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| 1 | Association of mitochondrial dysfunction and,lipid metabolism with type 2diabetes mellitus:A review of literature显示文摘BACKGROUND:Diabetes mellitus (DM)is one of the most prevalent chronic diseases,and its prevalence continues to increase globally.The impact of mitochondrial dysfunction and lipid metabolism on diabetes mellitus and insulin resistance (IR)has been implicated in several previous reports;however,the results of studies are confusing despite four decades of study. METHODS/RESULTS:This review has evaluated updated understanding of the role of mitochondrial dysfunction and lipid metabolism on type 2diabetes,and found that mitochondrial dysfunction and lipid metabolism disorder induce the dysregulation of liver and pancreatic beta cells,insulin resistance,and type 2diabetes. CONCLUSION:Mitochondrial dysfunction and lipid metabolism induce metabolic dysregulation and finally increasing the possibility of diabetes. | Karimeh Haghani Pouyan Asadi Gholamreza Taheripak Ali Noori-Zadeh Shahram Darabi Salar Bakhtiyari | 2018 | Frontiers in Biology2018，13，6： | 1 |
| 2 | siRNA therapeutics in the treatment of diseases显示文摘 | Salar Bakhtiyari Karimeh Haghani Gholam Basati Mohammad Hassan Karimfar | 2013 | Therapeutic Delivery2013，，1： | 1 |
| 3 | Prevalence of fragile X syndrome among patients with mental retardation in the west of Iran显示文摘BACKGROUND:Fragile X syndrome (FXS),an X-linked disorder,is the most common cause of inherited mental retardation. This is caused by a trinucleotide CGG repeat expansion (>200)on the fragile Xmental retardation 1gene (FMR1)becoming methylated leading to a deficiency or absence of the FMR1protein.Determining FXS prevalence in the mentally retarded individuals in the west of Iran was the aim of this study. METHODS:200patients with moderate mental retardation who were clinically suspicious to FXS were screened using cytogenetic and molecular methods.Blood samples were collected and cultured in the specific culture media.The G-Banding method was used for karyotyping and DNA sequencing performed for verifying the results of the cytogenetic tests. RESULTS:16patients (8%)were found to have fragile X syndrome.The results showed that there is no significant association between the fragile X syndrome and economic status and place of residence,however,the relationship between fragile X syndrome and mental retardation in the family history is significant. CONCLUSION:The frequency of FXS was similar to other reports in the preselected patients.For diagnosis of FXS, chromosome analysis must be accompanied by molecular studies. | Peyman Hadi Karimeh Haghani Ali Noori-Zadeh Salar Bakhtiyari | 2018 | Frontiers in Biology2018，13，6： | 0 |
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