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| 1 | Regio and enantioselectire reduction of t-butyl 6-chloro-3,5-dioxohexanoate with baker's yeast显示文摘 | Wolberg M Kaluzna I Muller M | 2004 | Tetrahedron: Asym2004，15，18： | 1 |
| 2 | Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C显示文摘AIM To evaluate the association of IFNL3(IL28B) SNP rs4803217 with severity of disease and treatment outcome in chronic hepatitis C(CHC).METHODS The study enrolled 196 CHC Polish patients(82 women and 114 men in age 20-64) infected with hepatitis C virus(HCV) genotype 1. They were treatment na?ve and qualified to pegylated interferon alpha(PEG-IFN-α) and ribavirin(RBV) therapy. The analyzed baseline parameters included: degree of inflammation, stage of fibrosis, viral load as well as alanine aminotransferase(ALT), asparagine aminotransferase(AST) and total bilirubin(TBIL). The analysis of response to therapy included: sustained virological response(SVR), defined as undetectable serum HCV RNA level six month after completion of 48-wk therapy, and relapse, defined as achieving undetectable viral load at the end of treatment but not SVR. HCV genotyping and HCV RNA quantification were performed using commercially available tests. DNA was isolated from peripheral blood mononuclear cells or from buccal cell swabs. In addition to rs4803217, also single nucleotide polymorphisms(SNPs)(rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed. SNPs were determined by high resolution melt analysis and confirmed by sequencing of amplicons. RESULTS Frequency of rs4803217 genotypes in studied group was as follows: 27.55%; 54.59% and 17.86% for CC, CA and AA, respectively. The rs4803217 SNP, similar to other analyzed SNPs, was not associated with severity of CHC(grade of inflammation, stage of fibrosis, baseline viral load as well as biochemical parameters: ALT, AST, TBIL). It was demonstrated that the rs4803217 C allele is associated with SVR(C vs A: P < 0.0001; dose of C allele: P = 0.0002) and nonrelapse(C vs A: P = 0.001; dose of C allele: P = 0.002). Moreover, it was found that patients with CC genotype have significantly higher response rates as compared with CA/AA patients(P < 0.0001), whereas patients carrying A allele are significantly predisposed to relapse after treatment(P = 0.0007). Moreover, the association of rs4803217 with SVR was comparable to that of rs12979860 and stronger as observed for rs12980275 and rs8099917. Association of rs4803217 with relapse, was the strongest as compared with the other SNPs. The analysis of combined rs4803217 and rs8099917 genotypes demonstrated that additional genotyping of rs8099917 had no significant impact on the prediction of SVR. Multivariate analysis revealed that among analyzed SNPs only rs4803217 is an independent predictor of SVR(P = 0.016) and relapse(P = 0.024). CONCLUSION The rs4803217 SNP is a strong, independent and superior predictor of SVR and relapse in HCV genotype 1 infected CHC patients treated with PEG-IFN-α and RBV. | Bogna Swiatek-Koscielna Ewelina Kaluzna Ewa Strauss Jerzy Nowak Iwona Bereszyńska Ewelina Gowin Jacek Wysocki Jolanta Rembowska Dominika Barcińska Iwona Mozer-Lisewska Danuta Januszkiewicz-Lewandowska | 2017 | World Journal of Gastroenterology2017，23，21： | 1 |
| 3 | Systematic investigation of Saccharomyces cerevisiae enzymes catalyzing carbonyl reductions显示文摘 | Kaluzna IA Matsuda T Sewell AK | | 0，，40： | 1 |
| 4 | Regio and enantiose- lective reduction of t-butyl 6-chloro-3,5-dioxohexano- ate with bakers yeast显示文摘 | Wolberg M Kaluzna L Muller M | 2004 | Tetrahedron: Asymm2004，15，： | 1 |
| 5 | Stereoselective,biocatalytic reductions of ct-chloro-β-keto esters显示文摘 | Kaluzna IA Feske BD Wittayanan W | | 0，，01： | 1 |
| 6 | Systematic investigation of Saccharomyces cerevisiae enzymes catalyzing carbonyl reductions显示文摘 | Kaluzna I A Matsuda T Sewell A K | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 7 | Ketore ductases: stereoselective catalysts for the facile syn thesis of ehiral alcohols显示文摘 | Kaluzna I A Rozzell J D Kambourakis S | 2005 | Tetrahedron: Asymmetry2005，16，22： | 1 |
| 8 | 查看详情显示文摘 | Kaluzna I Andrew A.A Bonilla M Martzen M.R Stewart J.D | | 0，，： | 1 |
| 9 | Systematic investigation of Saccharomyces cerevisiae enzymes catalyzing carbonyl reductions显示文摘 | Kaluzna I.A Matsuda T Sewell A.K Stewart J.D | | 0，，40： | 1 |
| 10 | Systematic investigation of Saccharomyces cerevisiae enzymes catalyzing carbonyl reductions显示文摘 | Kaluzna I A Matsuda T Sewell A K | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 11 | Stereoselective, biocatalytic reductions of a-chloro-/3-keto esters 显示文摘 | Kaluzna I A Feske B D Wittayanan W | 2005 | J Org Chem2005，70，： | 1 |
| 12 | Systematic investigation of Saccharomyces cerevisiae enzyme catalyzing carbonyl reductions 显示文摘 | Kaluzna 1 A Matsuda T Sewell A K | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 13 | Stereoselective, biocatalytic reductions of ct-chloro-13-keto esters 显示文摘 | Kaluzna IA Feske BD Wittayanan W | 2005 | J Org Chem2005，70，1： | 1 |
| 14 | Regio and enantioselective reduction of t-butyl 6-chloro-3,5-dioxohexanoate with baker's yeast显示文摘 | Wolberg M Kaluzna IA Muller M | 2004 | Tetrahedron:Asymm2004，15，： | 1 |
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