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| 1 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 2 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 3 | Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer显示文摘 | Philippe Rougier Hanno Riess Robert Manges Petr Karasek Yves Humblet Carlo Barone Armando Santoro Sylvie Assadourian Laurence Hatteville Philip A. Philip | 2013 | European Journal of Cancer2013，，12： | 4 |
| 4 | Twelve-month follow-up a controlled trial of intradiscal thermal anuloplasty for back pain due to internal disc disruption显示文摘 | Bogduk N | 2000 | Spine2000，25，20： | 1 |
| 5 | Model studies of polychlorinated dibenzo-p-dioxin formation during municipal refuse incineration显示文摘 | Karasek F W Dickson L C | 1987 | Science1987，237，4816： | 1 |
| 6 | Job demands, Job decision latitude and mental strain: Implications for job redesign 显示文摘 | Karasek R A | 1979 | Administrative science quarterly1979，24，： | 1 |
| 7 | Job demands, job decision latitude, and mental strain: implications for job redesign显示文摘 | Karasek R A | 1979 | Admin- istrative Science Quarterly1979，24，2： | 1 |
| 8 | Twelve-month follow-up of a controlled trial of intradiscal thermal anuloplasty for back pain due to internal disc disruption 显示文摘 | Karasek M Bogduk N | 2000 | Spine2000，25，： | 1 |
| 9 | Melatonin and aging 显示文摘 | Karasek M Reiter BJ | 2002 | Neuroendocrinol Lett2002，，： | 1 |
| 10 | Optimum design of Er3+-Yb3+ codoped fibers for large-signal high-pump-power applications显示文摘 | KARASEK M | 1997 | Quantum Electron1997，33，10： | 1 |
| 11 | Job demands,job decision latitude,and mental strain:Implications for job redesign显示文摘 | Karasek RA | 1979 | Adm Sci Q1979，24，： | 1 |
| 12 | Twelve-month follow-up of a controlled trial of intradiscal thermal anuloplasty for back pain due to internal disc disruption显示文摘 | Karasek M Bogduk N | 2000 | Spine(S0362-2436)2000，25，： | 1 |
| 13 | A Broadly Tunable Erbium-Doped Fiber Ring Laser:Experimentation and Modeling显示文摘 | Bellemare A Karasek M Riviere C | 2001 | IEEE J Select Topics Quantum Electron2001，7，： | 1 |
| 14 | Job demands, job decision latitude, and mental strain: Implications for job redesign显示文摘 | Karasek RA | 1979 | Administra- tive Science Quarterly1979，24，2： | 1 |
| 15 | The Job Content Questionnaire (JCQ):an instrument for internationally comparative assessments of psychosocial job characteristics显示文摘 | Karasek R Brisson C Kawakami N | 1998 | J Occup Health Psychol1998，3，4： | 1 |
| 16 | Twelve-month follow-up of a controlled trial of intradiscal thermal anuloplasty for back pain due to internal disc disruption显示文摘 | Karasek M Bogduk N | 2000 | Spine (Phila Pa 1976)2000，25，20： | 1 |
| 17 | Hereditary absence of sebaceous glands in the mouse显示文摘 | Gates AH Karasek M | 1965 | Science1965，148，： | 1 |
| 18 | The job content questionnaire (JCQ) :an instrument for internationally comparative assessments of psychosocial job characteristics显示文摘 | Brisson C | 1998 | Journal of Occupational Health Psychology1998，3，4： | 1 |
| 19 | Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer显示文摘 | van de VELDE H KARASEK P | 2004 | J Clin Oncol2004，22，8： | 1 |
| 20 | Job demands, job decision latitude, and mental strain: implications for job redesign 显示文摘 | KARASEK R A | 1979 | Admin Sci Q1979，24，： | 1 |
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