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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Mechanic electrical and thermal characterization of G-10CR and G-11CR glass-cloth/epoxy laminates between room temperature and 4K显示文摘 | Kasen M B MacDonald G R Beekman DH Jr Schramm | 1986 | Cryogenics1986，26，： | 1 |
| 3 | Construction and validation of a quality of life instrument for young adults显示文摘 | Chen H Cohen P Kasen S | 2004 | Quality of Life Research2004，13，： | 1 |
| 4 | Association between television viewing and sleep problems during adolescence and early adulthood显示文摘 | Johnson JG Cohen P Kasen S | 2004 | Arch Pediatr Adolesc Med2004，158，6： | 1 |
| 5 | Age-related change in personality disorder trait levels between early adolescence and adulthood:a community-based longitudinal investigation显示文摘 | Johnson JG Cohen P Kasen S | 2000 | Acta Psychiatry Scand2000，102，3： | 1 |
| 6 | An epidemiological study of disorders in late childhood and adolescence:age and gender specific prevalence显示文摘 | Cohen P Cohen J Kasen S | 1993 | J Child Psychol Psychiatry1993，34，6： | 1 |
| 7 | Association of maladaptive parental behavior with psychiatric disorder among parents and their offspring显示文摘 | Johnson JG Cohen P Kasen S | 2001 | Arch Gen Psychiatry2001，58，3： | 1 |
| 8 | Association between television and sleep problems during adolescence and early adulthood 显示文摘 | Johnson JG Cohen P Kasen S | 2004 | Arch Pediatr Adolesc Med2004，158，6： | 1 |
| 9 | An epidemiological study of disorders in late childhood and adolescence:age and gender specific prevalence显示文摘 | Cohen P Cohen J Kasen S | 1993 | J Child Psychol Psychiatry1993，34，6： | 1 |
| 10 | Childhood adversities associated with risk for eating disorders or weight problems during adolescence or early adulthood显示文摘 | Johnson JG Cohen P Kasen S | 2002 | Am J Psychiatry2002，159，3： | 1 |
| 11 | Construction and validation of a quality of life instrument for young adults显示文摘 | Chen H Cohen P Kasen S | 2004 | Quality of Life Research2004，13，： | 1 |
| 12 | Construction and Vali- dation of a Quality of Life Instrument for Young Adults 显示文摘 | Chen H Cohen P Kasen S | 2004 | Quality of Life Research2004，，13： | 1 |
| 13 | Extensive television viewing and the development of attention and learning difficulties during adolescence显示文摘 | Johnson J.G Cohen P Kasen S Brook J.S | | 0，，： | 1 |
| 14 | Minor depression during adolescence and mental health outcomes during adulthood显示文摘 | Johnson JG Cohen P Kasen S | 2009 | Br J Psychiatry2009，195，3： | 1 |
| 15 | Age-related change in per- sonality disorders trait levels between early adolescence and adult- hood:A community-based longitudinal investigation显示文摘 | Johnson JG Cohen P Kasen S | 2000 | Acta Psychiatr Scand2000，102，4： | 1 |
| 16 | Analysis of a Minimum Perturbation Algorithm for Nonsymmetric Linear Systems显示文摘 | Simoncini V | 1997 | SIAM J Numer Anal1997，34，1： | 1 |
| 17 | Association between television viewing and sleep problems during adolescence and early adulthood显示文摘 | Cohen P Kasen S | 2004 | Arch Pediatr Adolesc Med2004，158，6： | 1 |
| 18 | Mechanical,electrical,and thermalcharacterization of G-10CR and G-11CR glass-cloth/epoxy Laminates between room temperatureand 4K显示文摘 | Kasen M B MacDonald G R Beekman D H | 1980 | Advances in Cryogenic Engineering1980，26，： | 1 |
| 19 | Current status of interlaminar shear testing of composite materials atcryogenic temperatures显示文摘 | Kasen M B | 1990 | Advances in Cryogenic Engineering1990，36，： | 1 |
| 20 | Extensive television viewing and the development of attention and learning difficulties during adolescence显示文摘 | Cohen P Kasen S | 2007 | Arch Pediatr Adolesc Med2007，161，5： | 1 |
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