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| 1 | Fluorescence and Absorption Spectroscopic Properties of Dipyrrometheneboron Difluoride(BODlPY) Derivatives in Liquids,Lipid Membranes,and Proteins显示文摘 | Karolin J Johansson B A Strundberg L | 1994 | J Am Chem Soc1994，116，： | 1 |
| 2 | Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure显示文摘AIM To investigate the changes of hemodynamic and laboratory parameters during the course of acute liver failure following acetaminophen overdose.METHODS Eight pigs underwent a midline laparotomy following jejunal catheter placement for further acetaminophen intoxication and positioning of a portal vein Doppler flow-probe. Acute liver failure was realized by intrajejunal acetaminophen administration in six animals, two animals were sham operated. All animals were invasively monitored and received standardized intensive care support throughout the study. Portal blood flow, hemodynamic and ventilation parameters were continuously recorded. Laboratory parameters were analysed every eight hours. Liver biopsies were sampled every 24 h following intoxication and upon autopsy.RESULTS Acute liver failure (ALF) occurred after 28 ± 5 h resulted in multiple organ failure and death despite maximal support after further 21 ± 1 h (study end). Portal blood flow (baseline 1100 ± 156 m L/min) increased to a maximum flow of 1873 ± 175 m L/min at manifestation of ALF, which was significantly elevated(P < 0.01). Immediately after peaking, portal flow declined rapidly to 283 ± 135 m L/min at study end. Thrombocyte values (baseline 307 × 103/μL± 34 × 103/μL) of intoxicated animals declined slowly to values of 145 × 103/μL± 46 × 103/μL when liver failure occurred. Subsequent appearance of severe thrombocytopenia in liver failure resulted in values of 11 × 103/μL± 3 × 103/μL preceding fatality within few hours which was significant(P > 0.01).CONCLUSION Declining portal blood flow and subsequent severe thrombocytopenia after acetaminophen intoxication precede fatality in a porcine acute liver failure model. | Karolin Thiel Wilfried Klingert Kathrin Klingert Matthias H Morgalla Martin U Schuhmann Pamela Leckie Yalda Sharifi Nathan A Davies Rajiv Jalan Andreas Peter Christian Grasshoff Alfred Konigsrainer Martin Schenk Christian Thiel | 2017 | World Journal of Gastroenterology2017，23，9： | 1 |
| 3 | Effects of reserve pool on the relationship between respiration and photosynthesis显示文摘 | MOLDAU H KAROLIN A | 1977 | Photosynthetica1977，11，： | 1 |
| 4 | Fluores-cence and absorption spectroscopic properties of dipyr-rometheneboron difluoride(BODIPY)derivatives in liq-uids,lipid membranes,and proteins显示文摘 | Karolin J Johansson L B A Strandberg L | 1994 | J Am Chem Soc1994，116，17： | 1 |
| 5 | 查看详情显示文摘 | Karolin J Johansson B A Strandberg L | | 0，，： | 1 |
| 6 | Common etiologi- cal sources of anxiety, depression, and somatic complaints in ad- olescents: a multiple rater twin study 显示文摘 | HELGA A TRINE W KAROLINE BS | 2016 | Abnorm Child Psy- chol2016，44，1： | 1 |
| 7 | Vitamin D 1a-hydroxylase (CYP1a)polymorphism in Graves'disease,Hashimoto's thyroiditis and type 1 diabetes mellitus in European显示文摘 | Karoline Regulla Maria Segnil | 2002 | Journal of Endocrinology2002，146，： | 1 |
| 8 | Fluorescence and Absorption Spectroscopic Properties of Dipyrrometheneboron Difluoride(Bodipy)Derivatives in Liquids,Lipid-Membranes,and Proteins显示文摘 | Karolin J Johansson L B A Strandberg L | | 0，，17： | 1 |
| 9 | Additional stimu- lation of sGC on top of standard treatment with ARB's may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone显示文摘 | MARKUS A INA O KAROLINE V W | 2011 | American Jour- nal of Medicine2011，16，16： | 1 |
| 10 | Solvent mediated interaction in the structure of the nucleosome core particle at L9Uresolution显示文摘 | DAVEY C A DAVID F S KAROLIN L | 2002 | J Mole Bio2002，319，： | 1 |
| 11 | Fluorescence and absorption spectroscopic properties of dipyrrometheneboron difluoride ( BOD- IPY) derivatives in liquids, lipid membranes, and proteins 显示文摘 | Karolin J Johansson L B A Strandberg L | 1994 | J Am Chem Soc1994，116，： | 1 |
| 12 | Effects of reserve pool on the relationship between respiration and photosynthesis显示文摘 | Moldau H Karolin A | 1977 | Photosynthetica1977，11，： | 1 |
| 13 | VitaminD la-hydroxylage (CYPIa) polymorphism in Graves' disease, Hashimoto's thyr0iditis and type 1 diabetes mellitus in European 显示文摘 | Michael A Pani Karoline Regulla Maria Segnil | 2002 | J Endocrinol2002，146，6： | 1 |
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