5篇
您的检索式：作者名="Kalpalatha"
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| 1 | Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases显示文摘AIM To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis(HLH) in the intensive care unit(ICU).METHODS We performed a retrospective observational study of adult patients with the diagnosis of 'HLH' admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society.RESULTS Sixteen adult cases of HLH were admitted to the medical ICUs over 4 years.Median age of presentation was 49 years and 10(63%) were males. Median Sequential Organ Failure Assessment(SOFA) score at the time of ICU admission was 10. Median ICU length of stay(LOS) was 11.5 d and median hospital LOS was 29 d. Septic shock and acute respiratory failure accounted for majority of diagnoses necessitating ICU admission. Septic shock was the most common ICU complication seen in(88%) patients, followed by acute kidney injury(81%) and acute respiratory failure requiring mechanical ventilation(75%). Nine patients(56%) developed disseminated intravascular coagulation and eight(50%) had acute liver failure. 10 episodes of clinically significant bleeding were observed.Multi system organ failure was the most common cause of death seen in 12(75%)patients. The 30 d mortality was 37%(6 cases) and 90 d mortality was 81%(13 cases). There was no difference in mortality based on age(above or less than 50 years), SOFA score on ICU admission(more than or less than 10),immunosuppression, time to diagnose HLH or direct ICU admission versus floor transfer.CONCLUSION HLH is a devastating disease associated with poor outcomes in ICU. Intensivists need to have a high degree of clinical suspicion for HLH in patients with septic shock/multi system organ failure and progressive bi/pancytopenia who are not responding to standard management in ICU. | Sumit Kapoor Christopher K Morgan Muhammad Asim Siddique Kalpalatha K Guntupalli | 2018 | World Journal of Critical Care Medicine2018，7，6： | 3 |
| 2 | Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome显示文摘 | Alejandro C. Arroliga B Taylor Thompson Marek Ancukiewicz Jeffrey P. Gonzales Kalpalatha K. Guntupalli Pauline K. Park Herbert P. Wiedemann Antonio Anzueto | 2008 | Critical Care Medicine2008，，4： | 1 |
| 3 | Drought response in the spikes of barley: gene expression in the lemma, palea, awn, and seed显示文摘 | Tilahun Abebe Kalpalatha Melmaiee Virginia Berg Roger P. Wise | 2010 | Functional & Integrative Genomics2010，，2： | 1 |
| 4 | Critical illness in pregnancy:part ]I :common medical conditions complica- ting pregnancy and puerperium 显示文摘 | Kalpalatha KG Dilip RK Venkata B | 2015 | Chest2015，148，5： | 1 |
| 5 | Heart failure in general and cardiac transplant patients with COVID-19显示文摘Coronavirus disease 2019(COVID-19)is primarily an infection of the respiratory tract,but it can have multisystem manifestations.Cardiac complications of COVID-19 can range from acute myocardial injury,cardiac arrhythmias,or heart failure,amongst others.Heart failure(HF)in COVID-19 can be a de novo process or due to worsening of pre-existing cardiovascular ailment.HF in a patient with COVID-19 not only poses challenges in clinical presentation and management of COVID-19 but also affect prognosis of the patient.This article aims to succinctly revisit the implications of this pandemic regarding pre-existing HF or new-onset HF based on prevailing data.It also focuses on the management and special recommendations from prior studies and guidelines. | Munish Sharma Gowthami Sai Kogilathota Jagirdhar Kalpalatha K Guntupalli Rahul Kashyap Salim Surani | 2022 | World Journal of Cardiology2022，14，7： | 1 |
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