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| 1 | Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases显示文摘BACKGROUND: The well-known functions of bile acids(BAs) are the emulsification and absorption of lipophilic xenobiotics. However, the emerging evidences in the past decade showed that BAs act as signaling molecules that not only autoregulate their own metabolism and enterohepatic recirculation, but also as important regulators of integrative metabolism by activating nuclear and membrane-bound G protein-coupled receptors. The present review was to get insight into the role of maintenance of BA homeostasis and BA signaling pathways in development and management of hepatobiliary and intestinal diseases.DATA SOURCES: Detailed and comprehensive search of PubM ed and Scopus databases was carried out for original and review articles.RESULTS: Disturbances in BA homeostasis contribute to the development of several hepatobiliary and intestinal disorders, such as non-alcoholic fatty liver disease, liver cirrhosis, cholesterol gallstone disease, intestinal diseases and both hepatocellular and colorectal carcinoma.CONCLUSION: Further efforts made in order to advance the understanding of sophisticated BA signaling network may be promising in developing novel therapeutic strategies related not only to hepatobiliary and gastrointestinal but also systemic diseases. | Bojan Stanimirov Karmen Stankov Momir Mikov | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，1： | 11 |
| 2 | In-situ oxygen profiling and lignin modification in guts of wood-feeding termites显示文摘 | Jing Ke Jian-Zhong Sun Hung D. Nguyen Deepak Singh Karmen C. Lee Haluk Beyenal Shu-Lin Chen | 2010 | Insect Science2010，17，3： | 5 |
| 3 | Hydrogen emission by three wood-feeding subterranean termite species (Isoptera Rhinotermitidae): Production and characteristics显示文摘 | Yueqing Cao Jian-Zhong Sun Jose M. Rodriguez Karmen C. Lee | 2010 | Insect Science2010，17，3： | 3 |
| 4 | Displacement analysis of tunnel support in soft rock around a shallow highway tunnel at golovec显示文摘 | KARMEN FIFER BIZJAK PETKOVSEK B | 2004 | Engineering Geology2004，75，1： | 1 |
| 5 | The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders显示文摘 | Vanesa Stepanov Karmen Stankov Momir Mikov | 2013 | Journal of Receptors and Signal Transduction2013，，4： | 1 |
| 6 | Serum glutumic oxaloaxetic transaminase activity in human acute transmural myocardial infarction 显示文摘 | LaDue JS Wrobleski F Karmen A | 1954 | Science1954，120，： | 1 |
| 7 | Separation of Data on the Training and Te Set for Modelling:a Case udy for Modelling of Five Colour Properties of a White Pigment显示文摘 | Karmen R K Zupan J Majcen N | 2003 | Chemometrics and Intelligent Laboratory Syems2003，65，2： | 1 |
| 8 | A Demographic Overview of the Current and Projected Library Workforce and the Impact of Federal Funding 显示文摘 | Carlos Manjarrez Joyce Ray Karmen Bisher | 2010 | Library Trends2010，59，12： | 1 |
| 9 | Multiple target tracking based on symmetric measurement equations显示文摘 | Karmen E W | 1992 | IEEE Transactions on Automatic Control1992，37，3： | 1 |
| 10 | Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism显示文摘 | Neboj?a Pavlovi? Karmen Stankov Momir Mikov | 2012 | Applied Biochemistry and Biotechnology2012，，7： | 1 |
| 11 | Displacement analysis of tunnel support in soft rock around a shallow highway tunnel at Golovec 显示文摘 | Karmen F B Borut P | 2004 | Engineering Geology2004，75，： | 1 |
| 12 | Transaminase activity in human blood 显示文摘 | Karmen A Wroblewski F Ladue JS | 1954 | J Clin Invest1954，34，1： | 1 |
| 13 | Serum glutamic oxaloacetic transaminase activity in human acute myocardial infarction显示文摘 | Ladue JS Wroblewski F Karmen A | 1954 | Science1954，120，： | 1 |
| 14 | Road traffic: A case study of flow and path-dependency in weighted directed networks显示文摘 | Flavio Bono Eugenio Gutiérrez Karmen Poljansek | 2010 | Physica A: Statistical Mechanics and its Applications2010，，22： | 1 |
| 15 | Transaminase activi- ty in human blood显示文摘 | KARMEN A WROBLEWSKI F LADUE J S | 1955 | J Clin Invest1955，34，1： | 1 |
| 16 | Screening internetforum participants for depression symptoms by as-sembling and enhancing multiple NLP methods 显示文摘 | Karmen C Hsiung RC Wetter T | 2015 | Comput Methods Programs Biomed2015，120，1： | 1 |
| 17 | Engagement of TLR and Dectin-1/Syk Signaling Is Required for Activation of Notch Targets in Dendritic Cells显示文摘Pattern-recognition receptors,such as toll-like receptors(TLRs),detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.In addition,TLR signaling also activates expression of Notch target genes that play crucial roles in suppression of TLR-triggered inflammatory responses.However,whether TLR signaling pathways engaged by other classes of pattern-recognition receptors induce expression of Notch target genes remains unclear.Here we demonstrate that zymosan,a stimulus for TLR2 and dectin-1,strongly induces expression of multiple Notch target genes in both human and murine dendritic cells.Mechanistically,induction of Notch targets by zymosan is both TLR2-and Syk-dependent through activation of mitogen-activated protein kinases and the transcription factor c-Fos.Hence,our data reveals a novel mechanism that efficient induction of Notch target genes requires engagement of TLR and dectin-1/Syk signaling pathways. | Yuna Zhao Chanyang Ju Karmen Au Jimmy Zhu Baohong Zhao Yingli Shang Xiaoyu Hu | 2021 | Infectious Microbes & Diseases2021，3，2： | 1 |
| 18 | Displacement analysis of tunnel support in soft rock around a shallow highway tunnel at Golovec显示文摘 | Karmen Fifer Bizjak Borut Petkov?ek | 2004 | Engineering Geology2004，，1： | 1 |
| 19 | Displacement analysis of tunnel sup-port in soft rock around a shallow highway tunnel at golovec显示文摘 | KARMEN F B BORUT P | 2004 | Engineer in Geology2004，，75： | 1 |
| 20 | Oxyphilic carcinoma of the thyroid gland显示文摘 | Karmen S Giovanni R | 2003 | Arch Oncol2003，11，2： | 1 |
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