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| 1 | Bioleaehing of heavy metals from a low grade mining ore using Aspergillus niger 显示文摘 | Mulligan C N KamLi M Gibbs B F | 2004 | J Hazard Mater2004，110，： | 1 |
| 2 | Wireless Power Transfer via Strongly Coupled Magnetic Resonances 显示文摘 | Kurs Andre Aristeidis Kamlis Robert Moffatt | 2007 | Science2007，317，3： | 1 |
| 3 | Metagenomics - an advanced approach for noncultivable micro-organisms显示文摘 | Zeyaullah M D Kamli M R Islam B | 2009 | Biotechnology and Molecular Biology Reviews2009，4，： | 1 |
| 4 | Wireless Power Transfer Via Strongly Coupled Magnetic Resonances 显示文摘 | Andre Kurs Aristeidis Kamlis Robert Moffatt | 2007 | Science2007，317，5834： | 1 |
| 5 | Effect of porcine placenta steroid extract on myogenic satellite cell proliferation, transdifferentiation, and lipid accumulation显示文摘 | Eun Lee Majid Kamli Abdul Bhat Smritee Pokharel Dong-Mok Lee Sang Kim Tae Kim SeongKoo Hong Inho Choi | 2012 | In Vitro Cellular & Developmental Biology - Animal2012，，5： | 1 |
| 6 | Dietary flavonoid quercetin and associated health benefitsan overview显示文摘 | JAN A T KAMLI M R MURTAZA I | 2010 | Food Reviews International2010，26，3： | 1 |
| 7 | Metagenomics-an advanced approach for noncultivable micro-organisms 显示文摘 | Zeyaullahl M Kamli MR Islam B | 2009 | Biotechnol Mol Biol Rev2009，4，3： | 1 |
| 8 | Electromagnetically Induced Transparency in Planar Optical Waveguide显示文摘 | Mariam Mohammad Nasser Tohari Ali Ahmad Mohammad Kamli | 2011 | 材料科学与工程(中英文B版)2011，1，6： | 0 |
| 9 | Computational high-throughput screening and in vitro approaches identify CB-006-3;A novel PI3K-BRAF^(V600E) dual targeted inhibitor against melanoma显示文摘Malignant melanoma is characterized by both genetic and molecular alterations that activate phosphoinositide 3-kinase(PI3K),and RAS/BRAF pathways.In this work,through diversity-based high-throughput virtual screening we identified a lead molecule that selectively targets PI3K and BRAF^(V600E) kinases.Computational screening,Molecular dynamics simulation and MMPBSA calculations were performed.PI3K and BRAF^(V600E) kinase inhibition was done.A375 and G-361 cells were used for in vitro cellular analysis to determine antiproliferative effects,annexin V binding,nuclear fragmentation and cell cycle analysis.Computational screening of small molecules indicates compound CB-006-3 selectively targets PI3KCG(gamma subunit),PI3KCD(delta subunit)and BRAF^(V600E).Molecular dynamics simulation and MMPBSA bases binding free energy calculations predict a stable binding of CB-006-3 to the active sites of PI3K and BRAF^(V600E).The compound effectively inhibited PI3KCG,PI3KCD and BRAF^(V600E)kinases with respective IC50 values of 75.80,160.10 and 70.84 nM.CB-006-3 controlled the proliferation of A375 and G-361 cells with GI50 values of 223.3 and 143.6 nM,respectively.A dose dependent increase in apoptotic cell population and sub G0/G1 phase of cell cycle were also observed with the compound treatment in addition to observed nuclear fragmentation in these cells.Furthermore,CB-006-3 inhibited BRAF^(V600E),PI3KCD and PI3KCG in both melanoma cells.Collectively,based on the computational modeling and in vitro validations,we propose CB-006-3 as a lead candidate for selectively targeting PI3K and mutant BRAF^(V600E) to inhibit melanoma cell proliferation.Further experimental validations,including pharmacokinetic evaluations in mouse models will identify the druggability of the proposed lead candidate for further development as a therapeutic agent for treating melanoma. | FAISAL HASSAN TOBEIGEI REEM MGAHTANI AHMAD SHAIKH AMER AL ALI NADER KAMELI HOSSAM KAMLI PRASANNA RAJAGOPALAN | 2021 | Oncology Research2021，29，5： | 0 |
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