|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 2 | Thermal wave imaging with phase sensitive modulated thermography显示文摘 | Busse G Wu D Karpen W | 1992 | Applied Physics1992，71，8： | 1 |
| 3 | Gastrointestinal symp- toms in autism specmma disorder: a meta analysis 显示文摘 | McElhanon BO McCracken C Karpen S | 2014 | Pediatrics2014，133，5： | 1 |
| 4 | Tissues pecific regulation of basic fibroblast growth factor Mma levels by diabetes 显示文摘 | Karpen CW Spanheimer RG Randolph AL | 1992 | Diabetes1992，41，2： | 1 |
| 5 | A chromosome RNAissance 显示文摘 | Demburg AF Karpen GH | 2002 | Cell2002，111，2： | 1 |
| 6 | Lessons from A Faraway Land:The Effect of Spatial Distance on Creative Cognition 显示文摘 | Jia L Hirt E R Karpen S C | 2009 | Journal of Experimental Social Psychology2009，45，5： | 1 |
| 7 | Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries显示文摘 | Qureshi AA Karpen CW Qureshi N | 2011 | Lipids Health Dis2011，10，： | 1 |
| 8 | Thermal wave imaging with phase sensitive modulated thermography显示文摘 | BUSSE G WU D KARPEN W | 1992 | Journai of Applied Physics1992，71，8： | 1 |
| 9 | Liver ischemia and ischemia-reperfusion induces and trafficks the multispecific metal transporter AtpTb to bile duct canaliculi: possible preferential transport of iron into bile 显示文摘 | Goss JA Barshes NR Karpen SJ | 2008 | Biol Trace Elem Res2008，122，1： | 1 |
| 10 | Thermal wave imaging with phase sensitive modulated thermography 显示文摘 | Busse C Wu D Karpen W | 1992 | Journal ofApplied Physics1992，71，8： | 1 |
| 11 | A theoretical model for the measurement of fiber orientation with thermal waves显示文摘 | Karpen W Wu D Busse G | 1999 | Res in Nondestr Eval1999，11，： | 1 |
| 12 | A chromosome RNAissance显示文摘 | Dernburg A F Karpen G H | 2002 | Cell2002，111，2： | 1 |
| 13 | The role of inflammation in cholestasis: clinical and basic aspects显示文摘 | Kosters A Karpen SJ | 2010 | Semin Liver Dis2010，30，2： | 1 |
| 14 | On the State of Legislation Studies in Europe显示文摘 | Ulrich Karpen | 2005 | European Journal of Law Reform2005，，7： | 1 |
| 15 | Increasing Prevalence of Nonalcoholic Fatty Liver Disease Among United States Adolescents, 1988-1994 to 2007-2010显示文摘 | Jean A. Welsh Saul Karpen Miriam B. Vos | 2012 | The Journal of Pediatrics2012，，： | 1 |
| 16 | Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement 显示文摘 | Narkewicz MR Dell Olio D Karpen SJ | 2009 | J Pe- diatr2009，155，6： | 1 |
| 17 | Vaccinations for adult solid-organ transplant recipients: current recommendations and protocols 显示文摘 | Duchini A Goss JA Karpen S | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
| 18 | Efficacy of Fat-Soluble Vitamin Supplementation in Infants With Biliary Atresia显示文摘 | Benjamin L. Shneider John C. Magee Jorge A. Bezerra Barbara Haber Saul J. Karpen Trivellore Raghunathan Philip Rosenthal Kathleen Schwarz Frederick J. Suchy Nanda Kerkar Yumirle Turmelle Peter F. Whitington Patricia R. Robuck Ronald J. Sokol | 2012 | PEDIATRICS2012，，3： | 1 |
| 19 | and business practice:A conceptual model of a service-dominant orientation 显示文摘 | Karpen I O Bove L L Lukas LinMng strategic service- dominant logic BA | 2011 | Journal of Service Research2011，，： | 1 |
| 20 | Determiningcentromere identity: Cyclical stories and forkingpaths显示文摘 | Sullivan B A Blower M D Karpen G H | 2001 | Nature Reviews Genetics2001，2，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员