| 3 | 醛固酮与肾素比值可预测非典型原发性 醛固酮增多症患者的心脏代谢紊乱情况显示文摘醛固酮与肥胖、代谢综合征(metabolic syndrome,MS)、炎症和血栓前状态有关;然而,大多数研究将这些指标与原发性醛固酮增多症(primary aldosteronism,PA)联系起来,排除了非PA的患者。本研究旨在确定在非PA人群中醛固酮、肾素或血浆醛固酮与肾素比值(plasma aldosterone to renin ratio,ARR)与代谢紊乱和炎症/血管生物标志物是否相关。方法:对275例患者(包括2种性别和青少年)进行血浆和尿醛固酮检测,并测定血浆肾素活性。在所有受试者中,MS的诊断根据美国国家胆固醇教育计划成人治疗组(adult treatment panel,ATP)第三次报告Ⅲ(ATPⅢ)来确定,并对代表肾脏、血管、炎症和盐皮质激素活性的生物标记物进行评估。 | 陈云(编译) 叶鹏(审校) Vecchiola A Fuentes CA Barros ER Martínez-Aguayo A García H Allende F Solari S Olmos R Carvajal C Tapia-Castillo A Campino C Kalergis AM Baudrand R Fardella CE | 2020 | 中华高血压杂志2020，28，4： | 1 |
| 5 | Role of Salmonella enterica exposure in Chilean Crohn's disease patients显示文摘AIM:To study the association between exposure toSalmonella enterica(SE)and Crohn’s disease(CD)and its clinical implications in Chilean patients.METHODS:Ninety-four unrelated Chilean CD patients from CAREI(Active Cohort Registry of Inflammatory Bowel Disease)presenting to a single inflammatory bowel disease(IBD)unit of a University Hospital were prospectively included in this study.A complete clinical evaluation,including smoking history,was performed at the initial visit,and all the important data of clinical evolution of CD were obtained.Blood samples from these CD patients and 88 healthy sex-and agematched control subjects were analyzed for exposure to SE and for their NOD2/CARD15 gene status using the presence of anti-Salmonella lipopolysaccharide antibodies[immunoglobulin-G type(IgG)]and polymerase chain reaction(PCR),respectively.We also evaluated exposure to SE in 90 sex-and age-matched patients without CD,but with known smoking status(30 smokers,30 non-smokers,and 30 former smokers).RESULTS:CD patients comprised 54 females and 40males,aged 35.5±15.2 years at diagnosis with a mean follow-up of 9.0±6.8 years.CD was inflammatory in 59 patients(62.7%),stricturing in 24(25.5%)and penetrating in 15(15.5%).Thirty cases(31.9%)had lesions in the ileum,29(30.8%)had ileocolonic lesions,32(34.0%)had colonic lesions and 23(24.4%)had perianal disease.Sixteen CD patients(17%)were exposed to SE compared to 15(17%)of 88 healthy control subjects(P=0.8).Thirty-one CD patients(32.9%)were smokers,and 7(7.4%)were former smokers at diagnosis.In the group exposed to SE,10 of 16 patients(62.5%)were active smokers compared to 21 of 78 patients(26.9%)in the unexposed group(P=0.01).On the other hand,10 of 31 smoking patients(32%)were exposed to SE compared to 5 of 56 nonsmoking patients(9%),and one of the seven former smokers(14%)(P=0.01).In the group of 90 patients without CD,but whose smoking status was known,there was no differ-ence in exposure to SE[3 of 30 smokers(10%),5 of30 non-smokers(16%),and 5 of 30 former smokers(16%);P=0.6].There were no differences in disease severity between CD patients with and those without anti-SE IgG antibodies,estimated as the appearance of stricturing[2(12.5%)vs 22(28.2%);P=0.2]or penetrating lesions[2(12.5%)vs 13(16.6%);P=1.0];or the need for immunosuppressants[11(68.7%)vs 55(70.5%);P=1.0],anti-tumor necrosis factor therapy[1(6.2%)vs 7(8.9%);P=1.0],hospitalization[13(81.2%)vs 58(74.3%);P=0.7],or surgery[3(18.7%)vs 12(15.3%);P=0.3),respectively].No other factors were associated with SE,including NOD2/CARD15 gene status.Seventeen CD patients(18%)had at least one mutation of the NOD2/CARD15 gene.CONCLUSION:Our study found no association between exposure to SE and CD.We observed a positive correlation between SE exposure and cigarette smoking in Chilean patients with CD,but not with disease severity. | Manuel Alvarez-Lobos Daniela P Pizarro Christian E Palavecino Abner Espinoza Valentina P Sebastián Juan C Alvarado Patricio Ibaez Carlos Quintana Orlando Díaz Alexis M Kalergis Susan M Bueno | 2013 | World Journal of Gastroenterology2013，19，35： | 0 |
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