|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Temperature and mortality in 11 cities of the Eastern United States显示文摘 | Frank CC Karlyn SH Jonathan M | 2002 | American Journal of Epidemiology2002，155，1： | 1 |
| 2 | The debt maturity choice:an empirical investigation显示文摘 | MITCHELL KARLYN | 1993 | Journal of Financial Research1993，16，2： | 1 |
| 3 | Economies of scale and scope at large commercial banks:Evidence from the Fourier Flexible Functional Form显示文摘 | Karlyn Mitchell Nur May Onvural | | 0，，02： | 1 |
| 4 | Modeling the Evolution of C 4 Photosynthesis显示文摘 | Karlyn D. Beer Mónica V. Orellana Nitin S. Baliga | 2013 | Cell2013，，7： | 1 |
| 5 | The Call, Sinking Fund, and Term-To-Maturity Features of Corporate Bonds:A Empirical Investigation显示文摘 | Mitchell Karlyn | 1991 | Journal of Financial and Quantitative Analysis1991，26，2： | 1 |
| 6 | Economies of scale and scope at large commercial banks: evidence from the fourier flexible functional form 显示文摘 | Karlyn Mitchell Nur M Onvural | 1996 | Journal of Money Credit and Banking1996，28，2： | 1 |
| 7 | Economies of Scale and Scope at Large Commercial Banks:Evidence from the Fourier Flexible Functional Form显示文摘 | MITCHELL Karlyn ONVURAL Nur M | 1996 | Journal of Money Credit and Banking1996，28，2： | 1 |
| 8 | The call,sinking fund,and term-to-maturity features of corporate bonds:a empirical investigation显示文摘 | MITCHELL KARLYN | 1991 | Journal of Financial and Quantitative Analysis1991，26，2： | 1 |
| 9 | Temperature and mortality in 11 cities of the eastern United States 显示文摘 | Frank CC Karlyn SH Jonathan M | 2002 | Am J Epidemiol2002，155，1： | 1 |
| 10 | 熊猫“泰山”一岁啦!显示文摘新中国成立以后,大熊猫在中国外交史上扮演了重要角色,有人称之为“熊猫外交”。美国人喜欢大熊猫超乎想象,其实,全世界的人,有谁不爱憨态可掬、性情温和的熊猫呢?去年7月9日,中国政府租借给美国华盛顿国家动物园的一对熊猫“美香”和“添添”的儿子出世了。10月17日,熊猫宝宝出世一百天的时候,美国国家动物园专门举行仪式,同时邀请民众上网为熊猫宝宝命名。当时有超过20万的人上网投票,从几个候选名字中选择了“泰山”,美国掀起了新一轮的大熊猫热。这股熊猫热从不曾冷却下来,直到“泰山”一周岁生日的时候,依然如此。 | Karlyn Barker 小兰 | 2006 | 疯狂英语(阅读版)2006，0，9： | 0 |
| 11 | A nano-enhanced vaccine for metastatic melanoma immunotherapy显示文摘Aim:Despite the huge advancements in cancer therapies and treatments over the past decade,most patients with metastasized melanoma still die from the disease.This poor prognosis largely results from resistance to conventional chemotherapies and other cytotoxic drugs.We have previously identified 6 antigenic peptides derived from melanomas that have proven efficacious for activating CD4+T cells in clinical trials for melanoma.Our aim was to improve pharmacodynamics,pharmacokinetic and toxicological parameters by individually encapsulating each of the 6 melanoma helper peptides within their own immunogenic nanoliposomes.Methods:We modified these liposomes as necessary to account for differences in the peptides’chemical properties,resulting in 3 distinct formulations.To further enhance immunogenicity,we also incorporated KDO2,a TLR4 agonist,into the lipid bilayer of all nanoliposome formulations.We then conducted in vivo imaging studies in mice and ex vivo cell studies from 2 patient samples who both strongly expressed one of the identified peptides.Results:We demonstrate that these liposomes,loaded with the different melanoma helper peptides,can be readily mixed together and simultaneously delivered without toxicity in vivo.These liposomes are capable of being diffused to the secondary lymphoid organs very quickly and for at least 6 days.In addition,we show that these immunogenic liposomes enhance immune responses to specific peptides ex vivo.Conclusion:Lipid-based delivery systems,including nanoliposomes and lipid nanoparticles,have now been validated for pharmacological(small molecules,bioactive lipids)and molecular(mRNA,siRNA)therapeutic approaches.However,the utility of these formulations as cancer vaccines,delivering antigenic peptides,has not yet achieved the same degree of commercial success.Here,we describe the novel and successful development of a nanoliposome-based cancer vaccine for melanoma.These vaccines help to circumvent drug resistance by increasing a patient’s T cell response,making them more susceptible to checkpoint blockade therapy. | Katelyn E.Salotto Walter C.Olson Jr Karlyn E.Pollack Anuradha Illendula Elishama Michel Sydney Henriques Todd Fox Susan Walker Marya Dunlap-Brown Craig L.Slingluff Jr Mark Kester Helena W.Snyde | 2022 | Cancer Drug Resistance2022，5，3： | 0 |
| 12 | 探索新的学习方法显示文摘哈佛大学教育学研究生院的克里斯·迪迪教授(Professor Chris Dede)相信,兴起的技术扩展了我们创造、分享和掌握知识的能力,也引起了教学方法的改变。他目前正致力于'多人虚拟环境体验模拟装置'的开发。学生们使用这种设备可以探索虚拟城市,并通过相互交流来回答科学问题。下文便是我们摘选的对迪迪教授的访谈。 | Karlyn Morissette 霍思德 | 2004 | 英语沙龙(高中)2004，0，1： | 0 |
| 13 | 发展中国家妇女团体在自然资源经营和管理中的作用 | Karlyn Eckman 李蓓 | 1994 | 林业与社会1994，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员