|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 2 | Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules显示文摘Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid lesions.Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules.However cases with indeterminate cytological findings still remain a matter of debate.In this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules.A review of the English literature was conducted,and data were analyzed and summarized and integrated from the authors' perspective.The main purpose of thyroid FNA is to identify patients with higher risk for malignancy,and to prevent unnecessary surgeries for benign conditions.The Bethesda System for Reporting Thyroid Cytopathology is the most widely used system for the diagnosis of thyroid FNA specimens.This system also contains guidelines for the diagnosis and treatment of indeterminate or suspicious for malignancy cases.In conclusion,patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%. | Evangelos P Misiakos Niki Margari Christos Meristoudis Nickolas Machairas Dimitrios Schizas Konstantinos Petropoulos Aris Spathis Petros Karakitsos Anastasios Machairas | 2016 | World Journal of Clinical Cases2016，4，2： | 12 |
| 3 | Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer显示文摘AIM To investigate the impact of thymidylate synthase(TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer(m CRC) patients treated with chemotherapy. METHODS Clinical data were collected retrospectively from records of consecutive patients with m CRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untranslated region(UTR) and 5'UTR were classified into three groups according to the probability they have for high, medium and low TYMS expression(and similar levels of risk) based on evidence from previous studies. Univariate and multivariate survival analyses were performed.RESULTS The analysis recovered 89 patients with m CRC(46.1% de novo metastatic disease and 53.9% relapsed). Of these, 46 patients(51.7%) had colon cancer and 43(48.3%) rectal cancer as primary. All patients were treated with fluoropyrimidine-based chemotherapy(5FU or capecitabine) as single-agent or in combination with irinotecan or/and oxaliplatin or/and bevacizumab. With a median follow-up time of 14.8 mo(range 0-119.8), 85 patients(95.5%) experienced disease progression, and 63 deaths(70.8%) were recorded. The 3-year and 5-year OS rate was 25.4% and 7.7% while the 3-year progression-free survival rate was 7.1%. Multivariate analysis of TYMS polymorphisms, KRAS and BRAF with clinicopathological parameters indicated that TYMS 3'UTR polymorphisms are associated with risk for disease progression and death(P < 0.05 and P < 0.03 respectively). When compared to tumors without any del allele(genotypes ins/ins and ins/loss of heterozygosity(LOH) linked with high TYMS expression) tumors with del/del genotype(low expression group) and tumors with ins/del or del/LOH(intermediate expression group) have lower risk for disease progression(HR = 0.432, 95%CI: 0.198-0.946, P < 0.04 and HR = 0.513, 95%CI: 0.287-0.919, P < 0.03 respectively) and death(HR = 0.366, 95%CI: 0.162-0.827, P < 0.02 and HR = 0.559, 95%CI: 0.309-1.113, P < 0.06 respectively). Additionally,KRAS mutation was associated independently with the risk of disease progression(HR = 1.600, 95%CI: 1.011-2.531, P < 0.05). The addition of irinotecan in 1st line chemotherapy was associated independently with lower risk for disease progression and death(HR = 0.600, 95%CI: 0.372-0.969, P < 0.04 and HR = 0.352, 95%CI: 0.164-0.757, P < 0.01 respectively).CONCLUSION The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in m CRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas George Peros Stefanos Konstantoudakis Danai Leventakou Ioannis G Panayiotides Petros Karakitsos Anna Koumarianou | 2017 | World Journal of Gastroenterology2017，23，32： | 4 |
| 4 | Increased levels of circulating platelet-derived microparticles in psoriasis:Possible implications for the associated cardiovascular risk显示文摘AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascular disease,and 12 healthy controls were subjected to measurement of baseline platelet CD62 P, CD63 and CD42 b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes(PMC), platelet-neutrophil complexes(PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles(PMPs) using flow cytometry. Both larger-size(0.5-0.9 μm) and smallersize(< 0.5 μm) PMPs were determined. Serum interleukin(IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index(PASI).RESULTS PMP concentrations were significantly higher in psoriasis patients than controls [mean±standard error of mean(SEM): 22±5/μL vs 11±6/μL; P=0.018), for both smaller-size(10±2/μL vs 4±2/μL; P=0.033) and larger-size(12±3/μL vs 6±4/μL; P=0.014) PMPs. Platelet CD62 P, CD63 and CD42 b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls(mean±SEM: 16%±3% vs 23%±6%; P=0.047). Larger-size PMPs were related with IL-12 levels(P<0.001) and smaller-size PMPs with both IL-12 and IL-17 levels(P<0.001). Total PMPs also correlated with IL-12(P<0.001). CD63 expression was positively correlated with both IL-12 and IL-17(P<0.05). Increased PASI score was associated with increased levels of larger-size PMPs(r=0.45; P=0.011) and increased CD63 expression(r=0.47; P<0.01).CONCLUSION PMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients. | Evangelia Papadavid Konstantina Diamanti Aris Spathis Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos Petros Karakitsos John Lekakis Dimitrios Rigopoulos Ignatios Ikonomidis | 2016 | World Journal of Cardiology2016，8，11： | 2 |
| 5 | Real-time ultasound-guided catheterization of the internal jugular vein:aprospective comparison with the landmark technique in critical care patients显示文摘 | Karakitsos D Labropoulos N De Groot E | 2006 | Crit Care2006，10，6： | 1 |
| 6 | International evidence-based recommendations on ultrasound-guided vascular access显示文摘 | Massimo Lamperti Andrew R. Bodenham Mauro Pittiruti Michael Blaivas John G. Augoustides Mahmoud Elbarbary Thierry Pirotte Dimitrios Karakitsos Jack LeDonne Stephanie Doniger Giancarlo Scoppettuolo David Feller-Kopman Wolfram Schummer Roberto Biffi Eric De | 2012 | Intensive Care Medicine2012，，7： | 1 |
| 7 | Potential of radial basis function neural networks in discriminating benign from malignant lesions of the lower urinary tract 显示文摘 | KARAKITSOS P POULIAKIS A KORDALIS G | 2005 | Anal Quant Cytol Histol2005，27，1： | 1 |
| 8 | Real-time ultra- sound-guided catheterization of the internal jugular vein: a prospec- tive comparison with the landmark technique in critical care pa- tients 显示文摘 | Karakitsos D Labropoulos N De Groot E | 2006 | Crit Care2006，10，6： | 1 |
| 9 | Blood perfusion of the free anterolateral thigh perforator flap:its beneficial effect in the reconstruction of infected wounds in the lower extremity显示文摘 | Gravvanis A Tsoutsos D Karakitsos D | | 0，，1： | 1 |
| 10 | Re- lation of proximal aorta stiffness to left ventricular diastolic function in patients with end-stage renal disease显示文摘 | Patrianakos AP Parthenakis FI Karakitsos D | 2007 | J Am Soc Echocardiogr2007，20，3： | 1 |
| 11 | Optic nerve sonography in the diagnostic evaluation of adult brain injury 显示文摘 | Soldatos T Karakitsos D Chatzimichail K | 2008 | Crit Care2008，12，3： | 1 |
| 12 | Predictive factors used to justify hysterectomy after loop conization:increasing age and severity of disease显示文摘 | Kalogirou D Antoniou G Karakitsos P | 1997 | Eur J Gynecol Oncol1997，18，： | 1 |
| 13 | Real-time ultrasound-guided catheterization of the internal jugular vein : a prospective comparison with the landmark technique in critical care patients 显示文摘 | karakitsos D Labropoulos N De Groot E | 2006 | Crit Care2006，10，6： | 1 |
| 14 | Real-time ultrasound-guided cath-eterisation of the internal jugular vein:aprospective comparison with the landmarktechnique in critical care patients显示文摘 | Karakitsos D Labropoulos N De GrootE et a1 | 2006 | CritCare2006，10，6： | 1 |
| 15 | Real-time ultrasound-guided catheterisation of the internal jugular vein:a prospective comparison with the landmark technique in critical care patients显示文摘 | Karakitsos D Labropoulos N De Groot E | 2006 | Critical Care2006，10，： | 1 |
| 16 | Real-time ultrasound-guided cath- eterization of the internal jugular vein: A prospective comparison with the landmark technique in critical care patients显示文摘 | Karakitsos D Labropoulos N De Groot E | 2006 | Crit Care2006，10，： | 1 |
| 17 | Real-time ultrasound-guided catheterisation of the internal jugular vein:a prospective comparison with the landmark technique in critical care patients显示文摘 | Karakitsos D Labropoulos N De Groot E | | 0，，06： | 1 |
| 18 | Hypothermia therapy after traumatic braininjury in children显示文摘 | Karakitsos D Karabinis A | 2008 | N Engl J Med2008，359，11： | 1 |
| 19 | Left ventricular diastolic dys- function in the intensive care unit:trends and perspectives显示文摘 | Eisen LA Davlouros P Karakitsos D | 2012 | Crit Care Rcs Pract2012，，14： | 1 |
| 20 | Prognostic significance of p53 and Ki67 proteins ex-pression ingreek gastric cancer patients显示文摘 | TZANAKIS N E PEROS G’KARAKITSOS P | 2009 | Acta ChirBelg2009，109，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员