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| 1 | 切开复位内固定结合植骨治疗髋关节置换术后Vanconver B1型股骨假体周围骨折显示文摘随着人工髋关节置换术数量和老年患者的增加,股骨假体周围骨折的发生率近年也逐渐增加,此类患者常伴有骨量丢失、骨缺损和假体移动等情况,治疗难度增加。有研究发现那些因骨折而行人工髋关节置换术的患者术后发生股骨周围骨折的概率是其他致伤原因患者的4.4倍,骨折的原因多为低能量损伤.以跌倒外伤最多。对于股骨假体周围骨折的分型,目前主要是依据Vanconver分型。此分型是依据股骨假体周围骨折的具体部位。而且对于假体的移动和骨骼本身的质量均作出了评估,对骨折的治疗有显著的临床意义,分为A、B、C3型。根据假体的松动性和股骨骨质量B型骨折可以分为3个亚型,B1型:骨折处假体周围较牢固;B2型:骨折处假体发生松动. | 罗元标 Yanmujiwa Kamau | 2013 | 中国骨与关节损伤杂志2013，28，8： | 9 |
| 2 | Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models显示文摘Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a pandemic worldwide.Currently,however,no effective drug or vaccine is available to treat or prevent the resulting coronavirus disease 2019(COVID-19).Here,we report our discovery of a promising an ti-COVID-19 drug can didate,the lipoglycopeptide antibiotic dalbava ncin,based on virtual screening of the FDA-approved peptide drug library combined with in vitro and in vivo functional antiviral assays.Our results showed that dalbavancin directly binds to human angiotensin-converting enzyme 2(ACE2)with high affinity,thereby blocking its interaction with the SARS-CoV-2 spike protein.Furthermore,dalbavancin effectively prevents SARS-CoV-2 replication in Vero E6 cells with an EC50 of~12 nM.In both mouse and rhesus macaque models,viral replication and histopathological injuries caused by SARS-CoV-2 infection are significantly inhibited by dalbavancin administration.Given its high safety and long plasma half-life(8-10 days)shown in previous clinical trials,our data indicate that dalbavancin is a promising anti-COVID-19 drug candidate. | Gan Wang Meng-Li Yang Zi-Lei Duan Feng-Liang Liu Lin Jin Cheng-Bo Long Min Zhang Xiao-Peng Tang Ling Xu Ying-Chang Li Peter Muiruri Kamau Lian Yang Hong-Qi Liu Jing-Wen Xu Jie-Kai Chen Yong-Tang Zheng Xiao-Zhong Peng Ren Lai | 2021 | Cell Research2021，31，1： | 6 |
| 3 | Neo- and Paleopolyploidy contribute to the species diversity of Asplenium the most species-rich genus of ferns显示文摘Polyploidy 广泛地在植物的进化被看作一个主要过程,但是多倍体种类差异的累积仍然是争论的。一些最近的研究与他们的双祖先相比在 neopolyploids 建议了增加的扑灭风险。多倍体蕨纲植物的高比例被期望主要被 neopolyploids 形成,而 paleopolyploid 种类被预言在整个染色体复制成立的 clades 被聚类。这里,我们由在导出的蕨纲植物家庭 Aspleniaceae 探索 polyploidy 的进化测试这预言。家庭有全球分布并且在所有蕨纲植物之中显示出多倍体 taxa 的最高的频率。测试假设,我们用代表 292 种类的 883 个标本的叶绿体 DNA 序列获得了全面发展史。所有出版染色体计数被印射到这个种系发生的框架上以便探索多倍体的进化。我们 Aspleniaceae 的历史上为几整个染色体复制恢复了证据。超过 tetraploid 水平的多倍体的种系发生的关系建议那 tetraploid Asplenium 种可能在这个家庭的某 clades 作为主要进化播放器代替了他们的双祖先。 | Harald Schneider Hong-Mei Liu Yan-Fen Chang Daniel Ohlsen Leon R. Perrie Lara Shepherd Michael Kessler Dirk N. Karger Sabine Hennequin Jeannine Marquardt Stephen Russell Stephen Ansell Ngan Thi Lu Peris Kamau Josmaily Loriga Ledis Regalado Jochen Heinrichs Atsushi Ebihara Alan R. Smith Mary Gibby | 2017 | Journal of Systematics and Evolution2017，55，4： | 2 |
| 4 | Traditional knowledge, use and conservation of plants by the communities of Tharaka-Nithi County, Kenya显示文摘Rural communities in Kenya largely depend on plant resources for their livelihood.The utilization of these resources depends on the availability of plant resources and the level of knowledge of the residents.We conducted an ethnobotanical study in Tharaka-Nithi County in Kenya to determine the knowledge and utilization of various plant species by the local communities.The study was conducted in four major administrative regions from June 2018 to February 2019,involving interview schedules using semi-structured open-ended questionnaires and guided field collections with 48 informants.A total of 214 plant species distributed in 73 families and 169 genera with 616 Use Reports(URs)were documented.Fabaceae was the highest family cited by the informants(31 species)followed by Lamiaceae and Euphorbiaceae(each with 11 species).Trees(49%)and shrubs(32%)were the top life forms of the plants frequently utilized by the local residents.The general plant uses reported were medicinal,food,fodder,construction,fuel,pesticidal,religious,live fencing,and making crafts.Zanthoxylum gilletii,Prunus africana,and Solanum incanum were found to be highly valued by the local communities.Plant utilization as food and medicinal uses against snake-bite related problems had the highest Informant Consensus Factor(ICF).Only 29(13.6%)of the species reported had their status assessed by the International Union for Conservation of Nature(IUCN).Conservation measures,alongside awareness creation in this region,are highly recommended for the species endemic to the region,highly depended on by the community,and those threatened according to IUCN standards. | Vivian Kathambi Fredrick Munyao Mutie Peninah Cheptoo Rono Neng Wei Jacinta Ndunge Munyao Peris Kamau Robert Wahiti Gituru Guang-Wan Hu Qing-Feng Wang | 2020 | Plant Diversity2020，42，6： | 2 |
| 5 | Quantitative determination of pyrethrins by rapid high performance liquid chromatographic analysis显示文摘 | KAMAU S M | 1990 | Pyrethrum Post1990，18，： | 1 |
| 6 | Effects of Genotype, Environment and Management on Yields and Quality of Black Tea显示文摘 | P Okinda Owuor David M Kamau Samson M Kamunya | 2011 | Agriculture Reviews2011，，： | 1 |
| 7 | Isocratic liquid chromatographic method for the analysis of roxithromycin and structurally related substances in bulk samples显示文摘 | Chepkwony H K Kamau F N Rodriguez E | 2001 | Chromatographia2001，54，： | 1 |
| 8 | Functional significance of bioactive peptides derived from milk proteins显示文摘 | Kamau SM Lu RR Chen W | 2010 | Food Reviews International2010，26，： | 1 |
| 9 | Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic fiald显示文摘 | KAMAU SW HASSA PO STEITZ B | 2006 | Nucleic Aeids Res2006，34，5： | 1 |
| 10 | Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication 显示文摘 | Kamau E Takhampunya R Li T | 2009 | J Gen Virol2009，90，8： | 1 |
| 11 | Analysis of genetic variability in Anopheles arabiensis and Anopheles ganvbiae using microsatellite loci显示文摘 | KAMAU L MUKABANA W R HAWLEY W A | 1999 | Insect Molecular Biology1999，8，： | 1 |
| 12 | Effect of lactoperoxidase-thiocyanate-hydrogen peroxide system and storage temperature on keeping quality of raw camel milk显示文摘 | KAMAU P M N LAMUKA PO WANGOH J | 2010 | African Journal of Food Agriculture Nutrition and Development2010，10，10： | 1 |
| 13 | KI3 propeller polymorphisms in Plasmodium folciparum parasites from sub- Saharan Africa显示文摘 | Kamau E Campino S Amenga-Etego L et ol | 2015 | J Infect Dis2015，211，8： | 1 |
| 14 | Functional significance of bioactive peptides derived from milk proteins显示文摘 | KAMAU S M LU R R CHEN W | 2010 | Food Reviews International2010，26，4： | 1 |
| 15 | SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells显示文摘 | Marcia C. Haigis Raul Mostoslavsky Kevin M. Haigis Kamau Fahie Danos C. Christodoulou Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Margaret Karow Gil Blander Cynthia Wolberger Tomas A. Prolla Richard Weindruch Frederick W. Alt Leonard Guaren | 2006 | Cell2006，，5： | 1 |
| 16 | Effectof diagnosis and treatment of inoperable cervical cancer on quality of life among wollqen receiving radiotherapy at Kenyatta National Hospital显示文摘 | Kamau RK Osoti AO Njuguna EM | 2007 | East Afr Med J2007，84，1： | 1 |
| 17 | Dengue virus infection promotes translocation of high mobility group box 1 protein by epithelial cells显示文摘 | Kamau E Takhampunya R Li T | 2008 | J Infect2008，56，2： | 1 |
| 18 | Multiplex qPCR for detection and absolute quantification of malaria显示文摘 | Kamau E Alemayehu S Feghali KC | 2013 | PLoS One2013，8，71： | 1 |
| 19 | Carbon and nutrient stocks of tea plantations differing in age, genotype and plant population density 显示文摘 | Kamau D M Spiertz J Oenema O | 2008 | Plant and Soil2008，307，12： | 1 |
| 20 | Genetic differentiation of Anopheles gambiae population from East and West Africa: comparison of microsatellite and allozyme loci显示文摘 | Lehmann T Hawley WA Kamau L | 1996 | Heredity1996，77，： | 1 |
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