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| 1 | Understanding p53 functions through p53 antibodies显示文摘TP53 is the most frequently mutated gene across all cancer types. Our understanding of its functions has evolved since its discovery four decades ago. Initially thought to be an oncogene, it was later realized to be a critical tumour suppressor. A significant amount of our knowledge about p53 functions have come from the use of antibodies against its various forms. The early anti-p53 antibodies contributed to the recognition of p53 accumulation as a common feature of cancer cells and to our understanding of p53 DNA-binding and transcription activities. They led to the concept that conformational changes can facilitate p53’s activity as a growth inhibitory protein. The ensuing p53 conformational-specific antibodies further underlined p53’s conformational flexibility, collectively forming the basis for current efforts to generate therapeutic molecules capable of altering the conformation of mutant p53. A subsequent barrage of antibodies against post-translational modifications on p53 has clarified p53’s roles further, especially with respect to the mechanistic details and context-dependence of its activity. More recently, the generation of p53 mutation-specific antibodies have highlighted the possibility to go beyond the general framework of our comprehension of mutant p53-and promises to provide insights into the specific properties of individual p53 mutants. This review summarizes our current knowledge of p53 functions derived through the major classes of anti-p53 antibodies, which could be a paradigm for understanding other molecular events in health and disease. | Kanaga Sabapathy David P.Lane | 2019 | Journal of Molecular Cell Biology2019，11，4： | 15 |
| 2 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 3 |
| 3 | Sustainable Disaster Risk Reduction through Effective Risk Communication Media in Parangtritis Tourism Area,Yogyakarta显示文摘 | I Made Susmayadi Sudibyakto Hidehiko Kanagae Wignyo Adiyoso Emi Dwi Suryanti | 2014 | Procedia Environmental Sciences2014，20，： | 1 |
| 4 | Oxy5, a novel protein from Arabidopsis thaliana , protects mammalian cells from oxidative stress显示文摘 | Anil Kush Kanaga Sabapathy | 2001 | International Journal of Biochemistry and Cell Biology2001，，6： | 1 |
| 5 | JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms显示文摘 | Jean-Pierre D Kanaga S Oskar H | 2002 | J Cell Sci2002，115，22： | 1 |
| 6 | Developments and applications of the self-organizing map and related algorithms显示文摘 | KOHONEN T | 1996 | Mathematics and Computers in Simulation1996，41，： | 1 |
| 7 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 1 |
| 8 | Dialysis efficacy and nutritional status in elderly hemodialyzed patients显示文摘 | Hiroshige K Kabashima N Kanagae K | 1997 | Geriatr Nephrol Urol1997，6，3： | 1 |
| 9 | JNK1 modulates osteoclastogenesis through both c-Jun phosphorylationdependent and -independent mechanisms显示文摘 | Jean-Pierre D Kanaga S Oskar H | 2002 | J Cell Sci2002，115，： | 1 |
| 10 | Plant genotypic diversity and environmental stress interact to negatively affect arthropod community diversity显示文摘 | Kanaga MK Latta IVLC Mock KE Ryel RJ Lindroth RL Pfrender ME | | 0，，04： | 1 |
| 11 | Dialysis efficacy and nutritional status in elderly hemodialyzed patients 显示文摘 | Hiroshige K Kabashima N Kanagae K | 1997 | Geriatr Nephrol Urol1997，6，3： | 1 |
| 12 | Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity显示文摘TAp73,the homologue of the tumour suppressor p53,has dual roles in tumourigenesis:both as a tumour suppressor and as a promoter of tumour growth.We have recently shown that hypoxia,a condition prevalent in tumours,results in the stabilisation of TAp73 through a mechanism involving HIF-1α-mediated repression of the E3 ligase Siah1.Elevated TAp73 in turn regulates the angiogenic transcriptional programme,exemplified by vegf-A activation,thereby promoting angiogenesis and tumour growth.To further understand hypoxia-mediated TAp73 regulation,we have focused on the Adenosine monophosphate(AMP)-dependent protein kinase(AMPK)signalling pathway induced by hypoxia.We show that hypoxia-mediated AMPK activation is required for efficient TAp73 stabilisation,through multiple means by using AMPK-deficient cells or inhibiting its activity and expression.Conversely,direct AMPK activation using its activator AICAR is also sufficient to induce TAp73 stabilisation but this is independent of putative AMPK phosphorylation sites on TAp73,HIF-1αactivation,and transcriptional repression of Siah1.Furthermore,while vegf-A up-regulation upon hypoxia requires AMPK,direct activation of AMPK by AICAR does not activate vegf-A.Consistently,supernatant from cells exposed to hypoxia,but not AICAR,was able to induce tube formation in HUVECs.These data therefore highlight that the processes of TAp73 stabilisation and transcriptional activation of angiogenic target genes by AMPK activation can be decoupled.Collectively,these results suggest that the context of AMPK activation determines the effect on TAp73,and proposes a model in which hypoxia-induced TAp73 stabilisation occurs by parallel pathways converging to mediate its transactivation potential. | Dan Li Iqbal Dulloo Kanaga Sabapathy | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 13 | Corrigendum to‘Understanding p53 functions through p53 antibodies’显示文摘In this article, we have inadvertently omitted the support from the funding agency, which should be as follows. | Kanaga Sabapathy David PLane | 2019 | Journal of Molecular Cell Biology2019，11，12： | 0 |
| 14 | Correction to:context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity显示文摘 | Dan Li Iqbal Dulloo Kanaga Sabapathy | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
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