|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Laser-direct-drive program: Promise, challenge, and path forward显示文摘Along with laser-indirect(X-ray)-drive and magnetic-drive target concepts,laser direct drive is a viable approach to achieving ignition and gain with inertial confinement fusion.In the United States,a national program has been established to demonstrate and understand the physics of laser direct drive.The program utilizes the Omega Laser Facility to conduct implosion and coupling physics at the nominally 30-kJ scale and lasereplasma interaction and coupling physics at the MJ scale at the National Ignition Facility.This article will discuss the motivation and challenges for laser direct drive and the broad-based program presently underway in the United States. | E.M.Campbell V.N.Goncharov T.C.Sangster S.P.Regan P.B.Radha R.Betti J.F.Myatt D.H.Froula M.J.Rosenberg I.V.Igumenshchev W.Seka A.A.Solodov A.V.Maximov J.A.Marozas T.J.B.Collins D.Turnbull F.J.Marshall A.Shvydky J.P.Knauer R.L.McCrory A.B.Sefkow M.Hohenberger P.A.Michel T.Chapman L.Masse C.Goyon S.Ross J.W.Bates M. Karasik J.Oh J.Weaver A.J.Schmitt K.Obenschain S.P.Obenschain S.Reyes B.Van Wonterghem | 2017 | Matter and Radiation at Extremes2017，2，2： | 10 |
| 2 | A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes显示文摘Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration.Genetic pleiotropy occurs when a single genetic element is associated with more than one phenotype.We aimed to identify pleiotropic loci associated with bone mineral density(BMD)and nonbone phenotypes in genome-wide association studies.In the discovery stage,the NHGRI-EBI Catalog was searched for genome-wide significant associations(P value<5 x 108),excluding bone-related phenotypes.SNiPA was used to identify proxies of the significantly associated single nucleotide polymorphisms(SNPs)(r2=1).We then assessed putative genetic associations of this set of SNPs with femoral neck(FN)and lumbar spine(LS)BMD data from the GEFOS Consortium.Pleiotropic variants were claimed at a false discovery rate<1.4x 103 for FN-BMD and<1.5 x 10-3 for LS-BMD.Replication of these genetic markers was performed among more than 400000 UK Biobank participants of European ancestry with available genetic and heel bone ultrasound data.In the discovery stage,72 BMD-related pleiotropic SNPs were identified,and 12 SNPs located in 11 loci on 8 chromosomes were replicated in the UK Biobank.These SNPs were associated,in addition to BMD,with 14 different phenotypes.Most pleiotropic associations were exhibited by rs479844(AP5B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological cancer.In conclusion,12 BMD-related genome-wide significant SNPs showed pleiotropy with nonbone phenotypes.Pleiotropic associations can deepen the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits. | Maria A.Christou Georgios Ntritsos Georgios Markozannes Fotis Koskeridis Spyros N.Nikas David Karasik Douglas P.Kiel Evangelos Evangelou Evangelia E.Ntzani | 2020 | Bone Research2020，8，3： | 2 |
| 3 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial显示文摘 | Jean-Louis Chiasson Robert G Josse Ramon Gomis Markolf Hanefeld Avraham Karasik Markku Laakso | 2002 | The Lancet . 2002 (9323)2002，，9323： | 2 |
| 4 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial显示文摘 | Jean-Louis Chiasson Robert G Josse Ramon Gomis Markolf Hanefeld Avraham Karasik Markku Laakso | 2002 | The Lancet2002，，9323： | 2 |
| 5 | Electrical remodelling of the human atrium: Similar effects in patients with chronic atrial fibrillation and atrial flutter 显示文摘 | FRANZ M R KARASIK P L LI C | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 6 | Electrical remodeling of the human atrium:similar effects in patients with chronic atrial fibrillation and atrial flutter显示文摘 | Franz MR Karasik PL Li C | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 7 | Elevated serum uric acid a facet of hyperinsulinaemia 显示文摘 | M Modan H Halkin A Karasik | 1987 | Diabetologia1987，30，9： | 1 |
| 8 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor Sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone 显示文摘 | Charbonnel B Karasik A Liu J | 2006 | Diabetes Care2006，29，12： | 1 |
| 9 | Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham osteoporosis study显示文摘 | Ferrari SL Karasik D Liu J | 2004 | J Bone Miner Res2004，19，4： | 1 |
| 10 | Bone geometry and skeletal fragility显示文摘 | Bouxsein ML Karasik D | 2006 | Curr Osteoporos Rep2006，4，2： | 1 |
| 11 | Sitagliptin, a DPP-d inhibitor for the treatment of patients with type 2 diabetes : a review of recent clinical trials 显示文摘 | Avraham Karasik Pablo Aschner harvey Katzeff | 2008 | Curr Med Res Opin2008，24，2： | 1 |
| 12 | Insulin-like factor-1 and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central Precocious puberty显示文摘 | Kanety H Karasik A Pariente C | 1996 | Clin Endocrinol(Oxf)1996，45，1： | 1 |
| 13 | Hyperinsulinemia,sex,and risk of atherosclerotic cardiovascular disease显示文摘 | Modan M Or J Karasik A | 1991 | Circulation1991，84，： | 1 |
| 14 | Smes for power utility applications:a review of technical and cost considerations显示文摘 | Karasik V Dixon K Weber C | 1999 | IEEE Transactions on Applied Superconductivity1999，9，2： | 1 |
| 15 | Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study 显示文摘 | Ferrari SL Karasik D Liu J | 2004 | J Bone Miner Res2004，19，： | 1 |
| 16 | SMES for power u-tility application:a review of technical and cost consider-ations显示文摘 | Dixon K Weber c | 1999 | IEEE Transactions on Applied Supercon-ductivity1999，9，2： | 1 |
| 17 | Electrical remodelling of the human atrium:Similar effects in patients with chronic atrial fibrillation and atrial flutter显示文摘 | Franz MR Karasik PL Li C | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 18 | QSR duration and mortality in patients with congestive heart failure 显示文摘 | InlianoS Fisher SG Karasik PE | 2002 | Am Heart J2002，143，6： | 1 |
| 19 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor Sitagliptin added to ongoing mefformin therapy in patients with type 2 diabetes inadequately controlled with mefformin alone 显示文摘 | Charbonnel B Karasik A Liu J | 2006 | Diabetes Care2006，29，12： | 1 |
| 20 | Insulin-like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women显示文摘 | Rosen CJ Hannan MT | 2002 | Calcified Tissue International2002，71，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员