | Naomi Kakushima Mitsuhiro Fujishiro | 2008 | World Journal of Gastroenterology2008，14，19： | 95 |
| 2 | Diagnosis of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP) is a distinct form of chronic pancreatitis that is increasingly being reported. The presentation and clinical image findings of AIP sometimes resemble those of several pancreatic malignancies, but the therapeutic strategy differs appreciably. Therefore, accurate diagnosis is necessary for cases of AIP. To date, AIP is classified into two distinct subtypes from the viewpoints of etiology, serum markers, histology, other organ involvements, and frequency of relapse: type 1 is related to Ig G4(lymphoplasmacytic sclerosing pancreatitis) and type 2 is related to a granulocytic epithelial lesion(idiopathic duct-centric chronic pancreatitis). Both types of AIP are characterized by focal or diffuse pancreatic enlargement accompanied with a narrowing of the main pancreatic duct, and both show dramatic responses to corticosteroid. Unlike type 2, type 1 is characteristically associated with increasing levels of serum Ig G4 and positive serum autoantibodies, abundant infiltration of Ig G4-positive plasmacytes, frequent extrapancreatic lesions, and relapse. These findings have led several countries to propose diagnostic criteria for AIP, which consist of essentially similar diagnostic items; however, several differences exist for each country, mainly due to differences in the definition of AIP and the modalities used to diagnose this disease. An attempt to unite the diagnostic criteria worldwide was made with the publication in 2011 of the international consensus diagnostic criteria for AIP, established at the 2010 Congress of the International Association of Pancreatology(IAP). | Hiroyuki Matsubayashi Naomi Kakushima Kohei Takizawa Masaki Tanaka Kenichiro Imai Kinichi Hotta Hiroyuki Ono | 2014 | World Journal of Gastroenterology2014，20，44： | 17 |
| 3 | Treatment for superficial non-ampullary duodenal epithelial tumors显示文摘Because of the low prevalence of non-ampullary duodenal epithelial tumors(NADETs),standardized clinical management of sporadic superficial NADETs,including diagnosis,treatment,and follow-up,has not yet been established.Retrospective studies have revealed certain endoscopic findings suggestive of malignancy.Duodenal adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive surgery.The use of endoscopic treatment including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),for the treatment for superficial NADETs is increasing.EMR requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after resection.ESD provides an excellent complete resection rate,however it remains a challenging method,considering the high risk of intraoperative or delayed perforation.Minimally invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic treatment.Pancreaticoduodenectomy remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion,which presents a risk of lymph node metastasis.Endoscopic or surgical treatment outcomes of superficial NADETs without submucosal invasion are satisfactory.Establishing an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment. | Naomi Kakushima Hideyuki Kanemoto Masaki Tanaka Kohei Takizawa Hiroyuki Ono | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 4 | Endoscopic ultrasonography guided-fine needle aspirationfor the diagnosis of solid pancreaticobiliary lesions:Clinicalaspects to improve the diagnosis显示文摘Endoscopic ultrasonography-guided fine-needle aspiration(EUS-FNA) has been applied to pancreaticobiliary lesions since the 1990 s and is in widespread use throughout the world today. We used this method to confirm the pathological evidence of the pancreaticobiliary lesions and to perform suitable therapies. Complications of EUS-FNA are quite rare, but some of them are severe. Operators should master conventional EUS observation and experience a minimum of 20-30 cases of supervised EUS-FNA on non-pancreatic and pancreatic lesions before attempting solo EUSFNA. Studies conducted on pancreaticobiliary EUSFNA have focused on selection of suitable instruments(e.g., needle selection) and sampling techniques(e.g., fanning method, suction level, with or without a stylet, optimum number of passes). Today, the diagnostic ability of EUS-FNA is still improving; the detection of pancreatic cancer(PC) currently has a sensitivity of 90%-95% and specificity of 95%-100%. In addition to PC, a variety of rare pancreatic tumors can be discriminated by conducting immunohistochemistry on the FNA materials. A flexible, large caliber needle has been used to obtain a large piece of tissue, which can provide sufficient histological information to be helpful in classifying benign pancreatic lesions. EUSFNA can supply high diagnostic yields even for biliary lesions or peri-pancreaticobiliary lymph nodes. This review focuses on the clinical aspects of EUS-FNA in the pancreaticobiliary field, with the aim of providing information that can enable more accurate and efficient diagnosis. | Hiroyuki Matsubayashi Toru Matsui Yohei Yabuuchi Kenichiro Imai Masaki Tanaka Naomi Kakushima Keiko Sasaki Hiroyuki Ono | 2016 | World Journal of Gastroenterology2016，22，2： | 12 |
| 5 | Risk of lymph node metastases from intramucosal gastric cancer in relation to histological types: how to manage the mixed histological type for endoscopic submucosal dissection显示文摘 | Kohei Takizawa Hiroyuki Ono Naomi Kakushima Masaki Tanaka Noriaki Hasuike Hiroyuki Matsubayashi Yuichiro Yamagichi Etsuro Bando Masanori Terashima Kimihide Kusafuka Takashi Nakajima | 2013 | Gastric Cancer2013，，4： | 4 |
| 6 | Si nanowire FET and its modeling显示文摘Because of its ability to effectively suppress off-leakage current with its gate-around conffguration, the Si nanowire FET is considered to be the ultimate structure for ultra-small CMOS devices to the extent that the devices would be approaching their downsized limits. Recently, several experimental studies of Si nanowire FETs with on-currents much larger than those of planar MOSFETs have been published. Consequently, Si nanowire FETs are now gaining significant attention as the most promising candidate for mainstream CMOS devices in the 2020s. To enable the introduction of the Si nanowire FETs into integrated circuits, good compact models, which circuit designers can easily handle, are essential. However, it is a very challenging task to establish such a compact model, because the ID - VD characteristics of Si nanowire FETs are affected by the band structure of the nanowire, which is very sensitive to the nanowire diameter, cross-sectional shape, crystal orientation, mechanical stress and interface states. In this paper, the recent status of research on Si nanowire FETs in experimental and theoretical studies is described. | IWAI Hiroshi NATORI Kenji SHIRAISHI Kenji IWATA Jun-ichi OSHIYAMA Atsushi YAMADA Keisaku OHMORI Kenji KAKUSHIMA Kuniyuki AHMET Parhat | 2011 | Science China(Information Sciences)2011，54，5： | 4 |
| 7 | Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas显示文摘AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors(NADETs).METHODS:Clinicopathological data were reviewed for84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September2002 and August 2014 at a single prefectural cancer center.Superficial NADETs were defined as lesions confined to the mucosa or submucosa.Demographic and clinicopathological data were retrieved from charts,endoscopic and pathologic reports.Endoscopic reports included endoscopic diagnosis,location,gross type,diameter,color,and presence or absence of biopsy.Endoscopic diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were obtained.Endoscopic images were obtained using routine,front-view,high-resolution video endoscopy,and chromoendoscopy with indigocarmine was performed for all lesions.Endoscopic images were reviewed by at least two endoscopists to assess endoscopic findings indicative of carcinoma.Preoperative diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected specimens.Sensitivity,specificity,and accuracy were assessed for endoscopic diagnosis and biopsy diagnosis.RESULTS:The majority(81%)of the lesions were located in the second portion of the duodenum.The median lesion diameter was 14.5 mm according to final histology.Surgery was performed for 49 lesions from 39 patients,and 35 lesions from 35 patients were endoscopically resected.Final histology confirmed 65carcinomas,15 adenomas,and 3 hyperplasias.A finaldiagnosis of duodenal carcinoma was made for 91%(52/57)of the lesions diagnosed as carcinoma by endoscopy and 93%(42/45)of the lesions diagnosed as carcinoma by biopsy.The sensitivity,specificity,and accuracy of endoscopic diagnoses were 80%,72%,and 78%,respectively,whereas those of biopsy diagnoses were 72%,80%,and 74%,respectively.Preoperative diagnoses of carcinomas were made in88%(57/65)of the carcinoma lesions via endoscopy or biopsy.Endoscopic findings associated with carcinoma were red color,depression,and mixed-type morphology.CONCLUSION:Preoperative endoscopy and biopsy showed similar accuracies in the diagnosis of carcinoma in patients with superficial NADETs. | Naomi Kakushima Hideyuki Kanemoto Keiko Sasaki Noboru Kawata Masaki Tanaka Kohei Takizawa Kenichiro Imai Kinichi Hotta Hiroyuki Matsubayashi Hiroyuki Ono | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 8 | Method and timing of resection of superficial non‐ampullary duodenal epithelial tumors显示文摘 | Naomi Kakushima Hiroyuki Ono Toshitatsu Takao Hideyuki Kanemoto Keiko Sasaki | 2014 | Digestive Endoscopy2014，，： | 3 |
| 9 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 2 |
| 10 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 11 | A Multicenter Survey of the Management After Gastric Endoscopic Submucosal Dissection Related to Postoperative Bleeding显示文摘 | Osamu Goto Mitsuhiro Fujishiro Ichiro Oda Naomi Kakushima Yorimasa Yamamoto Yosuke Tsuji Ken Ohata Takashi Fujiwara Junko Fujiwara Naoki Ishii Chizu Yokoi Shinichi Miyamoto Toshiyuki Itoh Shinji Morishita Takuji Gotoda Kazuhiko Koike | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 12 | Clinical outcomes of endoscopic submucosal dissection for early gastric cancer in remnant stomach or gastric tube显示文摘 | N. Nishide H. Ono N. Kakushima K. Takizawa M. Tanaka H. Matsubayashi Y. Yamaguchi | 2012 | Endoscopy2012，，06： | 2 |
| 13 | Endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors in J apan: M ulticenter case series显示文摘 | Kenichi Goda Daisuke Kikuchi Yorimasa Yamamoto Kengo Takimoto Naomi Kakushima Yoshinori Morita Hisashi Doyama Takuji Gotoda Yuji Maehata Noritsugu Abe | 2014 | Digestive Endoscopy2014，，： | 2 |
| 14 | Successful endoscopic en bloc resection of a large laterally spreading turnout in the rectosimoid junction by endoscopic submucosal dissection显示文摘 | FUJISHIRO M YAHAGI N KAKUSHIMA N | 2006 | Gastrointestinal Endoscopy2006，1，： | 1 |
| 15 | Percutaneous endoscopic gastrostomy using the direct method for aerodigestive cancer patients显示文摘 | Yagishita A Kakushima N Tanaka M | 2012 | Eur J Gastroenterol Hepatol2012，24，1： | 1 |
| 16 | Endoscopic submueo-sal dissection of esophageal squamous cell neoplasms 显示文摘 | Fujishiro M Yahagi N Kakushima N | 2006 | Clin Gastroenterol Hepatol2006，4，6： | 1 |
| 17 | Comparison of Various Submucosal Injection Solutions for Maintaining Mucosal Elevation During Endoscopic Mucosal Resection显示文摘 | M. Fujishiro N. Yahagi K. Kashimura Y. Mizushima M. Oka S. Enomoto N. Kakushima K. Kobayashi T. Hashimoto M. Iguchi Y. Shimizu M. Ichinose M. Omata | 2004 | Endoscopy2004，，07： | 1 |
| 18 | Endoscopic submucosal dissection of esophageal squamous cell neoplasms 显示文摘 | Fujishiro M Yahagi N Kakushima N | 2006 | Clin Gastroenterol Hepatol2006，4，6： | 1 |
| 19 | Technical feasibility of endoscopie submucosal dissection for gastric neoplasms in the elderly Japanese population 显示文摘 | KAKUSHIMA N FUJISHITO M KODASHIMA S | 2007 | J Gastroenteml Hepatol2007，22，3： | 1 |
| 20 | Endoscropic submucosal dissection for rectal epithelial neoplasia显示文摘 | YAHAGI N NAKAMURA M KAKUSHIMA N | 2006 | Endoscopy2006，38，5： | 1 |
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