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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Etteetiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, doubleblind, placebo-controlled trial 显示文摘 | Ozueelik DN Karaca MA Sivri B | 2005 | Int J Clin Pract2005，59，12： | 1 |
| 3 | Effectiveness of pre - emptive metoclopramide infusion in alleviating pain, discomforl and nausea associated with nasogastric tube insertion: a randomised, double - blind, placebo - controlled trial 显示文摘 | Ozucelik DN Karaca MA Sivri B | 2005 | Int J CLin Pract2005，59，12： | 1 |
| 4 | Effectiveness of pre - emptive metoclopramide infusion in alleviating pain, discom-fort and nausea associated with nasogastric tube insertion: a randomised, double blind, placebo - controlled trial 显示文摘 | Ozucelik DN Karaca MA Sivri B | 2005 | Int J Clin Pract2005，59，12： | 1 |
| 5 | Emergency admissions due to swallowed foreign bodies in Adults显示文摘 | Erbil B Karaca MA Aslaner MA | 2013 | World J Gastroen- terol2013，19，38： | 1 |
| 6 | Effectiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, doubleblind, placebo-controlled trial 显示文摘 | Ozucelik DN Karaca MA Sivri B | 2005 | Int J Clin Pract2005，59，12： | 1 |
| 7 | Transient rcactive papulotranslucent acrokeratoderma in a 50-year-old woman:case report and review of the literature显示文摘 | Adisen E Karaca F Gürer MA | 2008 | Am J Clin Dermatol2008，9，6： | 1 |
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