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| 1 | Impact and clinical usefulness of genetic data in the surgical management of colorectal cancer liver metastasis: a narrative review显示文摘Importance:In patients who undergo surgery for colorectal cancer liver metastases(CRLM),a number of somatic mutations have been associated with worse overall(OS)and recurrence-free survival(RFS).Although useful,an association with prognosis does not necessarily equate to an impact on surgical management.Objective:The aim of this review was to investigate whether the best-studied somatic mutations impact surgical management of CRLM by informing:(I)post-hepatectomy surveillance;(II)selection of surgical technique;(III)selection of optimal margin width;and(IV)selection of patients for surgery.Lastly,we discuss the refinement of genetic data from overall mutation status to specific variants,as well as lesser studied somatic mutations.Evidence Review:We conducted a computerized search using PubMed and Google Scholar for reports published so far,using mesh headings and keywords related to genetic data and CRLM.Findings:Genetic data may impact surgical management of CRLM in three ways.Firstly,KRAS mutations can predict lung recurrences.Secondly,KRAS mutations may help tailor margin width.Thirdly,KRAS mutations may help tailor surgical technique.Conclusions:Although genetic data may impact post-hepatectomy surveillance,selection of surgical technique and optimal margin width,their use to guide surgical selection remains elusive,as the data cannot support denying surgery to patients according to their somatic mutation profile. | Georgios Antonios Margonis Martin E.Kreis Jaeyun Jane Wang Carsten Kamphues Christopher L.Wolfgang Matthew J.Weiss | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 3 |
| 2 | Ethanol Flame Structure Investigated by Molecular Beam Mass Spectrometry显示文摘 | Kasper T S OBwald P Kamphus M | 2007 | Combustion and Flame2007，150，3： | 1 |
| 3 | The DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study显示文摘 | Carsten Kamphues Nadine Al-Abadi Angelika Dürr Roberta Bova Frederick Klauschen Albrecht Stenzinger Marcus Bahra Hussein Al-Abadi Peter Neuhaus Daniel Seehofer | 2014 | Surgery Today2014，，7： | 1 |
| 4 | Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas显示文摘 | Bahra M Kamphues C Boas-Knoop S | | 0，，05： | 1 |
| 5 | The effect of dietary intake of calcium and phosphorus on the absorption and excretion of phosphorus in chimaera-derived sheep显示文摘 | FIELD A C KAMPHUES J WOOLLIAMS J A | 1983 | Journal Agricultural Science1983，，101： | 1 |
| 6 | Possible interesting dietetic effects of lactulose as a feed additive in pig feed 显示文摘 | Kamphues J Tabeling R Stuke O | 2003 | Deutsche Tierarztliche Wochenschrift2003，110，9： | 1 |
| 7 | Effects of different feeding and housing conditions on dry matter content and consistency of faeces in sows显示文摘 | TABELING R SCHWIER S KAMPHUES J | 2003 | J Anim Physi Anim Nutr2003，87，34： | 1 |
| 8 | Antibiotic growth promoters for the view of animal nutrition显示文摘 | Kamphues J | 1999 | Berliner Und Miinchener Tier rzttiche Wochenschrift1999，112，1011： | 1 |
| 9 | Postoperative Complications Deteriorate Long-Term Outcome in Pancreatic Cancer Patients显示文摘 | Carsten Kamphues Roberta Bova Dorothee Schricke Michael Hippler-Benscheidt Frederick Klauschen Albrecht Stenzinger Daniel Seehofer Matthias Glanemann Peter Neuhaus Marcus Bahra | 2012 | Annals of Surgical Oncology2012，，： | 1 |
| 10 | Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas显示文摘 | Bahra M Kamphues C Boas-Knoop S | 2012 | Pancreas2012，41，2： | 1 |
| 11 | Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer显示文摘 | Kamphues C Wittschieber D Klauschen F | | 0，，01： | 1 |
| 12 | The effect of dietary intake of calcium and phosphorus on the absorption and excretion of phosphorus in chimaera- derived sheep显示文摘 | FIELD A C KAMPHUES J WOOLLIAMS J A | 1983 | J Agr Sci1983，10，3： | 1 |
| 13 | In vitro effects of very low levels of aflatoxin B 1 on free radicals production and bactericidal activity of bovine blood neutrophils显示文摘 | J. Mehrzad G. Klein J. Kamphues P. Wolf N. Grabowski H.J. Schuberth | 2011 | Veterinary Immunology and Immunopathology2011，，1： | 1 |
| 14 | Formationof small PAHs in laminar premixed low-pressure propeneand cyclopentene flames:experiment and modeling显示文摘 | Kamphus M Unkhoff M B Hoinghaus K K | 2008 | Combustion and Flame2008，152，12： | 1 |
| 15 | Viscoelasticity-based magnetic resonance elastography for the assessment of liver fibrosis in hepatitis C patients after liver transplantation 显示文摘 | Kamphues C Klatt D Bova R | 2012 | Rofo2012，184，： | 1 |
| 16 | Ethanol flame structure investigated by molecular beam mass spectrometry 显示文摘 | Kasper T S Oβwald P Kamphus M | 2007 | Combustion and Flame2007，150，3： | 1 |
| 17 | 颗粒饲料的粒度及其对猪生长性能的影响显示文摘在生产中有许多因素会影响饲喂给猪的饲料的形式。一个饲料生产企业必须根据生产饲料的物理形式,非常仔细地考虑怎样生产饲料。 | 任文 赵晓乐 Joseph Kamphues | 2015 | 猪业科学2015，32，7： | 1 |
| 18 | High dietary levels of biotin andzinc to improve health of foot pads in broilers exposed experimentally to litterwith critical moisture content显示文摘 | Abd El-Wahab A Radko D Kamphues J | 2013 | Poulc Sci2013，92，： | 1 |
| 19 | In vitro effects of very low levels of aflatoxin B on free radicals production and bactericidal activity of bovine blood neutrophils显示文摘 | Mehrzad J Klein G Kamphues J | 2011 | Vet Immunol Immunopat hol2011，141，12： | 1 |
| 20 | Prolyl Hydroxylase Domain 2 Protein Is a Strong Prognostic Marker in Human Gastric Cancer显示文摘 | Kamphues Carsten Wittschieber Daniel Klauschen Frederick Kasajima Atsuko Dietel Manfred Schmidt Sven-christian Glanemann Matthias Bahra Marcus Neuhaus Peter Weichert Wilko Stenzinger Albrecht | 2012 | Pathobiology2012，，： | 1 |
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