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| 1 | Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats显示文摘AIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental model.METHODS: Male Wistar albino rats were assigned into 4groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administration, stomach tissues were excised for macroscopic examination and biochemical analysis.RESULTS: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric tissue.CONCLUSION: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity. | Mehmet Kanter Halit Demir Cengiz Karakaya Hanefi Ozbek | 2005 | World Journal of Gastroenterology2005，11，42： | 9 |
| 2 | Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats显示文摘AIM: To investigate the effects of Nigella sativa L (NS)and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl4-treated rats.METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl4-only treated), B (CCl4+UD treated), C (CCl4+NS treated) and D (CCl4+UD+NS treated), each containing 14 animals.All groups received CCl4 (0.8 mL/kg of body weight, sc,twice a week for 60 d). Tn addition, B, C and D groups also received daily J.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand,received only 2 mL/kg normal saline solution for 60 d.Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment.RESULTS: The CCl4 treatment for 60 d increased thelipid peroxidation and liver enzymes,and also decreasedthe antioxidant enzyme levels. NS or UD treatment (aloneor combination) for 60 d decreased the elevated lipidperoxidation and liver enzyme levels and also increasedthe reduced antioxidant enzyme levels.The weight ofrats decreased in group A,and increased in groups B, Cand D.CONCLUSION: NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defense system activity in the CCl4-treated rats. | Mehmet Kanter Omer Coskun Mustafa Budancamanak | 2005 | World Journal of Gastroenterology2005，11，42： | 9 |
| 3 | Microscopic colitis:A large retrospective analysis from a health maintenance organization experience显示文摘AIM:To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer.METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age-and sexmatched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group.RESULTS: A total of 547 cases of MC were identif ied,376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P<0.001), irritable bowel syndrome (IBS) (P<0.001), and thyroid diseases (P<0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group.CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study. | Kevin T Kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas | 2009 | World Journal of Gastroenterology2009，15，25： | 5 |
| 4 | An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR显示文摘 | Marcella Martignoni Ruben de Kanter Pietro Grossi Axel Mahnke Grazia Saturno Mario Monshouwer | 2004 | Chemico-Biological Interactions2004，，1： | 2 |
| 5 | 直肠癌全直肠系膜切除的完成情况和质量评估:一项全州范围内的研究显示文摘目的:全直肠系膜切除(TME)与直肠癌术后局部复发率降低及无病生存率提高相关。但TME在美国的应用程度尚不清楚。本研究旨在探讨美国密歇根州医院TME的完成情况和质量分级的情况。方法:本研究是密歇根外科质量合作组织(MSQC)针对医院和外科医生的结直肠癌手术质量评估项目的一项回顾性队列研究。数据源于2007-2016年参与医院(最初14家医院,现在38家)接受直肠癌切除术患者的病历数据。主要观察指标是外科医生记录的TME完成情况和病理医生报告的TME质量分级。采用χ2检验和线性回归分析TME的完成情况和质量分级。 | 孙艳武 KANTERS A E CLEARY R K OBI S H | 2020 | 结直肠肛门外科2020，26，1： | 2 |
| 6 | Serum creatine kinase and lactate dehydrogenase changes following an eighty kilometer race显示文摘 | Mitchell M. Kanter George R. Lesmes Leonard A. Kaminsky Janet Ham-Saeger Noel D. Nequin | 1988 | European Journal of Applied Physiology and Occupational Physiology1988，，： | 2 |
| 7 | A NEW APPROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA显示文摘Since the 1980s,the widespread use of N fertilizer has not only resulted in a strong increase in agricultural productivity but also caused a number of environmental problems,induced by excess reactive N emissions.A range of approaches to improve N management for increased agricultural production together with reduced environmental impacts has been proposed.The 4R principles(right product,right amount,right time and right place)for N fertilizer application have been essential for improving crop productivity and N use efficiency while reducing N losses.For example,site-specific N management(as part of 4R practice)reduced N fertilizer use by 32%and increased yield by 5%in China.However,it has not been enough to overcome the challenge of producing more food with reduced impact on the environment and health.This paper proposes a new framework of food-chainnitrogen-management(FCNM).This involves good N management including the recycling of organic manures,optimized crop and animal production and improved human diets,with the aim of maximizing resource use efficiency and minimizing environmental emissions.FCNM could meet future challenges for food demand,resource sustainability and environmental safety,key issues for green agricultural transformation in China and other countries. | Xuejun LIU Zhenling CUI Tianxiang HAO Lixing YUAN Ying ZHANG Baojing GU Wen XU Hao YING Weifeng ZHANG Tingyu LI Xiaoyuan YAN Keith GOULDING David KANTER Robert HOWARTH Carly STEVENS Jagdish LADHA Qianqian LI Lei LIU Wim DE VRIES Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 2 |
| 8 | Parallel versus sequential updating for belief propagation decoding 显示文摘 | Kfir H Kanter I | 2003 | Physica A2003，330，： | 1 |
| 9 | Removal of ossified ligamentum flavum via a minimally invasive surgical approach显示文摘 | Wang VY Kanter AS Mummaneni PV | 2008 | Neurosurg Focus2008，25，2： | 1 |
| 10 | Mergers that stick显示文摘 | Kanter R M | 2009 | Harvard Business Review2009，，： | 1 |
| 11 | Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM显示文摘 | Zaltzberg H Kanter Y Aviram M | 1999 | Isr Med Assoc J1999，1，4： | 1 |
| 12 | Needlestick and adverse outcomes in office-based allergy practices显示文摘 | Kanter LJ Siegel C | 2003 | Annals of Allergy Asthma and Immunology2003，90，4： | 1 |
| 13 | Transmural distribution of connexins in rodent hearts显示文摘 | YAMADA KA KANTER EM GREEN KG | 2004 | J Cardiovasc Elec- trophysiol2004，15，： | 1 |
| 14 | Quercetin, aflavonoid antioxidant, prewents and protects streptozotocin-inducedoxidative stress and P-cell damage in rat pancreas显示文摘 | COSKUN O KANTER M KORKMAZ A | 2005 | PharmacologicalResearch2005，51，2： | 1 |
| 15 | Management and implications of intraoperative cerebrospinal fluid leak in transnasoseptal transsphenoidal microsurgery显示文摘 | Kaptain GJ Kanter AS Hamilton DK | 2011 | Neu- rosurgery2011，68，： | 1 |
| 16 | Work and family in the United States:A critical review and agenda for research and policy显示文摘 | Kanter R M | | 0，，01： | 1 |
| 17 | Reverse subclavian flap repair of hypoplastic transverse aorta in infancy显示文摘 | Vincent RN Fyfe DA | 2001 | Ann Thorac Surg2001，71，5： | 1 |
| 18 | Nuclear factor kappaB signaling in atherogenesis显示文摘 | Kanters E Kraal G | 2005 | Arterioscler Thromb Vasc Biol2005，25，5： | 1 |
| 19 | Konno aortoventriculoplasty in children and adolescents from prosthetic valves to the Ross operation显示文摘 | EREZ E KANTER KR TAM VK | 2002 | Ann Thorac Surg2002，74，1： | 1 |
| 20 | Change is everyone' s job: managing the extended enterprise in a globally connected world 显示文摘 | Kanter R M | 1999 | Organizational Dynamics1999，28，1： | 1 |
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