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| 1 | 含有开关参数化物理过程的模式变分资料同化的非光滑优化方法:几个理论问题显示文摘时间、空间上离散的模式如果含有带开关的参数化物理过程,某些对应的变分同化问题可以看成为非光滑优化问题.本文系统地讨论了与此相关的几个理论问题.首先,利用次梯度这个非光滑优化中的基本概念可以对通常的伴随方程的解进行清楚的解释和定义.利用一个带对流调整的多层扩散模式,演示了通常的伴随方程的解在奇异点处不是由代价函数的Gateaux导数构成,而是代价函数的一个次梯度.其次,在非光滑优化的框架下对现有的解决这类问题的方法进行了评述.这些方法包括:(1)利用光滑优化方法和通常的伴随模式,并且讨论了这个方法的收敛条件;(2)正则化方法.这个方法是把模式中不光滑的项用光滑的项近似,以把问题变为光滑优化问题.(3)次梯度方法.这个方法利用通常的伴随模式来计算一个次梯度,是收敛的算法,不过收敛速度很慢.(4)非光滑优化中的Bundle方法.这个方法比次梯度方法收敛得快,不过需要利用所有的次梯度信息.由于计算所有的次梯度十分困难,现有的Bundle方法大都进行了一些改变,仅需要用户能够计算出一个次梯度.不过这个改变是无奈的,多个次梯度的信息可以提高Bundle方法的效率.本文最主要的工作是提出了集值伴随方程的概念.集值伴随模式可以在奇异点处计算出所有支撑次梯度,因此利用集值伴随方程有可能提出基于Bundle方法的更好算法. | 朱江 Masafumi Kamachi 周广庆 | 2002 | Advances in Atmospheric Sciences2002，19，3： | 14 |
| 2 | Significance of functional hepatic resection rate calculated using 3D CT/^(99m)Tc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging显示文摘AIM: To evaluate the usefulness of the functional hepatic resection rate(FHRR) calculated using 3D computed tomography(CT)/^(99m)Tc-galactosyl-human serum albumin(GSA) single-photon emission computed tomography(SPECT) fusion imaging for surgical decision making. METHODS: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and March 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynamic multidetector CT and ^(99m)Tc-GSA scintigraphy. We compared the parenchymal hepatic resection rate(PHRR) with the FHRR, which was defined as the resection volume counts per total liver volume counts on 3D CT/^(99m)Tc-GSA SPECT fusion images.RESULTS: In total, 50 patients underwent bisectionectomy and seven underwent trisectionectomy.Biliary reconstruction was performed in 15 patients, including hepatopancreatoduodenectomy in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16(P < 0.0001). The ratio of FHRR to PHRR for patients with preoperative therapies(transcatheter arterial chemoembolization, radiation, radiofrequency ablation, etc.), large tumors with a volume of > 1000 m L, and/or macroscopic vascular invasion was significantly smaller than that for patients without these factors(0.73 ± 0.19 vs 0.82 ± 0.18, P < 0.05). Postoperative hyperbilirubinemia was observed in six patients. Major morbidities(Clavien-Dindo grade ≥ 3) occurred in 17 patients(29.8%). There was no case of surgeryrelated death.CONCLUSION: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepant owing to insufficient hepatic inflow and congestion in patients with preoperative therapies, macroscopic vascular invasion, and/or a tumor volume of > 1000 m L. | Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Shingo Shimada Kenji Wakayama Tatsuya Orimo Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketomi | 2016 | World Journal of Gastroenterology2016，22，17： | 6 |
| 3 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 4 | Low-dose rectal diclofenac for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized controlled trial显示文摘 | Taiga Otsuka Seiji Kawazoe Shunya Nakashita Saori Kamachi Satoshi Oeda Chinatsu Sumida Takumi Akiyama Keisuke Ario Masaru Fujimoto Masanobu Tabuchi Takahiro Noda | 2012 | Journal of Gastroenterology2012，，8： | 4 |
| 5 | 改进的切线性模式对一个边界层模式变分资料同化的改善(英文)显示文摘大气、海洋中边界层物理过程的强非线性会对切线性模式近似(尤其是当积分时间长时)有较大的影响,从而给相应的4维变分资料同化问题的求解造成困难。本文构造了Mellor—Yamada湍流封闭模式(level2.5)的一个改进的切线性模式,相比通常的切线性模式和简化的切线性模式可以提高对非线性扰动的逼近。利用这个改进的切线性模式的伴随模式分别进行了1到7天的变分资料同化试验,得到了满意的结果。而用通常的伴随模式和简化的伴随模式都无法得到令人满意的结果。 | 朱江 王辉 Masafumi Kamachi | 2002 | Advances in Atmospheric Sciences2002，19，4： | 4 |
| 6 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 7 | α-fetoprotein,vascular endothelial growth factor receptor-1 and early recurrence of hepatoma显示文摘AIM:To investigate whether α-fetoprotein (AFP) and vascular endothelial growth factor receptor (VEGFR)-1 correlate with early recurrence of hepatoma/hepatocel-lular carcinoma (HCC).METHODS:From 2000 to 2005,114 consecutive pa-tients with HCC underwent primary curative hepatecto-my.The mean age was 60.7 (8.7) years and 94 patients were male.The median follow-up period was 71.2 mo (range:43-100 mo).Immediately prior to commencing laparotomy,5 mL bone marrow was aspirated from thesternum and collected in citrate-coated test tubes.The initial 2 mL of bone marrow aspirate was discarded in each case.AFP mRNA and VEGFR-1 mRNA in the bone marrow and peripheral blood (BM-and PH-AFP mRNA and BM-and PH-VEGFR-1 mRNA,respectively) were measured by real-time quantitative reverse transcription polymerase chain reaction.As normal controls,VEGFR-1 mRNA in the bone marrow and peripheral blood was also measured in 11 living liver donors.These data were evaluated for any correlation with early recurrence,comparing clinical and pathological outcomes.RESULTS:The cut-off value of the BM-AFP mRNA and PH-AFP mRNA level in patients with HCC was set at 1.92 × 10-7 and zero,respectively,based on data from the controls.A total of 34 (29.8%) and six (5.4%) patients were positive for BM-AFP mRNA and PH-AFP mRNA,respectively.The BM-VEGFR-1 mRNA levels in all HCC patients were higher than those in the normal con-trols,and this was the case also for PH-VEGFR-1mRNA.The 25-percentile values for the BM-and PH-VEGFR-1 mRNA in HCC patients were used as the cut-off values for assigning the patients into two groups based on these transcript levels.The High group for BM-VEG-FR-1 mRNA contained 81 (71.1%) HCC cases and the Low group was assigned 33 (28.9%) patients.These numbers for PH-VEGFR-1mRNA were 78 (75.0%) and 26 (25.0%),respectively.HCC recurred in 80 patients;in the remnant liver in 48 cases,in the remnant liver and remote tissue in 20,and in the remote tissue alone in 12.BM-AFP mRNA-positive cases showed a signifi-cantly higher rate of early recurrence (within 1 year of surgical treatment) compared with BM-AFP mRNA-negative patients (P=0.0091).Patients were classified into four groups according to the level/status of their BM-VEGFR-1 and BM-AFP mRNA as follows:group A (n=23),BM-VEGFR-1/BM-AFP mRNA=low/negative;group B (n=57) high/negative;group C (n=10) low/positive;group D (n=24),high/positive.This classifi-cation was found to correlate with a recurrence of thisdisease within 1 year (P=0.0228).The disease-free survival curve of group A was significantly better than that of groups B,C or D (P=0.0437,P=0.0325,P=0.0225).No other classification (i.e.,PH-VEGF-R1/BM-AFP,BM-VEGF-R1/PH-AFP,and PH-VEGF-R1/PH-AFP mRNA) showed such a correlation.CONCLUSION:The evaluation of BM-AFP and BM-VEG-FR-1 mRNA in patients with HCC may be a valuable pre-dictor of disease recurrence following curative resection. | Toshiya Kamiyama Masato Takahashi Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Nozomi Kobayashi Michitaka Ozaki Satoru Todo | 2012 | World Journal of Gastroenterology2012，18，4： | 2 |
| 8 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 9 | High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection显示文摘Background:Currently,the population with type 2 diabetes mellitus(DM)is increasing worldwide.However,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is unclear.Methods:We analyzed 756 patients with HCC who underwent hepatectomy.These patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1c<7.0%(L-A1c;n=656)group depending on their HbA1c level at admission.We investigated prognoses,clinicopathological characteristics and surgical outcomes including morbidities of HCC patients with high HbA1c,prognoses according to the treatment for DM were also investigated.Results:Among all patients and those with hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,overall survival(OS)and relapse-free survival(RFS)did not differ significantly between the H-A1c and L-A1c groups.In contrast,the 5-year OS rate of the H-A1c group was 55%and that of the L-A1c group 71%among patients without HBV and HCV(NBNC patients)(P=0.03).Among NBNC patients,the median RFS of the H-A1c group was 13 months,and that of the L-A1c group was 26 months(P=0.02).In addition,metformin use was an independent favorable factor for both OS and RFS.The H-A1c group had significantly higher rates of hyperbilirubinemia,wound infection,and pneumonia.Conclusions:HCC patients with high HbA1c might have poor prognoses for both survival and recurrence in NBNC-HCC.High HbA1c may also be a risk factor for morbidities after hepatectomy.Metformin use may constitute a good option for NBNC patients with HCC. | Shingo Shimada Toshiya Kamiyama Tatsuya Orimo Akihisa Nagatsu Hirofumi Kamachi Akinobu Taketomi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 2 |
| 10 | Regulation of apoptotic cell death by cytokines in a human salivary gland cell line:distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor alpha and interferon gamma显示文摘 | Kamachi M Kawakami A Yamasaki S | | 0，，： | 1 |
| 11 | Allergic bronchopulmonary aspergillosis in a 2-year-oht asthmatic boy with immune dysregulation, polyendocrinopathy, enter- opathy, X-linked 显示文摘 | Ohshima M Futamura M Kamachi Y | 2009 | Pediatric Pulmonology2009，44，3： | 1 |
| 12 | Intracellular distribution of macrophage migration inhibitory factor predicts the prognosis of patients with lung adenocarcinoma显示文摘 | S Ogura A Kamimura M Kamachi J Nishihira K Yamazaki H Dosaka-Akita Y Kawakami | 2000 | Lung Cancer2000，，： | 1 |
| 13 | Pairing SOX off:with partners in the regulation of embryonic development显示文摘 | UCHIKAWA M KONDOH H | 2000 | Trends Genet2000，16，4： | 1 |
| 14 | Synthesis and structure-activity relationships of a new series of cephalosporins,BMY-28142 and related compounds显示文摘 | Naito T Aburaki S Kamachi H | 1986 | J Antibiot(Tokyo)1986，39，8： | 1 |
| 15 | A model investigation of the shearing characteristics in equal channel angular pressing 显示文摘 | Kamachi M Furukawa M Horita Z | 2002 | Materials Science and Engineering2002，347，122： | 1 |
| 16 | Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction显示文摘 | Kamachi Y Uchikawa M Collignon J | 1998 | Development1998，25，： | 1 |
| 17 | Corrosion assessment of nitric acid grade austenitic stainless steels显示文摘 | S. Ningshen U. Kamachi Mudali G. Amarendra Baldev Raj | 2008 | Corrosion Science2008，，2： | 1 |
| 18 | Continuous data assimilation of drifting buoy trajectory into an equatorial Pacific Ocean model显示文摘 | M Kamachi a J J O' Brien b | 1995 | Journal of Marine Systems1995，6，1： | 1 |
| 19 | Anomalously blue-shifted fluorescence and phosphorescence of zinc (II) tetraphenylporphyrin in highly constraining microenvironments in hydrophobically modified polysulfonates显示文摘 | Morishima Y Saegusa K Kamachi M | 1995 | Macromolecules1995，28，： | 1 |
| 20 | Hydrogen effects on pitting corrosion and semiconducting properties of nitrogencontaining type 316L stainless steel显示文摘 | Ningshen S Kamachi Mudali U | 2009 | Electrochim Acta2009，54，： | 1 |
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