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| 1 | Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer:A critical update显示文摘Gastrointestinal toxicities(GIT), including oral mucositis,nausea and vomiting, and diarrhea, are common side effects of chemotherapy and targeted agents in patients with advanced colorectal cancer and pancreatic cancer. Being often underreported, it is still difficult to precisely establish their burden in terms of both patient's quality of life and cancer care costs. Moreover, with the use of more intensive upfront combination regimens, the frequency of these toxicities is rapidly growing with a potential negative effect also on patient's outcome, as a result of dose reductions, delays or even discontinuation of active treatments. Thus, identifying patients at higher risk of developing GIT as well as an optimal management are paramount in order to improve patient's compliance and outcome. After the description of the main treatment-induced GIT, we discuss the current knowledge on the pathophysiology of these side effects and comment the scales commonly used to assess and grade them. We then provide a critical update on GIT incidence based on the results of key randomized trials conducted in patients with metastatic colorectal cancer and advanced pancreatic cancer. | Giuseppe Aprile Karim Rihawi Elisa De Carlo Stephen T Sonis | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 2 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
| 3 | Cardiac insulin -like growth factor - 1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy 显示文摘 | Maryam M Myrielle M Karim T | 2009 | BMC Cardiovasc Disord2009，9，10： | 1 |
| 4 | Molecular characterization of In 50,a class 1 integron encoding the gene for the extended spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa显示文摘 | Naas T Poired L Karim A | 1999 | FEMS Microbiol Letter1999，176，2： | 1 |
| 5 | Elastic wave scattering by cracks and inclusions in plates:In:plane case显示文摘 | KARIM M R AWAL M A KUNDU T | 1992 | International Journal of Solids and Structures1992，29，19： | 1 |
| 6 | Effects of sodium dodecyl sulphate and sonication treatment on physicochemical properties of starch显示文摘 | Chan H T Bhat R Karim A A | 2010 | Food Chemistry2010，120，： | 1 |
| 7 | Production of bioenergy and biochemical from industrial and agricultural wastewater显示文摘 | Angenent L T Karim K Al-Dahhan M H | 2004 | Trends in Biotechnology2004，22，9： | 1 |
| 8 | The influence of ultrasound on the degree of oxidation of hypochlorite–oxidized corn starch显示文摘 | Chong W T Uthumporn U Karim A A | 2013 | LWT–Food Science and Technology2013，50，： | 1 |
| 9 | The significance of the Wnt pathway in the pathology of human cancers 显示文摘 | Karim R Tse G Putti T | 2004 | Pathology2004，36，2： | 1 |
| 10 | Safety and feasibility of antibiotic de escalation in bacteremic pneumonia 显示文摘 | Khasawneh FA Karim A Mahmood T | 2014 | Infect Drug Resist2014，7，： | 1 |
| 11 | A comparison of external and en- doscopic endonasal dacryocystorhinostomy for acquired nasolacrimal duct obstuction显示文摘 | Karim R Ghabfial R Lynch T | 2011 | Clin Ophthalmol2011，5，： | 1 |
| 12 | The significance of the Wnt pathway in the pathology of human cancers 显示文摘 | Karim R Tse G Putti T | 2004 | Pathology2004，36，2： | 1 |
| 13 | Molecular characterization of In50, a clas s1 intergron encoding the gene for the extended-spectrum β-lactamas VEB-1 in Pseudomonas aeruginosa显示文摘 | Naas T Poirel L Karim A | 1999 | FEMS Microbiol Lett1999，176，： | 1 |
| 14 | A comparison of external and endoscopic endonasal dacryocystorhinostomy for acquired nasolacrimal duct obstruction显示文摘 | KARIM R GHABRIAL R LYNCH T | 2011 | Clin Ophthalmol2011，5，： | 1 |
| 15 | LuxS affects biofilm maturation and detachment of the periodonto pathogen- ic bacterium Eikenella corrodens显示文摘 | Karim M M Hisamoto T Matsunaga T | 2013 | J Biosci Bioeng2013，116，3： | 1 |
| 16 | Underdetermined blind separation of nondisjoint sources in the time-frequency domain 显示文摘 | Abdeldjalil A E B Nguyen L T Karim A M etc | 2007 | IEEE Transactions on Signal Processing2007，55，3： | 1 |
| 17 | LuxS affects biofilm maturation and detachment of the periodontopathogenic bacterium Eikenella corrodens显示文摘 | Karim MM Hisamoto T Matsunaga T | 2013 | J Biosci Bioeng2013，116，3： | 1 |
| 18 | Association of HIV clinical disease progression with profiles of early immune activation:results from a cluster analysis approach显示文摘 | Karim R Mack W J Stiller T | | 0，，09： | 1 |
| 19 | A comparison of ex- ternal andendoscopic endonasal dacryocystorhinostomy for acquired nasolacrimal duct obstruction显示文摘 | Karim R Ghabrial R Lynch T et a/ | 2011 | Clin Ophthalmol2011，5，： | 1 |
| 20 | Functional genomics tool: gene silencing in Ixodes scapularis eggs and nymphs by electro- porated dsRNA 显示文摘 | Karim S Troiano E Mather T N | 2010 | BMC Biotechnol2010，10，： | 1 |
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