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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Dynamic full-field optical coherence tomography:3D live-imaging of retinal organoids显示文摘Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information.We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids.Coloured images with an endogenous contrast linked to organelle motility are generated,with submicrometre spatial resolution and millisecond temporal resolution,creating a way to identify specific cell types in living tissue via their function. | Jules Scholler Kassandra Groux Olivier Goureau Jose-Alain Sahel Mathias Fink Sacha Reichman Claude Boccara Kate Grieve | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 3 | Vitamin D and multiple sclerosis显示文摘 | Alberto Ascherio Kassandra L Munger K Claire Simon | 2010 | Lancet Neurology2010，，6： | 1 |
| 4 | Unexpected events during the intrahospital transport of critically ill patients 显示文摘 | Jonathan P Kassandra L | 2007 | Acad Emerd Med2007，14，6： | 1 |
| 5 | Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors显示文摘 | AlbertoAscherio Kassandra L.Munger | 2007 | Ann Neurol2007，，6： | 1 |
| 6 | Environmental risk factors for multiple sclerosis. Part I: The role of infection显示文摘 | AlbertoAscherio Kassandra L.Munger | 2007 | Ann Neurol2007，，4： | 1 |
| 7 | Unexpected events during the intrahospital transport of cri- tically ill patients显示文摘 | Jonathan P Kassandra L | 2007 | Acad Emerd Med2007，14，6： | 1 |
| 8 | Inpatient Health Care Utilization in the United States Among Chil-dren,Adolescents,and Young Adults With Nephrotie Syndrome 显示文摘 | Debhie SG Kassandra LM Cheryl LT | 2013 | American Journal of Kidney Diseases2013，61，6： | 1 |
| 9 | Munger Epstein-Barr Virus Infection and Multiple Sclerosis:A Review 显示文摘 | Alberto Ascherio Kassandra L | 2011 | Journal of Neuroimmune Pharmacology2011，，03： | 1 |
| 10 | Self-efficacy as a predictor to PFMT ad- herence in a prevention of urinary incontinence clinical trial显示文摘 | Kassandra L Messer Sandra H | 2007 | Health Edu Behavior2007，34，6： | 1 |
| 11 | Blood Pressure Control Among Persons Without and With Chronic Kidney Disease: US Trends and Risk Factors 1999–2006显示文摘 | Laura C. Plantinga Edgar R. Miller Lesley A. Stevens Rajiv Saran Kassandra Messer Nicole Flowers Linda Geiss Neil R. Powe | 2009 | Hypertension2009，，1： | 1 |
| 12 | TAM receptors:two pathways to regulate adult neurogenesis显示文摘Introduction of neurogenesis:Neurogenesis is a process characterized by the production and differentiation of new neurons from neural stem cells(Emsley et al.,2005).This was previously thought to occur in prenatal and early postnatal development only;however,several studies have shown that it occurs continuously in | Kassandra Johnson Rui Ji | 2015 | Neural Regeneration Research2015，10，3： | 0 |
| 13 | Hepatic rupture secondary to HELLP syndrome: outcomes in three cases显示文摘Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver rupture.Prompt identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5] | Salvador Gomez-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina Méndez-Domínguez | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
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