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| 1 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 4 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 5 | Reprogramming the cell cycle machinery to treat cardiovascular disease 显示文摘 | Bicknell KA Brooks G | 2008 | Curr Opin Pharmacol2008，8，2： | 1 |
| 6 | Regulation of signal transudation pathway and gene expression by mood stabilizers and antidepressants显示文摘 | Chen G Hasanat KA BebehuK JM | 1999 | Psychosom Med1999，61，5： | 1 |
| 7 | Osteogenic protein-1 prevents renal fibregenesis associatedwitll ureteral obstruction显示文摘 | Hruska KA Guo G Wozniak M | 2000 | Am J Physiol2000，279，5： | 1 |
| 8 | Cutting edge:Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4 + but not CD8 + T cells显示文摘 | Newell KA He G Guo Z | 1999 | J Immunol1999，163，： | 1 |
| 9 | Realease of prostanglandin E2,IL-6 and IL-8 from human oral epithelial culture models after pxposure to compounds of dental materials显示文摘 | Schmalz G Sc hweikl H Hiller KA | 2000 | Eur J OralSci2000，108，5： | 1 |
| 10 | Nutritional support and infection: Does the route matter显示文摘 | Minard G Kudsk KA | 1998 | World J Surg1998，22，2： | 1 |
| 11 | Synthesis and structureactivity relantionships of 6-heterocyclic-substituted purine as inactivation modiflers of cardiac sodiumchannels显示文摘 | Estsp K G Josef Ka | 1995 | J Med Chem1995，38，： | 1 |
| 12 | Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery显示文摘 | Leber KA Bergloff J Pendl G | 1998 | J Neurosurg1998，88，： | 1 |
| 13 | Demethylation of the MCJ gene in stage Ill/IV epithelial ovarian cancer and re- sponse to chemotherapy 显示文摘 | Strathdee G Vass JK Oien KA | 2005 | Gynecol Oncol2005，97，： | 1 |
| 14 | ERCCl-specific irn?munostaining in non-small-cell lung cancer显示文摘 | Olaussen KA Fouret P Kroemer G | 2007 | N Engl J Med2007，357，15： | 1 |
| 15 | Minimally invasive cystectomy approaches in the treatment of bladder cancer显示文摘 | Cheung G Dasgupta P Guru KA | 2012 | Expert Rev Anticancer Ther2012，12，： | 1 |
| 16 | Treatment of malignant biliary obstruction with polyurethane-covered Wallstents 显示文摘 | Hausegger KA Thurnher S Bodendorfer G | 1998 | AJR Am J Roentgenol1998，170，2： | 1 |
| 17 | Glycogen synthase kinase 3β ( GSK3β ) mediates 6-hydroxydopamine-induced neuronal death 显示文摘 | Chen G Bower KA Ma C | 2004 | FASEB J2004，18，10： | 1 |
| 18 | Glycogen synthase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death 显示文摘 | Chen G Bower KA Ma C | 2004 | FASEB J2004，18，10： | 1 |
| 19 | TNF-alpha and myocardial matrix metalloproteinase in heart failure, relationgship to LV remodeling显示文摘 | Bradham WS Moe G Wendt KA | 2002 | Am J Physiol Heart Circ Physiol2002，282，4： | 1 |
| 20 | Can the cardiomyocyte cell cycle be reprogrammed 显示文摘 | Bicknell KA Coxon CH Brooks G | 2007 | Mol Cell Cardiol2007，42，4： | 1 |
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