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| 1 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 2 | Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(14 sites), randomized(1:1), open, parallel groups, active controlled trial was done. After inclusion, subjects with acute symptoms of hemorrhoids, who gave their written, informed consent to participate, were centrally randomized to receive, as outpatients, rSK(200000 IU) or 0.25% phenylephrine suppositories, which had different organoleptic characteristics. Treatment was administered by the rectal route, one unit every 6 h during 48 h for rSK, and up to a maximum of 5 d(20 suppositories) for phenylephrine. Evaluations were performed at 3, 5 and 10 d postinclusion. The main end-point was the 5th-day complete clinical response(disappearance of pain and edema, and ≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were evaluated too. RESULTS: 5thday complete response rates were 83/110(75.5%) and 36/110(32.7%) with rSK and phenylephrine suppositories, respectively. This 42.7% difference(95%CI: 30.5-54.2) was highly significant(P < 0.001). The advantage was detected since the early 3rdday evaluation(37.3% vs 6.4% for the rSK and active control groups, respectively; P < 0.001) and was kept even at the late 10thday assessment(83.6% vs 58.2% for rSK and phenylephrine, respectively; P < 0.001). Time for complete response was significantly shorter(P = 0.031; log-rank test) in the rSK group(median: 4.9 d; 95%CI: 4.8-5.0) with respect to the active control(median: 9.8 d; 95%CI: 9.8-10.0). Thrombectomy was necessary in 1/59 and 8/57 patients with baseline thrombosis in the rSK and phenylephrine groups, respectively(P = 0.016). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely used over-the-counter phen-ylephrine preparation for the treatment of acute hemorrhoidal illness, with an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura | 2014 | World Journal of Gastroenterology2014，20，6： | 4 |
| 3 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | An improved feature selection method based on ant colony optimization (ACO) evaluated on face recog- nition system显示文摘 | Hamidrcza R Karem F | 2008 | Applied Mathematics and Computation2008，205，2： | 1 |
| 5 | Seroprevalence of human papillomavirus type 16 infection in the united states显示文摘 | Stone K M Karem K L Sternberg M R | | 0，，10： | 1 |
| 6 | Fixation of segmental subtrochanteric fractures:a biomechanical study显示文摘 | Karemer WJ Hearn TC Powell JN | 1996 | Clin Orthop Relat Res1996，，332： | 1 |
| 7 | The ^87Sr/^86Sr,^13C and ^18O evolution of Phanerozoic seawater显示文摘 | VEIZER J DAVIN A KAREM A | 1999 | Chemical Geology1999，161，13： | 1 |
| 8 | Integrated stratigraphy of the upper Neoproterozoic succession in Yunnan Province of South China: Re-evaluation of global correlation and carbon cycle显示文摘 | Hiroto Kimura Karem Azmy Masumi Yamamuro Jiang Zhi-Wen James V. Cizdziel | 2005 | Precambrian Research2005，，1： | 1 |
| 9 | Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization 显示文摘 | Kuklin N Dahesia M Karem K | 1997 | J Virol1997，71，： | 1 |
| 10 | Phytases production and phytic acid reduction in rapeseed meal by Aspergillus niger during solid state fermentation显示文摘 | El-Batal A L Karem H Abdel | 2001 | Food Research International2001，34，： | 1 |
| 11 | Oxygen isotope evolution of Phanerozoic seawater显示文摘 | Ján Veizer Peter Bruckschen Frank Pawellek Andreas Diener Olaf G Podlaha Giles A.F Carden Torsten Jasper Christoph Korte Harald Strauss Karem Azmy Davin Ala | 1997 | Palaeogeography, Palaeoclimatology, Palaeoecology1997，，1： | 1 |
| 12 | Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization显示文摘 | Kuklin N Daheshia M Karem K | 1997 | J Virol1997，71，4： | 1 |
| 13 | Fixation of Subtrochanteric Segmental fractures: a blomechanical study显示文摘 | Karemer WJ Hearn TC Powell JN | 1996 | Clin Orthop1996，，332： | 1 |
| 14 | DNA vaccines-a modern gimmick or a boon to vaccinology显示文摘 | Manickan E Karem KL Rouse BT | 1997 | Crit Rev Immunol1997，17，2： | 1 |
| 15 | Phytase production and phytic acid reduction in rapeseed meal by Aspergillus niger during solid state fermentation显示文摘 | EL-BATAL A I KAREM H A | 2001 | Food Res Int2001，34，8： | 1 |
| 16 | Strontium isotope stratigraphy: potential resolution and event correlation显示文摘 | Ján Veizer Dieter Buhl Andreas Diener Stefan Ebneth Olaf G Podlaha Peter Bruckschen Torsten Jasper Christoph Korte Michael Schaaf Davin Ala Karem Azmy | 1997 | Palaeogeography Palaeoclimatology Palaeoecology1997，，1： | 1 |
| 17 | Damping in structures: its evaluation and treatment of uncertainty显示文摘 | Gurley K | 1996 | Journal of Wind Engineering and Industrial Aerodynamics1996，，59： | 1 |
| 18 | Characterization of human immunoglobulin(Ig) isotype and IgG subclass response to Bartonella henselae infection显示文摘 | Mcgill SL Regnery RL Karem KL | 1998 | Infect Imrnun1998，66，12： | 1 |
| 19 | Guidelines for Perioperative Care for Pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS ? ) Society Recommendations显示文摘 | Kristoffer Lassen Marielle M. E. Coolsen Karem Slim Francesco Carli José E. Aguilar-Nascimento Markus Sch?fer Rowan W. Parks Kenneth C. H. Fearon Dileep N. Lobo Nicolas Demartines Marco Braga Olle Ljungqvist Cornelis H. C. Dejong | 2013 | World Journal of Surgery2013，，2： | 1 |
| 20 | Commentary:fast track surgery:the need for improved study design显示文摘 | Karem S Henrik K | 2012 | Int J Colorectal Dis2012，14，8： | 1 |
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