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102篇 您的检索式:作者名="Karsak"
    题名 作者 年代 出处 被引量
1An integrated decision making approach for ERP system selection显示文摘Karsak E E Ozogul C O 2009Expert Systems with Applications2009,36,1:1
2An integrated decision making approach for ERP system selection显示文摘KARSAK E E OZOGUL C O 2009Expert Sys- tems with Applications2009,36,1:1
3Product planning in quality function deployment using a combined analytic network process and goal programming approach 显示文摘KARSAK E Ertugrul SOZER Sevin 2002Computers & Industrial Engineering2002,44,:1
4Fuzzy multiple objective making approach to prioritize design requirements in quality function deployment显示文摘Karsak E E 2004International Journal of Production Research2004,42,18:1
5Cannabinoid receptor type 2 gene is associated with human osteoporosis显示文摘Karsak M Cohen-Solal M Freudenberg J 2005Hum Mol Genet2005,14,22:1
6Attenuation of allergic contact dermatitis through the endocannabinoid system显示文摘Karsak M Gaffal E Date R 2007Science2007,316,:1
7F3/Contactin acts as a functional ligand for notch during oligodendrocyte maturation显示文摘Hu Q Ang BT Karsak M 2003Cell2003,115,2:1
8An options approach to valuing expansion flexibility in flexible manufacturing system investments 显示文摘Ertugrul Karsak Okan Ozogul 2002The Engineering Economist2002,47,2:1
9Product planning in quality function deployment using a combined analytic network process and goal programming approach显示文摘KARSAK E E SOVER S ALPTEKIN S E 2002Computer & Industrial Engineering2002,47,1:1
10Peripheral cannabinoid receptor,CB2,regulates bone mass显示文摘Ofek O Karsak M Leclerc N 2006Proc Natl Acad Sci U S A2006,103,3:1
11Fuzzy Multiple Objective Program-ming Framework to Prioritize Design Require-ments in Quality Function Deployment显示文摘Karsak E E 2004Com-puters Industrial Engineering2004,47,23:1
12A Combined Fuzzy LinearRegression and Fuzzy Multiple Objective Pro-gramming Approach for Setting Target Levels inQuality Function Deployment显示文摘Sener Z Karsak E E 2011Expert Systemswith Applications2011,38,4:1
13Fuzzy multiple objective programming framework to prioritize design requirements in quality function deployment显示文摘KARSAK E E 2004Computers & Industrial Engineering2004,47,23:1
14Product planning in quality function deployment using a combined analytic network process and goal programming approach显示文摘KARSAK E E SOZER S EMRE A S 2003Computers and Industrial Engineering2003,44,1:1
15Product plan-ning in quality function deployment using a combined ana-lytic network process and goal programming approach显示文摘KARSAK E E SOZER S ALPTEKIN S E 2002Computer&Industrial Engineering2002,47,1:1
16Product planning in quality function deployment using a combined analytic network process and goal programming approach 显示文摘Karsak E E Sozer S Alptekin S E 2003Computers and Industrial Engineering2003,44,1:1
17Fuzzy multiple objective decision making approach to prioritize design requirements in quality function deployment 显示文摘Karsak E E 2004International Journal of Production Research2004,42,18:1
18Improved common weight MCDM model for technology selection显示文摘KARSAK E E AHISKA S S 2008International Journal of Produc- tion Research2008,46,24:1
19Fuzzy muhiple objective programming framework to prioritize design requirement in quality function deployment显示文摘E Ertugrul Karsak 2004Computer&industrial Engineering2004,47,:1
20The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies.Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan 2021Bone Research2021,9,4:1
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