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| 1 | 含酒精的肝炎的管理: 当前的概念显示文摘 Alcoholic hepatitis is a devastating form of acute liver injury seen in chronic alcohol abusers with significant morbidity and mortality.It is a multisystem disease that is precipitated by ingesting large quantities of alcohol with genetic and environmental factors playing a role.Prognostic criteria have been developed to predict disease severity and these criteria can serve as indicators to initiate medical therapy.Primary therapy remains abstinence and supportive care,as continued alcohol abuse is the most important risk factor for disease progression.The cornerstone of supportive care remains aggressive nutritional support,and although acute alcoholic hepatitis has been extensively studied,few specific medical therapies have been successful.Corticosteroids remain the most effective medical therapy available in improving short term survival in a select group of patients with alcoholic hepatitis;however,the long-term outcome of drug therapies is still not entirely clear and further clinical investigation is necessary.While liver transplantation for acute alcoholic hepatitis have demonstrated promising results,this practice remains controversial and has not been advocated universally,with most transplant centers requiring a prolonged period of abstinence before considering transplantation.Extracorporeal liver support devices,although still experimental,have been developed as a form of liver support to give additional time for liver regeneration.These have the potential for a significant therapeutic option in the future for this unfortunately dreadful disease. | Hetal A Karsan Samir Parekh | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Transjugular intrahepatic porto 全身的分流在老: 为门高血压的复杂并发症的减轻显示文摘 AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population group.METHODS:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and 2010.Twentyfive patients were referred for TIPS.We deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver disease.Of the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing TIPS.Sixteen of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 mo.Ascites and/or hydrothorax was controlled following technically successful procedures in 12 of 13 patients.Bleeding was controlled following technically successful procedures in 10 out of 11 patients.CONCLUSION:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients. | Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh Uzma Waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell | 2012 | World Journal of Hepatology2012，4，2： | 4 |
| 3 | Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective?显示文摘 | Brennan M.R. Spiegel Laura Targownik Gareth S. Dulai Hetal A. Karsan Ian M. Gralnek | 2003 | Hepatology2003，，2： | 2 |
| 4 | Apoptosis vascular endothelial cells become procoagulant显示文摘 | Bombeli T Karsan A | 1997 | Blood1997，89，： | 1 |
| 5 | Lipoplysaccharide signaling in endothelial cell显示文摘 | Dauphinee SM Karsan A | 2006 | Lab Invest2006，86，1： | 1 |
| 6 | Impact of nasogastric lavage on outcomes in acute GI bleeding显示文摘 | Edward S. Huang Sundip Karsan Fasiha Kanwal Inder Singh Marc Makhani Brennan M. Spiegel | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 7 | Apoptotic vascular endothelial cells become procoagulant显示文摘 | Bombeli T Karsan A Tait JF | 1997 | Blood1997，89，7： | 1 |
| 8 | Recent insights into the role of Notch signaling in tumorigenesis 显示文摘 | Leong K G Karsan A | 2006 | Blood2006，107，6： | 1 |
| 9 | Signaling pathways induced by vascular endothelial growth factor显示文摘 | | 2000 | Int J Mol Med2000，5，5： | 1 |
| 10 | Lipopolysaccharide signaling in endothelial cells 显示文摘 | Dauphinee SM Karsan A | 2006 | Lab Invest2006，86，1： | 1 |
| 11 | Apoptotic vascular endotheli- al cells become procoagulant 显示文摘 | Bombeli T Karsan A Tait JF | 1997 | Blood1997，89，7： | 1 |
| 12 | Lipopolysaccharide signaling in endothelial cells显示文摘 | DAUPHINEE SM KARSAN A | 2006 | Lab Invest2006，86，1： | 1 |
| 13 | Behavior of concrete under compressive loadings显示文摘 | KARSAN I D JIRSA J O | 1969 | Journal of Structure Division1969，95，12： | 1 |
| 14 | Notch and minichromosome maintenance (MCM) proteins: integration of two ancestral pathways in cell cycle control 显示文摘 | Noseda M Karsan A | 2006 | Cell Cycle2006，5，23： | 1 |
| 15 | Signaling pathways induced by vascular endothelial growth factor (review) 显示文摘 | Larrivee B Karsan A | 2000 | Int J Mol Med2000，5，5： | 1 |
| 16 | Signaling pathways induced by vascular endothelial growth factor (review)显示文摘 | Larrivee B Karsan A | | 0，，05： | 1 |
| 17 | Behaviour of concrete under compressive loadings 显示文摘 | Karsan I K Jirsa J O | 1969 | Journal of Structural Division ASCE1969，95，12： | 1 |
| 18 | Apoptotic vascular endothelial cells become procoagulant 显示文摘 | Bombeli T Karsan A Tait JF Harlan JM | 1997 | Blood1997，89，7： | 1 |
| 19 | Behaviour of concrete under compressive loadings 显示文摘 | Karsan I K Jirsa J O | 1969 | Journal of the Structural Division ASCE1969，95，12： | 1 |
| 20 | Lipopolysaccharide signaling in endothelial cells显示文摘 | Dauphinee SM Karsan A | 2006 | Lab Invest2006，86，1： | 1 |
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