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| 1 | Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage显示文摘Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high morbidities and mortalities.Aneurysm rupture causes arterial bleeding-induced mechanical brain tissue injuries and elevated intracranial pressure,followed by global cerebral ischemia.Post-subarachnoid hemorrhage ischemia,tissue injuries as well as extravasated blood components and the breakdown products activate microglia,astrocytes and Toll-like receptor 4,and disrupt blood-brain barrier associated with the induction of many inflammatory and other cascades.Once blood-brain barrier is disrupted,brain tissues are directly exposed to harmful blood contents and immune cells,which aggravate brain injuries furthermore.Blood-brain barrier disruption after subarachnoid hemorrhage may be developed by a variety of mechanisms including endothelial cell apoptosis and disruption of tight junction proteins.Many molecules and pathways have been reported to disrupt the blood-brain barrier after subarachnoid hemorrhage,but the exact mechanisms remain unclear.Multiple independent and/or interconnected signaling pathways may be involved in blood-brain barrier disruption after subarachnoid hemorrhage.This review provides recent understandings of the mechanisms and the potential therapeutic targets of blood-brain barrier disruption after subarachnoid hemorrhage. | Hideki Kanamaru Hidenori Suzuki | 2019 | Neural Regeneration Research2019，14，7： | 15 |
| 2 | Assessment of in vitro lymphokine activated killer (LAK) cell activity against renal cancer cell lines and its suppression by serum factor using crystal violet assay显示文摘 | H. Kanamaru O. Yoshida | 1989 | Urological Research1989，，4： | 2 |
| 3 | Hepatic portal venous gas after endoscopy in a patient with anastomotic obstruction显示文摘A 72-year-old male underwent a laparoscopic low anterior resection for advanced rectal cancer.A diverting loop ileostomy was constructed due to an anastomotic leak five days postoperatively.Nine months later,colonoscopy performed through the stoma showed complete anastomotic obstruction.The mucosa of the proximal sigmoid colon was atrophic and whitish.Ten days after the colonoscopy,the patient presented in shock with abdominal pain.Abdominal computed tomography scan showed hepatic portal venous gas(HPVG) and a dilated left colon.HPVG induced by obstructive colitis was diagnosed and a transverse colostomy performed emergently.His subsequent hospital course was unremarkable.Rectal anastomosis with diverting ileostomy is often performed in patients with low rectal cancers.In patients with anastomotic obstruction or severe stenosis,colonoscopy through diverting stoma should be avoided.Emergent operation to decompress the obstructed proximal colon is necessary in patients with a blind intestinal loop accompanied by HPVG. | Ai Sadatomo Koji Koinuma Rihito Kanamaru Yasuyuki Miyakura Hisanaga Horie Alan T Lefor Yoshikazu Yasuda | 2015 | World Journal of Gastrointestinal Surgery2015，7，2： | 2 |
| 4 | Effects of tirilazad mesylate on vasospasm and phospholipid hydroperoxides in a primate model of subarachnoid hemorrhage 显示文摘 | Suzuki H Kanamaru K Kuroki M | 1999 | Stroke1999，30，2： | 1 |
| 5 | The pharmacokinetics of the β2-adrenoceptor agonist, tulobuterol, given transdermally and by inhalation显示文摘 | T. Uematsu M. Nakano K. Kosuge M. Kanamaru M. Nakashima | 1993 | European Journal of Clinical Pharmacology1993，，4： | 1 |
| 6 | A novel member of the Csp A family of genes that is induced by cold shock in Escherichia coli显示文摘 | Nakashima K Kanamaru K Mizuno T | 1996 | J Bacteriol1996，178，10： | 1 |
| 7 | Smad7 is induced by norepinephrine and protects rat hepatocytes from activin A-induced growth inhibition显示文摘 | Kanamaru C Yasuda H Takeda M | 2001 | J Biol Chem2001，276，45： | 1 |
| 8 | Analysis of the sensible heat flux from the exterior surface of buildings using time sequential thermography 显示文摘 | Hoyano A Asano K Kanamaru T | 1999 | Atmospheric Environment1999，33，24： | 1 |
| 9 | Heine oxygenase -1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats显示文摘 | Suzuki H Kanamaru K Tsunoda H | 1999 | J Clin Invest1999，104，1： | 1 |
| 10 | Array-enhanced coherence resonance and forced dynamics in coupled FitzHugh-Nagumo neurons with noise显示文摘 | SHINOHARA Y KANAMARU T SUZUKI H | 2002 | Phys Rev E2002，65，51： | 1 |
| 11 | Non-invasive measurement of coronary flow reserve in children with Kawasaki diserase显示文摘 | Noto N Karasawa K Kanamaru H | 2002 | Heart2002，87，6： | 1 |
| 12 | Analysis of the sensible heat flux from the exterior surface of buildings using time sequential thermography显示文摘 | Hoyano A Asano K Kanamaru T | 1999 | Atmospheric Environment1999，33，24： | 1 |
| 13 | Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy 显示文摘 | Nagao K Kanamaru T | 1999 | Int J Oncol1999，14，4： | 1 |
| 14 | A novel member of the cspA family of genes that is induced by cold shock in Escherichia coli显示文摘 | Nakashima K Kanamaru K Mizuno T | 1996 | J Bacteriol1996，178，： | 1 |
| 15 | Arterial wall changes in cerebral vasospasm显示文摘 | Findlay JM Weir BK Kanamaru K | 1989 | Neurosurgery1989，25，5： | 1 |
| 16 | Associative Memory Retrieval Induced by Fluctuations in a Pulse Neural Network显示文摘 | Takashi Kanamaru Yoichi Okabe | 2000 | Physical Review E2000，62，： | 1 |
| 17 | Hydrothermal decomposition of PCDDs/PCDFs in MSWI fly ash 显示文摘 | YAMAGUCHI H SHIBUYA E KANAMARU Y | 1996 | Chemosphere1996，32，： | 1 |
| 18 | Obmrator bernia: the usefulness of ecnaputer tmnography in diagnosis 显示文摘 | Rieko Ijiri Hitoshi Kanamaru Hidetaro Yokoyama MD | 1996 | Surgery1996，119，2： | 1 |
| 19 | Stability and antiphase domain structure of the pyrochlore solid solution in the ZrO2-Gd2O3 system显示文摘 | UEHARA T KOTO K KANAMARU F | 1987 | Solid State Ionics1987，23，： | 1 |
| 20 | Membrane expression of decay - accelerating factor on neutrophilsfrom normal individuals and patients with paroxysmal nocturnal hernoglobinuria 显示文摘 | Okuda K Kanamaru A Ueda E | 1990 | Blood1990，75，5： | 1 |
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